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1952 34
1953 38
1954 29
1955 50
1956 44
1957 32
1958 48
1959 27
1960 27
1961 31
1962 40
1963 58
1964 67
1965 56
1966 61
1967 67
1968 73
1969 77
1970 93
1971 97
1972 84
1973 74
1974 123
1975 175
1976 249
1977 237
1978 232
1979 259
1980 249
1981 292
1982 323
1983 358
1984 432
1985 386
1986 494
1987 618
1988 689
1989 933
1990 1053
1991 1104
1992 1323
1993 1405
1994 1553
1995 1590
1996 1733
1997 1799
1998 1845
1999 2035
2000 2290
2001 2291
2002 2541
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2004 3063
2005 3409
2006 3670
2007 3984
2008 4571
2009 4947
2010 5676
2011 6187
2012 6734
2013 7450
2014 8566
2015 9224
2016 9069
2017 9140
2018 10045
2019 10751
2020 12286
2021 13132
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2023 12482
2024 14382
2025 16587
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2027 2

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Misinformation and Overestimation of Computed Tomography Lung Cancer Screening Harms-Methodology Matters: A Joint Statement from The Society of Thoracic Surgeons, the American Society for Radiation Oncology, and the American College of Radiology.
Tupper HI, Shrager JB, Moghanaki D, Simone CB 2nd, Kazerooni EA, Hart EM, Cooke DT, Velotta JB, Tong BC, Keshava HB, Erkmen CP, Yang CJ, Servais EL. Tupper HI, et al. Int J Radiat Oncol Biol Phys. 2027 Nov 11:S0360-3016(25)06618-0. doi: 10.1016/j.ijrobp.2025.12.030. Online ahead of print. Int J Radiat Oncol Biol Phys. 2027. PMID: 41556863 No abstract available.
Misinformation and Overestimation of Computed Tomography Lung Cancer Screening Harms - Methodology Matters: A Joint Statement from the Society of Thoracic Surgeons, the American Society for Radiation Oncology, and the American College of Radiology.
Tupper HI, Shrager JB, Moghanaki D, Simone CB 2nd, Kazerooni EA, Hart EM, Cooke DT, Velotta JB, Tong BC, Keshava HB, Erkmen CP, Yang CJ, Servais EL. Tupper HI, et al. Ann Thorac Surg. 2027 Nov 11:S0003-4975(25)01112-9. doi: 10.1016/j.athoracsur.2025.11.005. Online ahead of print. Ann Thorac Surg. 2027. PMID: 41556861 No abstract available.
Assessment of risk factors of breast cancer among women in Dodoma, Tanzania: a community-based cross-sectional study.
Yahaya JJ, Joho AA. Yahaya JJ, et al. Libyan J Med. 2026 Dec 31;21(1):2625359. doi: 10.1080/19932820.2026.2625359. Epub 2026 Feb 7. Libyan J Med. 2026. PMID: 41653056 Free PMC article.
Assessment of risk factors of breast cancer in the general population provides insightful information towards prevention of breast cancer. ...Therefore, there is an urgency for targeted awareness and screening for breast cancer among younger women in T …
Assessment of risk factors of breast cancer in the general population provides insightful information towards prevention of breast …
Clostridium butyricum alleviates multiple myeloma by remodeling the bone marrow microenvironment and inhibiting PI3K/AKT pathway through the gut‒bone axis.
Wang J, Zi F, Liu W, Liu C, Zhang Z, Kong L, Xu X, Wei J, Chen T, Li J. Wang J, et al. Gut Microbes. 2026 Dec 31;18(1):2609455. doi: 10.1080/19490976.2025.2609455. Epub 2026 Jan 2. Gut Microbes. 2026. PMID: 41481427 Free PMC article.
Emerging evidence reveals a strong connection between the gut microbiota and cancer. However, the exact role of gut microbiota dysbiosis in multiple myeloma (MM) is poorly understood, and the therapeutic potential of microbiota-targeted interventions represents a promising …
Emerging evidence reveals a strong connection between the gut microbiota and cancer. However, the exact role of gut microbiota dysbio …
A machine-learning informed circulating microbial DNA signature for early diagnosis of esophageal adenocarcinoma.
Li Y, Xu C, Park H, Omstead AN, Anees M, Sherry C, Khan AF, Grayhack E, Weksler B, Wagner P, Bartlett DL, Meltzer SJ, Zaidi AH, Goel A. Li Y, et al. Gut Microbes. 2026 Dec 31;18(1):2604334. doi: 10.1080/19490976.2025.2604334. Epub 2025 Dec 24. Gut Microbes. 2026. PMID: 41439274 Free PMC article.
