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Evidence for a purifying selection acting on the β-lactamase locus in epidemic clones of methicillin-resistant Staphylococcus aureus.
Milheiriço C, Portelinha A, Krippahl L, de Lencastre H, Oliveira DC. Milheiriço C, et al. BMC Microbiol. 2011 Apr 15;11:76. doi: 10.1186/1471-2180-11-76. BMC Microbiol. 2011. PMID: 21496235 Free PMC article.
The anti-repressor MecR2 promotes the proteolysis of the mecA repressor and enables optimal expression of β-lactam resistance in MRSA.
Arêde P, Milheiriço C, de Lencastre H, Oliveira DC. Arêde P, et al. PLoS Pathog. 2012;8(7):e1002816. doi: 10.1371/journal.ppat.1002816. Epub 2012 Jul 26. PLoS Pathog. 2012. PMID: 22911052 Free PMC article.
Redefining the role of the β-lactamase locus in methicillin-resistant Staphylococcus aureus: β-lactamase regulators disrupt the MecI-mediated strong repression on mecA and optimize the phenotypic expression of resistance in strains with constitutive mecA expression.
Arêde P, Ministro J, Oliveira DC. Arêde P, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3037-45. doi: 10.1128/AAC.02621-12. Epub 2013 Apr 15. Antimicrob Agents Chemother. 2013. PMID: 23587945 Free PMC article.
Oliveira and H. de Lencastre, PLoS One 6:e23287, 2011). Here, we demonstrate that, contrary to what is currently accepted, the bla regulatory system efficiently disrupts the strong MecI-mediated repression on mecA, enabling the optimal expression of resistance. ...
Oliveira and H. de Lencastre, PLoS One 6:e23287, 2011). Here, we demonstrate that, contrary to what is currently accepted, the bla re
Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization among patients and healthcare workers in a Portuguese hospital: a pre-intervention study toward the control of MRSA.
Amorim ML, Vasconcelos C, Oliveira DC, Azevedo A, Calado E, Faria NA, Pereira M, Castro AP, Moreira A, Aires E, Cabeda JM, Ramos MH, Amorim JM, de Lencastre H. Amorim ML, et al. Microb Drug Resist. 2009 Mar;15(1):19-26. doi: 10.1089/mdr.2009.0881. Microb Drug Resist. 2009. PMID: 19296773
Analysis of typing methods for epidemiological surveillance of both methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains.
Faria NA, Carrico JA, Oliveira DC, Ramirez M, de Lencastre H. Faria NA, et al. J Clin Microbiol. 2008 Jan;46(1):136-44. doi: 10.1128/JCM.01684-07. Epub 2007 Nov 7. J Clin Microbiol. 2008. PMID: 17989188 Free PMC article.
Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus.
Milheiriço C, Oliveira DC, de Lencastre H. Milheiriço C, et al. Antimicrob Agents Chemother. 2007 Sep;51(9):3374-7. doi: 10.1128/AAC.00275-07. Epub 2007 Jun 18. Antimicrob Agents Chemother. 2007. PMID: 17576837 Free PMC article.
Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'.
Milheiriço C, Oliveira DC, de Lencastre H. Milheiriço C, et al. J Antimicrob Chemother. 2007 Jul;60(1):42-8. doi: 10.1093/jac/dkm112. Epub 2007 Apr 28. J Antimicrob Chemother. 2007. PMID: 17468509
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