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Proteasome-dependent regulation of p21WAF1/CIP1 expression.
Blagosklonny MV, Wu GS, Omura S, el-Deiry WS. Blagosklonny MV, et al. Biochem Biophys Res Commun. 1996 Oct 14;227(2):564-9. doi: 10.1006/bbrc.1996.1546. Biochem Biophys Res Commun. 1996. PMID: 8878553
Lovastatin and simvastatin are modulators of the proteasome.
Wójcik C, Bury M, Stoklosa T, Giermasz A, Feleszko W, Mlynarczuk I, Pleban E, Basak G, Omura S, Jakóbisiak M. Wójcik C, et al. Int J Biochem Cell Biol. 2000 Sep;32(9):957-65. doi: 10.1016/s1357-2725(00)00044-3. Int J Biochem Cell Biol. 2000. PMID: 11084375
Moreover, neither the cytotoxic effects nor the effects on 20 S proteasome activities are prevented by mevalonate, which by itself inhibits the trypsin-like activity of the proteasome. ...Altogether, our results indicate that the closed ring form of lovastatin induces cyto …
Moreover, neither the cytotoxic effects nor the effects on 20 S proteasome activities are prevented by mevalonate, which by itself in …
Separation of cathepsin A-like enzyme and the proteasome: evidence that lactacystin/beta-lactone is not a specific inhibitor of the proteasome.
Ostrowska H, Wójcik C, Wilk S, Omura S, Kozlowski L, Stoklosa T, Worowski K, Radziwon P. Ostrowska H, et al. Int J Biochem Cell Biol. 2000 Jul;32(7):747-57. doi: 10.1016/s1357-2725(00)00021-2. Int J Biochem Cell Biol. 2000. PMID: 10856705
Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin.
Masdehors P, Omura S, Merle-Béral H, Mentz F, Cosset JM, Dumont J, Magdelénat H, Delic J. Masdehors P, et al. Br J Haematol. 1999 Jun;105(3):752-7. doi: 10.1046/j.1365-2141.1999.01388.x. Br J Haematol. 1999. PMID: 10354141
The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70.
Fisher EA, Zhou M, Mitchell DM, Wu X, Omura S, Wang H, Goldberg AL, Ginsberg HN. Fisher EA, et al. J Biol Chem. 1997 Aug 15;272(33):20427-34. doi: 10.1074/jbc.272.33.20427. J Biol Chem. 1997. PMID: 9252351
Furthermore, targeting of this secretory protein to the proteasome is regulated by the molecular chaperone Hsp70 and the availability of apoB's lipid-ligands....
Furthermore, targeting of this secretory protein to the proteasome is regulated by the molecular chaperone Hsp70 and the availability of apo …
Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway.
Sonoda H, Omi K, Hojo K, Nishida K, Omura S, Sugita K. Sonoda H, et al. Life Sci. 1999;65(4):381-94. doi: 10.1016/s0024-3205(99)00259-3. Life Sci. 1999. PMID: 10421424
Analysis using hypothemycin-resistant mutant of Schizosaccharomyces pombe (S. pombe) was carried out to show that S. pombe rhp6+ (homologue of Saccharomyces cerevisiae RAD6) and mammalian ubiquitin-conjugating enzyme 2 (ubc2) are the targets of hypothemycin or its d …
Analysis using hypothemycin-resistant mutant of Schizosaccharomyces pombe (S. pombe) was carried out to show that S. pombe rhp …
Proteasome inhibitors block development of Plasmodium spp.
Gantt SM, Myung JM, Briones MR, Li WD, Corey EJ, Omura S, Nussenzweig V, Sinnis P. Gantt SM, et al. Antimicrob Agents Chemother. 1998 Oct;42(10):2731-8. doi: 10.1128/AAC.42.10.2731. Antimicrob Agents Chemother. 1998. PMID: 9756786 Free PMC article.
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