Esophageal adenocarcinoma (EAC) has seen a dramatic rise in incidence in developed countries over the past three decades. Early detection of its precursors-gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and high-grade dysplasia (HGD) is critical f …
Esophageal adenocarcinoma (EAC) has seen a dramatic rise in incidence in developed countries over the past three decades. Early de …
Update of incidence and survival in patients with cervical cancer in the United States from 2000 to 2021.
Wang S, Zhu Q, Lu Y, Yang X, Li Z, Jiang H, Hua K, Fu J. Wang S, et al. J Gynecol Oncol. 2026 Dec 18. doi: 10.3802/jgo.2026.37.e36. Online ahead of print. J Gynecol Oncol. 2026. PMID: 41514315 Free article.
OBJECTIVE: The implementation of human papillomavirus-based screening in the early 2000s and advancements in targeted therapies and immunotherapy have necessitated updated insights into the incidence and survival trends of cervical cancer in the U.S. METHODS: …
OBJECTIVE: The implementation of human papillomavirus-based screening in the early 2000s and advancements in targeted therapie …
Integrating virtual screening and molecular dynamics simulations to identify emodin as a PYCR1 inhibitor modulating docetaxel sensitivity in prostate cancer.
Liu S, Lao Y, Cheng L, Xiao X, Ma L, Wang W, Zhao K, Li W, Zhou Z, Li Q, Tao Y, Liu S, Dong Z. Liu S, et al. J Enzyme Inhib Med Chem. 2026 Dec;41(1):2622725. doi: 10.1080/14756366.2026.2622725. Epub 2026 Feb 10. J Enzyme Inhib Med Chem. 2026. PMID: 41665114
Docetaxel (DTX) resistance is the main cause of treatment failure in castration-resistant prostate cancer (CRPC). Pyrroline-5-carboxylic acid reductase 1 (PYCR1) is an enzyme involved in proline metabolism. It is highly expressed in various cancers and promotes malignant p …
Docetaxel (DTX) resistance is the main cause of treatment failure in castration-resistant prostate cancer (CRPC). Pyrroline-5-carboxy …
Determinants of patient delay and its association with quality of life among young women with breast cancer in China: A cross-sectional study.
Peng Y, Ma J, Liu L, Xiao J, Gu C. Peng Y, et al. Asia Pac J Oncol Nurs. 2026 Jan 6;13:100846. doi: 10.1016/j.apjon.2025.100846. eCollection 2026 Dec. Asia Pac J Oncol Nurs. 2026. PMID: 41658476 Free PMC article.
OBJECTIVE: The incidence of breast cancer in young women (< 40 years old) has been increasing in recent years. Patient delay is significant to disease prognosis, thus early diagnosis and prompt effective therapy represent the key elements in controlling breast …
OBJECTIVE: The incidence of breast cancer in young women (< 40 years old) has been increasing in recent years. Patient delay is si …
Rationale and recommendations for improving early-stage oncology diagnosis, treatment, and access.
Aguiar-Ibáñez R, Goldschmidt D, Zhou ZY, Eales J, Peters S, Cardoso F, Ciani O, Arunachalam A, Haiderali A, Roediger A, Black CM, Martinez E, Garrison LP Jr. Aguiar-Ibáñez R, et al. J Med Econ. 2026 Dec;29(1):345-362. doi: 10.1080/13696998.2026.2623775. Epub 2026 Feb 7. J Med Econ. 2026. PMID: 41653456 Free article. Review.
Despite these benefits, disparities in early-stage detection persist across tumor types due to challenges in screening, public awareness, and the aggressive nature of certain cancers. ...This paper is a call to action for relevant stakeholders to take a coord …
Despite these benefits, disparities in early-stage detection persist across tumor types due to challenges in screening, …
Geographic disparities and health inequality evolution in the disease burden of tracheal, bronchus, and lung cancer in Asia: a 33-year longitudinal analysis and future projections.
Wang H, Qin X, Zhang X, Wang N, Wu Z, Xiao Z. Wang H, et al. Ann Med. 2026 Dec;58(1):2624212. doi: 10.1080/07853890.2026.2624212. Epub 2026 Feb 2. Ann Med. 2026. PMID: 41630487 Free PMC article.
Projections suggested further increases in ASPR (+28.7%) and ASIR (+21.6%) by 2038. CONCLUSION: The TBL cancer burden in Asia is rising, with marked regional, gender, age disparities and deteriorating health equity. ...Targeted strategies, including enhanced early …
Projections suggested further increases in ASPR (+28.7%) and ASIR (+21.6%) by 2038. CONCLUSION: The TBL cancer burden in Asia is risi …
DNA methylation triage of human papillomavirus-positive atypical squamous cells of undetermined significance in cervical cancer screening.
Xia W, Wang J, Yang X, Sha Y, Hou F, Li J, Teng Z, Wang J, Shen F, Jie P. Xia W, et al. J Obstet Gynaecol. 2026 Dec;46(1):2623828. doi: 10.1080/01443615.2026.2623828. Epub 2026 Feb 2. J Obstet Gynaecol. 2026. PMID: 41627315 Free article.
