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Gut microorganisms act together to exacerbate inflammation in spinal cords.
Miyauchi E, Kim SW, Suda W, Kawasumi M, Onawa S, Taguchi-Atarashi N, Morita H, Taylor TD, Hattori M, Ohno H. Miyauchi E, et al. Among authors: onawa s. Nature. 2020 Sep;585(7823):102-106. doi: 10.1038/s41586-020-2634-9. Epub 2020 Aug 26. Nature. 2020. PMID: 32848245
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H. Furusawa Y, et al. Among authors: onawa s. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13. Nature. 2013. PMID: 24226770
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K. Obata Y, et al. Among authors: onawa s. Nat Immunol. 2014 Jun;15(6):571-9. doi: 10.1038/ni.2886. Epub 2014 Apr 28. Nat Immunol. 2014. PMID: 24777532