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Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers.
Guerin C, Olivi A, Weingart JD, Lawson HC, Brem H. Guerin C, et al. Invest New Drugs. 2004 Jan;22(1):27-37. doi: 10.1023/b:drug.0000006172.65135.3e. Invest New Drugs. 2004. PMID: 14707492 Review.
This agent, Gliadel, delivers the chemotherapeutic drug carmustine (BCNU) from a biodegradable polymer placed in the resection cavity after brain tumor surgery. ...In this review, we will briefly summarize the development of Gliadel from a laboratory idea to its cur …
This agent, Gliadel, delivers the chemotherapeutic drug carmustine (BCNU) from a biodegradable polymer placed in the resection cavity …
Solitary, isolated metastasis from Ewing's sarcoma to the brain: case report.
Olivi A, Donehower RC, Mann RB, Brem H. Olivi A, et al. Surg Neurol. 1991 Mar;35(3):239-43. doi: 10.1016/0090-3019(91)90078-n. Surg Neurol. 1991. PMID: 1996454
We report a case of a 30-year-old woman who developed an intraparenchymal cerebral metastasis from a Ewing's sarcoma of the chest wall diagnosed and treated 3 years earlier and in apparent remission at the time of the neurological presentation (seizures). The …
We report a case of a 30-year-old woman who developed an intraparenchymal cerebral metastasis from a Ewing's sarcoma of …
Intraventricular rupture of a purulent brain abscess: case report.
Zeidman SM, Geisler FH, Olivi A. Zeidman SM, et al. Neurosurgery. 1995 Jan;36(1):189-93; discussion 193. doi: 10.1227/00006123-199501000-00026. Neurosurgery. 1995. PMID: 7708158 Review.
A case of IVROBA with good quality of survival is presented along with the aggressive five-component therapeutic plan used. The five components are: 1) open craniotomy with debridement of abscess cavity, 2) lavage of the ventricular system, 3) 6 weeks of intravenous antibi
A case of IVROBA with good quality of survival is presented along with the aggressive five-component therapeutic plan used. The five
Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas.
Judy KD, Olivi A, Buahin KG, Domb A, Epstein JI, Colvin OM, Brem H. Judy KD, et al. J Neurosurg. 1995 Mar;82(3):481-6. doi: 10.3171/jns.1995.82.3.0481. J Neurosurg. 1995. PMID: 7861228
Both cell lines were more sensitive to 4HC than to a nitrosourea, BCNU, an agent of established value in the local therapy of gliomas. ...The polymer carrier used in this study was a copolyanhydride of dimer erucic acid and sebacic acid 1:1, which was able to mainta …
Both cell lines were more sensitive to 4HC than to a nitrosourea, BCNU, an agent of established value in the local therapy of gliomas …
Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain.
Brem H, Tamargo RJ, Olivi A, Pinn M, Weingart JD, Wharam M, Epstein JI. Brem H, et al. J Neurosurg. 1994 Feb;80(2):283-90. doi: 10.3171/jns.1994.80.2.0283. J Neurosurg. 1994. PMID: 8283268
Eighteen male cynomolgus monkeys were randomly assigned to one of four groups: a control group; a group with implantation of empty polymer; a group with implantation of BCNU-loaded polymer; and a group with implantation of empty polymer in the right he …
Eighteen male cynomolgus monkeys were randomly assigned to one of four groups: a control group; a group with implantation of e …
Direct delivery of platinum-based antineoplastics to the central nervous system: a toxicity and ultrastructural study.
Olivi A, Gilbert M, Duncan KL, Corden B, Lenartz D, Brem H. Olivi A, et al. Cancer Chemother Pharmacol. 1993;31(6):449-54. doi: 10.1007/BF00685034. Cancer Chemother Pharmacol. 1993. PMID: 8453683
Moreover, central nervous system tissue appeared to be less adversely affected by direct exposure to carboplatin since chronic toxicity was not observed in any of the animals receiving carboplatin until a lethal dose was reached. ...We conclude that platinum drugs can be d …
Moreover, central nervous system tissue appeared to be less adversely affected by direct exposure to carboplatin since chronic toxicity was …
Intratumoral chemotherapy.
Walter KA, Tamargo RJ, Olivi A, Burger PC, Brem H. Walter KA, et al. Neurosurgery. 1995 Dec;37(6):1128-45. Neurosurgery. 1995. PMID: 8584154 Review.
In this review, we summarize the major clinical trials and experimental investigations underlying the development of intratumoral chemotherapy as a treatment for gliomas....
In this review, we summarize the major clinical trials and experimental investigations underlying the development of intratumoral chemothera …
Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat.
Olivi A, Ewend MG, Utsuki T, Tyler B, Domb AJ, Brat DJ, Brem H. Olivi A, et al. Cancer Chemother Pharmacol. 1996;39(1-2):90-6. doi: 10.1007/s002800050542. Cancer Chemother Pharmacol. 1996. PMID: 8995504
Recent advances in polymer technology have made feasible the intracranial implantation of a biodegradable polymer capable of local sustained delivery of chemotherapy for brain neoplasms. ...METHODS: Two biodegradable anhydride polymer systems were tested: a copolyme …
Recent advances in polymer technology have made feasible the intracranial implantation of a biodegradable polymer capable of local su …
Neoplastic meningitis following surgical resection of isolated cerebellar metastasis: a potentially preventable complication.
Norris LK, Grossman SA, Olivi A. Norris LK, et al. J Neurooncol. 1997 May;32(3):215-23. doi: 10.1023/a:1005723801479. J Neurooncol. 1997. PMID: 9049883
To confirm a clinical impression that NM is relatively common in patients who undergo surgical resection of an isolated cerebellar metastasis (ICM), a retrospective study was performed. ...A total of 66 patients were identified fifty-five patients underwent …
To confirm a clinical impression that NM is relatively common in patients who undergo surgical resection of an isolated cerebellar me …
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