On the function and relevance of alternative 3'-UTRs in gene expression regulation.
Wiley Interdiscip Rev RNA. 2022.
PMID: 35029331
No abstract available.
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2 articles found by citation matching
On the function and relevance of alternative 3'-UTRs in gene expression regulation.
Wiley Interdiscip Rev RNA. 2021.
PMID: 33843145
Review.
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On the function and relevance of alternative 3'-UTRs in gene expression regulation.
Wiley Interdiscip Rev RNA. 2021 Sep;12(5):e1653. doi: 10.1002/wrna.1653. Epub 2021 Apr 12.
Wiley Interdiscip Rev RNA. 2021.
PMID: 33843145
Review.
Messanger RNA (mRNA) isoforms with alternative 3'-untranslated regions (3'-UTRs) are produced by alternative polyadenylation (APA), which occurs during transcription in most eukaryotic genes. ...Therapies tackling APA mRNA isoforms …
Messanger RNA (mRNA) isoforms with alternative 3'-untranslated regions (3'-UTRs) are produced by …
On the function and relevance of alternative 3'-UTRs in gene expression regulation.
Wiley Interdiscip Rev RNA. 2022 Jan;13(1):e1706. doi: 10.1002/wrna.1706.
Wiley Interdiscip Rev RNA. 2022.
PMID: 35029331
No abstract available.
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides.
Nat Biotechnol. 2019 Feb;37(2):133-138. doi: 10.1038/s41587-019-0013-6. Epub 2019 Jan 28.
Nat Biotechnol. 2019.
PMID: 30692694
Site-directed RNA editing might provide a safer or more effective alternative to genome editing in certain clinical scenarios. Until now, RNA editing has relied on overexpression of exogenous RNA editing enzymes or of endogenous human ADAR (adenosine deaminase acting on RN …
Site-directed RNA editing might provide a safer or more effective alternative to genome editing in certain clinical scenarios. Until …
3'-UTRs and the Control of Protein Expression in Space and Time.
Adv Exp Med Biol. 2019;1203:133-148. doi: 10.1007/978-3-030-31434-7_5.
Adv Exp Med Biol. 2019.
PMID: 31811633
The noncoding elements of an mRNA influence multiple aspects of its fate. For example, 3'-UTRs serve as physical and sequence-based information hubs that direct the time, place, and level of translation of the protein encoded in cis, but often also have additional r …
The noncoding elements of an mRNA influence multiple aspects of its fate. For example, 3'-UTRs serve as physical and sequence- …
Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma.
Genome Res. 2020 Mar;30(3):347-360. doi: 10.1101/gr.257550.119. Epub 2020 Feb 6.
Genome Res. 2020.
PMID: 32029502
Free PMC article.
Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3'-UTR length, resulting in changes in mRNA stability and localization. ...We report widespread, recurrent, and functionally relevant 3'-UTR alterations ass …
Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3'-UTR length, resulting in changes i …
Transcriptional and posttranscriptional regulations of the HLA-G gene.
J Immunol Res. 2014;2014:734068. doi: 10.1155/2014/734068. Epub 2014 Mar 13.
J Immunol Res. 2014.
PMID: 24741620
Free PMC article.
Review.
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major fun …
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained …
Deciphering the impact of genetic variation on human polyadenylation using APARENT2.
Genome Biol. 2022 Nov 5;23(1):232. doi: 10.1186/s13059-022-02799-4.
Genome Biol. 2022.
PMID: 36335397
Free PMC article.
We demonstrate APARENT2's performance on several variant datasets, including functional reporter data and human 3' aQTLs from GTEx. ...For example, we detect an association between gain-of-function mutations in the 3'-end and autism spectrum dis …
We demonstrate APARENT2's performance on several variant datasets, including functional reporter data and human 3' aQTL …
Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity.
Nat Commun. 2021 Jan 12;12(1):335. doi: 10.1038/s41467-020-20483-8.
Nat Commun. 2021.
PMID: 33436550
Free PMC article.
Previous transcriptomic profiling studies have typically focused on separately analyzing mRNA expression, alternative splicing and alternative polyadenylation differences between cell and tissue types. ...Multi-omics factor analyses revealed differing contrib …
Previous transcriptomic profiling studies have typically focused on separately analyzing mRNA expression, alternative splicing …
Gain of RNA function in pathological cases: Focus on myotonic dystrophy.
Biochimie. 2011 Nov;93(11):2006-12. doi: 10.1016/j.biochi.2011.06.028. Epub 2011 Jul 13.
Biochimie. 2011.
PMID: 21763392
Review.
This inherited neuromuscular disorder is caused by a (CTG)n >50 expansion in the 3' non-coding region of the dystrophia myotonica-protein kinase (DMPK) gene. ...This review will focus on toxic RNA gain-of-function as a pathologic mechanism for DM1 and othe …
This inherited neuromuscular disorder is caused by a (CTG)n >50 expansion in the 3' non-coding region of the dystrophia myotonica- …
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons.
Biochim Biophys Acta Gene Regul Mech. 2017 Jun;1860(6):685-694. doi: 10.1016/j.bbagrm.2017.03.002. Epub 2017 Mar 6.
Biochim Biophys Acta Gene Regul Mech. 2017.
PMID: 28274785
The differential expression of mRNAs containing tandem alternative 3' UTRs, achieved by mechanisms of alternative polyadenylation and post-transcriptional regulation, has been correlated with a variety of cellular states. ...Our results i …
The differential expression of mRNAs containing tandem alternative 3' UTRs, achieved by mechanisms of alterna …
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