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Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans.
Olthof MR, Hollman PC, Buijsman MN, van Amelsvoort JM, Katan MB. Olthof MR, et al. J Nutr. 2003 Jun;133(6):1806-14. doi: 10.1093/jn/133.6.1806. J Nutr. 2003. PMID: 12771321
Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans.
Olthof MR, Hollman PC, Vree TB, Katan MB. Olthof MR, et al. J Nutr. 2000 May;130(5):1200-3. doi: 10.1093/jn/130.5.1200. J Nutr. 2000. PMID: 10801919 Clinical Trial.
Chlorogenic acid and caffeic acid are absorbed in humans.
Olthof MR, Hollman PC, Katan MB. Olthof MR, et al. J Nutr. 2001 Jan;131(1):66-71. doi: 10.1093/jn/131.1.66. J Nutr. 2001. PMID: 11208940
Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans.
Olthof MR, Hollman PC, Zock PL, Katan MB. Olthof MR, et al. Am J Clin Nutr. 2001 Mar;73(3):532-8. doi: 10.1093/ajcn/73.3.532. Am J Clin Nutr. 2001. PMID: 11237928 Clinical Trial.
Red wine is a poor source of bioavailable flavonols in men.
de Vries JH, Hollman PC, van Amersfoort I, Olthof MR, Katan MB. de Vries JH, et al. Among authors: olthof mr. J Nutr. 2001 Mar;131(3):745-8. doi: 10.1093/jn/131.3.745. J Nutr. 2001. PMID: 11238754 Clinical Trial.
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women.
Olthof MR, van Vliet T, Boelsma E, Verhoef P. Olthof MR, et al. J Nutr. 2003 Dec;133(12):4135-8. doi: 10.1093/jn/133.12.4135. J Nutr. 2003. PMID: 14652361 Clinical Trial.
Dietary lipids and vascular function: UK Food Standards Agency workshop report.
Sanderson P, Sattar N, Olthof M, Grimble RF, Calder PC, Griffin BA, de Roos NM, Belch JJ, Muller DP, Vita JA. Sanderson P, et al. Among authors: olthof m. Br J Nutr. 2004 Mar;91(3):491-500. doi: 10.1079/BJN20031034. Br J Nutr. 2004. PMID: 15005836 Review.
Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans.
Verhoef P, Steenge GR, Boelsma E, van Vliet T, Olthof MR, Katan MB. Verhoef P, et al. Among authors: olthof mr. Am J Clin Nutr. 2004 Sep;80(3):674-9. doi: 10.1093/ajcn/80.3.674. Am J Clin Nutr. 2004. PMID: 15321808 Clinical Trial.
Effects of betaine intake on plasma homocysteine concentrations and consequences for health.
Olthof MR, Verhoef P. Olthof MR, et al. Curr Drug Metab. 2005 Feb;6(1):15-22. doi: 10.2174/1389200052997366. Curr Drug Metab. 2005. PMID: 15720203 Review.
Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.
Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB. Olthof MR, et al. PLoS Med. 2005 May;2(5):e135. doi: 10.1371/journal.pmed.0020135. Epub 2005 May 31. PLoS Med. 2005. PMID: 15916468 Free PMC article. Clinical Trial.
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