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Page 1
Cognitive Enhancer Noopept Activates Transcription Factor HIF-1.
Zainullina LF, Ivanova TV, Sadovnikov SV, Vakhitova YV, Seredenin SB. Zainullina LF, et al. Dokl Biochem Biophys. 2020 Sep;494(1):256-260. doi: 10.1134/S1607672920050129. Epub 2020 Oct 20. Dokl Biochem Biophys. 2020. PMID: 33119829
Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics. ...It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways …
Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics. ...I …
Effects of noopept on cognitive functions and pubertal process in rats with diabetes.
Gürbüz P, Düzova H, Yildiz A, Çakan P, Kaya GB, Bağ HGG, Durhan M, Gül CC, Taşlidere AÇ. Gürbüz P, et al. Life Sci. 2019 Sep 15;233:116698. doi: 10.1016/j.lfs.2019.116698. Epub 2019 Jul 26. Life Sci. 2019. PMID: 31356906
The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept. ...KEY FINDINGS: Delayed puberty was normalized by noope …
The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + …
Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats.
Gurbuz P, Duzova H, Taslidere AC, Gul CC. Gurbuz P, et al. Biotech Histochem. 2023 Nov;98(5):314-325. doi: 10.1080/10520295.2023.2187460. Epub 2023 Mar 22. Biotech Histochem. 2023. PMID: 36946173
Endocrine and metabolic changes during the pubertal period complicate management of DM. Noopept is a cognitive enhancer that exhibits antidiabetic properties. We investigated the effect of noopept on the histopathology of the cornea, retina, kidney and pancreas in p …
Endocrine and metabolic changes during the pubertal period complicate management of DM. Noopept is a cognitive enhancer that exhibits …
Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
Ostrovskaya RU, Vakhitova YV, Kuzmina USh, Salimgareeva MKh, Zainullina LF, Gudasheva TA, Vakhitov VA, Seredenin SB. Ostrovskaya RU, et al. J Biomed Sci. 2014 Aug 6;21(1):74. doi: 10.1186/s12929-014-0074-2. J Biomed Sci. 2014. PMID: 25096780 Free PMC article.
BACKGROUND: Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Al …
BACKGROUND: Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enh …
Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation.
Zainullina LF, Ivanova TV, Ostrovskaya RU, Gudasheva TA, Vakhitova YV, Seredenin SB. Zainullina LF, et al. Bull Exp Biol Med. 2019 Feb;166(4):466-468. doi: 10.1007/s10517-019-04373-8. Epub 2019 Feb 20. Bull Exp Biol Med. 2019. PMID: 30788746
Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. ...These data suggest that Noopept does not stimulate cell growth....
Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle pa …
[The original novel nootropic and neuroprotective agent noopept].
Ostrovskaia RU, Gudasheva TA, Voronina TA, Seredenin SB. Ostrovskaia RU, et al. Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. Eksp Klin Farmakol. 2002. PMID: 12596521 Review. Russian.
In particular, the structure of pyracetam was designed using dipeptide nootropes. Experimental investigations of noopept (N-phenylacetyl-L-polyglycine ethyl ester) showed that the new drug exceeds pyracetam both with respect to the effective dose level (1000 times lower fo …
In particular, the structure of pyracetam was designed using dipeptide nootropes. Experimental investigations of noopept (N-phenylace …
Noopept normalizes parameters of the incretin system in rats with experimental diabetes.
Ostrovskaya RU, Zolotov NN, Ozerova IV, Ivanova EA, Kapitsa IG, Taraban KV, Michunskaya AM, Voronina TA, Gudasheva TA, Seredenin SB. Ostrovskaya RU, et al. Bull Exp Biol Med. 2014 Jul;157(3):344-9. doi: 10.1007/s10517-014-2562-5. Bull Exp Biol Med. 2014. PMID: 25065315
Noopept had a normalizing effect on these parameters. This influence of Noopept was not related to the inhibition of a major enzyme metabolizing incretins (dipeptidyl peptidase IV). ...Our results suggest that the increase in incretin activity contributes to the ant …
Noopept had a normalizing effect on these parameters. This influence of Noopept was not related to the inhibition of a major e …
Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.
Antipova TA, Nikolaev SV, Ostrovskaya PU, Gudasheva TA, Seredenin SB. Antipova TA, et al. Bull Exp Biol Med. 2016 May;161(1):58-60. doi: 10.1007/s10517-016-3344-z. Epub 2016 Jun 6. Bull Exp Biol Med. 2016. PMID: 27265136
Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M. Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that h …
Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M. Compar …
Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) - An active pharmaceutical ingredient with nootropic activity.
Araj SK, Szeleszczuk Ł, Gubica T, Zielińska-Pisklak M, Bethanis K, Christoforides E, Dudek MK, Pisklak DM. Araj SK, et al. J Pharm Biomed Anal. 2025 Jan 1;252:116474. doi: 10.1016/j.jpba.2024.116474. Epub 2024 Sep 16. J Pharm Biomed Anal. 2025. PMID: 39298839
N-Phenylacetyl-L-prolylglycine ethyl ester (Noopept, GVS-111, omberacetam) is an orally available active pharmaceutical ingredient (API), with neuroprotective properties and ability to enhance cognitive function. ...In this work, the detailed physicochemical analysi …
N-Phenylacetyl-L-prolylglycine ethyl ester (Noopept, GVS-111, omberacetam) is an orally available active pharmaceutical ingred …
Noopept stimulates the expression of NGF and BDNF in rat hippocampus.
Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB. Ostrovskaya RU, et al. Bull Exp Biol Med. 2008 Sep;146(3):334-7. doi: 10.1007/s10517-008-0297-x. Bull Exp Biol Med. 2008. PMID: 19240853
Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect. ...Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer's disease....
Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect. ...Mor …
89 results