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An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.
Olivera A, Rivera J. Olivera A, et al. Adv Exp Med Biol. 2011;716:123-42. doi: 10.1007/978-1-4419-9533-9_8. Adv Exp Med Biol. 2011. PMID: 21713655 Free PMC article. Review.
Even in the absence of an antigen challenge, the differentiation and responsiveness of mast cells can be affected by chronic exposure to elevated S1P from a nonmast cell source, whichmay occur under pathophysiological conditions, potentially leading to the hyper-responsive …
Even in the absence of an antigen challenge, the differentiation and responsiveness of mast cells can be affected by chronic exposure to ele …
IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.
Desai A, Jung MY, Olivera A, Gilfillan AM, Prussin C, Kirshenbaum AS, Beaven MA, Metcalfe DD. Desai A, et al. Among authors: olivera a. J Allergy Clin Immunol. 2016 Jun;137(6):1863-1871.e6. doi: 10.1016/j.jaci.2015.09.059. Epub 2016 Jan 7. J Allergy Clin Immunol. 2016. PMID: 26774658 Free PMC article.
CONCLUSION: IL-6 increases MC proliferation and formation of a more reactive phenotype enabled by suppressing proteolytic cleavage of sIL-6R from IL-6R and downregulation of the SOCS3 autoinhibitory pathway. ...
CONCLUSION: IL-6 increases MC proliferation and formation of a more reactive phenotype enabled by suppressing proteolytic cleavage of …
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.
Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD. Hox V, et al. Among authors: olivera a. J Allergy Clin Immunol. 2016 Jul;138(1):187-199. doi: 10.1016/j.jaci.2015.11.024. Epub 2016 Mar 2. J Allergy Clin Immunol. 2016. PMID: 26948077 Free PMC article.
Human umbilical vein endothelial cells derived from patients with AD-HIES or treated with a STAT3 inhibitor did not signal properly through Src or cause appropriate dissolution of the adherens junctions made up of the proteins vascular endothelial-cadherin and β-catenin. . …
Human umbilical vein endothelial cells derived from patients with AD-HIES or treated with a STAT3 inhibitor did not signal properly t …
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.
Dillahunt SE, Sargent JL, Suzuki R, Proia RL, Gilfillan A, Rivera J, Olivera A. Dillahunt SE, et al. Among authors: olivera a. J Immunol. 2013 Mar 1;190(5):2058-67. doi: 10.4049/jimmunol.1201503. Epub 2013 Jan 28. J Immunol. 2013. PMID: 23359503 Free PMC article.
This finding was consistent with the lack of a full allergic response in SphK2-null mice challenged to undergo passive cutaneous anaphylaxis. ...In contrast, human MC responses were dependent only on SphK1, associating with a more robust expression of this isoform a …
This finding was consistent with the lack of a full allergic response in SphK2-null mice challenged to undergo passive cutaneous anap …
Interrogation of sphingosine-1-phosphate receptor 2 function in vivo reveals a prominent role in the recovery from IgE and IgG-mediated anaphylaxis with minimal effect on its onset.
Olivera A, Dillahunt SE, Rivera J. Olivera A, et al. Immunol Lett. 2013 Feb;150(1-2):89-96. doi: 10.1016/j.imlet.2013.01.005. Epub 2013 Jan 18. Immunol Lett. 2013. PMID: 23337656 Free PMC article.
This latter response correlated with a lack of involvement of S1PR2 in the onset of non-lethal IgE/Ag-mediated systemic and cutaneous anaphylaxis. ...A minor role for S1PR2 in mast cell degranulation was uncovered upon engagement of low affinity receptors for IgG an …
This latter response correlated with a lack of involvement of S1PR2 in the onset of non-lethal IgE/Ag-mediated systemic and cutaneous …
New insights on mast cell activation via the high affinity receptor for IgE.
Rivera J, Fierro NA, Olivera A, Suzuki R. Rivera J, et al. Among authors: olivera a. Adv Immunol. 2008;98:85-120. doi: 10.1016/S0065-2776(08)00403-3. Adv Immunol. 2008. PMID: 18772004 Free PMC article. Review.
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model.
Olivera A. Olivera A. Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):1-11. doi: 10.1016/j.prostaglandins.2008.02.005. Epub 2008 Mar 4. Prostaglandins Other Lipid Mediat. 2008. PMID: 18403224 Free PMC article. Review.
Sphingosine-1-phosphate (S1P) is a lipid mediator involved in diverse biological processes, from vascular and neural development to the regulation of lymphocyte trafficking. ...The mast cell, a major effector cell during an allergic response, has proven instrumental …
Sphingosine-1-phosphate (S1P) is a lipid mediator involved in diverse biological processes, from vascular and neural development to t …
A current understanding of Fc epsilon RI-dependent mast cell activation.
Rivera J, Olivera A. Rivera J, et al. Among authors: olivera a. Curr Allergy Asthma Rep. 2008 Mar;8(1):14-20. doi: 10.1007/s11882-008-0004-z. Curr Allergy Asthma Rep. 2008. PMID: 18377769 Review.
Mast cell activation via the high-affinity immunoglobulin (Ig) E receptor Fc epsilon RI is a topic of extensive investigation with therapeutic potential in allergic disease. ...Fyn and Lyn counter-regulate phosphatidylinositol 3-OH kinase (PI3K), controlling the produced a …
Mast cell activation via the high-affinity immunoglobulin (Ig) E receptor Fc epsilon RI is a topic of extensive investigation with th …
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Olivera A, Urtz N, Mizugishi K, Yamashita Y, Gilfillan AM, Furumoto Y, Gu H, Proia RL, Baumruker T, Rivera J. Olivera A, et al. J Biol Chem. 2006 Feb 3;281(5):2515-25. doi: 10.1074/jbc.M508931200. Epub 2005 Nov 29. J Biol Chem. 2006. PMID: 16316995
Engagement of the high affinity receptor for IgE (FcepsilonRI) on mast cells results in the production and secretion of sphingosine 1-phosphate (S1P), a lipid metabolite present in the lungs of allergen-challenged asthmatics. ...Normal activation of SphK1 and -2 was restor …
Engagement of the high affinity receptor for IgE (FcepsilonRI) on mast cells results in the production and secretion of sphingosine 1-phosph …
Essential role for sphingosine kinases in neural and vascular development.
Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL. Mizugishi K, et al. Among authors: olivera a. Mol Cell Biol. 2005 Dec;25(24):11113-21. doi: 10.1128/MCB.25.24.11113-11121.2005. Mol Cell Biol. 2005. PMID: 16314531 Free PMC article.
Sphingosine kinase-null mice exhibited a deficiency of S1P which severely disturbed neurogenesis, including neural tube closure, and angiogenesis and caused embryonic lethality. A dramatic increase in apoptosis and a decrease in mitosis were seen in the devel …
Sphingosine kinase-null mice exhibited a deficiency of S1P which severely disturbed neurogenesis, including neural tube closure, and …
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