BACKGROUND: Triage of human papillomavirus (HPV)-positive women with atypical squamous cells of undetermined significance (ASC-US) remains a longstanding clinical challenge in cervical cancer screening, as conventional strategies often lead to excessive colposcopy r …
BACKGROUND: Triage of human papillomavirus (HPV)-positive women with atypical squamous cells of undetermined significance (ASC-US) remains a …
Application of artificial intelligence in head and neck squamous cell carcinoma.
Wang P, Tian J, Zheng G, Chen Y, Ren X. Wang P, et al. Ann Med. 2026 Dec;58(1):2620191. doi: 10.1080/07853890.2026.2620191. Epub 2026 Jan 27. Ann Med. 2026. PMID: 41593888 Free PMC article. Review.
The swift progress of artificial intelligence (AI) in medicine has enabled large-scale biomarker screening and the creation of predictive models, which are critical for identifying immunotherapy responders and predicting patient outcomes. ...
The swift progress of artificial intelligence (AI) in medicine has enabled large-scale biomarker screening and the creation of predic …
Frailty profiles and symptomatic radiation pneumonitis in patients with lung cancer undergoing radiotherapy: A latent class analysis.
Zhang J, Zhao X, Li S, Liao J, Xu L, Fei Y, Wu J, Guan Q. Zhang J, et al. Asia Pac J Oncol Nurs. 2025 Dec 23;13:100840. doi: 10.1016/j.apjon.2025.100840. eCollection 2026 Dec. Asia Pac J Oncol Nurs. 2025. PMID: 41585540 Free PMC article.
OBJECTIVE: This study aimed to identify distinct frailty subtypes and their influencing factors, and to further explore the relationship between these frailty characteristics and the occurrence of symptomatic radiation pneumonitis (SRP) in patients with lung cancer undergo …
OBJECTIVE: This study aimed to identify distinct frailty subtypes and their influencing factors, and to further explore the relationship bet …
Toward next-generation therapeutic HPV vaccines: A review on expanding the antigen repertoire and an integrated bioinformatics selection framework.
Zhang D, Guo S, Yuan J, Hu Y, Li K, Han Y. Zhang D, et al. Hum Vaccin Immunother. 2026 Dec;22(1):2610899. doi: 10.1080/21645515.2025.2610899. Epub 2026 Jan 22. Hum Vaccin Immunother. 2026. PMID: 41571571 Free PMC article. Review.
We systematically evaluate established HPV therapeutic antigens and vaccine platforms, and comprehensively explore the frontier of novel antigens, advanced screening technologies, and recent vaccine innovations. Central is a bioinformatics-guided antigen selection framewor …
We systematically evaluate established HPV therapeutic antigens and vaccine platforms, and comprehensively explore the frontier of novel ant …
Human papillomavirus vaccinations' association to childbirth rates.
Koivisto T, Eriksson T, Hokkanen M, Apter D, Lehtinen M, Louvanto K. Koivisto T, et al. Hum Vaccin Immunother. 2026 Dec;22(1):2598691. doi: 10.1080/21645515.2025.2598691. Epub 2026 Jan 21. Hum Vaccin Immunother. 2026. PMID: 41562152 Free PMC article.
Prophylactic HPV vaccines are effective against cervical cancer and its precursors, but data on their impact on fertility and pregnancy are limited. ...Nearly half of the HPV-vaccinated women participated in a cervical screening trial between ages 22 and 28. Childbi …
Prophylactic HPV vaccines are effective against cervical cancer and its precursors, but data on their impact on fertility and pregnan …
The gut microbiota-obesity axis in the pathogenesis and prognosis of breast cancer.
Zhang H, Wang Y, Ning B, Wang Y, Sun T, Xu J. Zhang H, et al. Ann Med. 2026 Dec;58(1):2611203. doi: 10.1080/07853890.2025.2611203. Epub 2026 Jan 7. Ann Med. 2026. PMID: 41503829 Free PMC article.
BACKGROUND: Breast cancer (BC) remains a major global health concern, accounting for 11.7% of all cancer cases and ranking as the second leading cause of female cancer-related deaths worldwide. ...Addressing the gut-breast axis may offer transformative potent …
BACKGROUND: Breast cancer (BC) remains a major global health concern, accounting for 11.7% of all cancer cases and ranking as …
Automated diagnosis of usual interstitial pneumonia on chest CT via the mean curvature of isophotes.
Savadjiev P, Rezanejad M, Bhatnagar S, Camirand D, Kauffmann C, Siddiqi K, Dandurand RJ, Bourgouin P, Chartrand-Lefebvre C, Semionov A. Savadjiev P, et al. Eur J Radiol Open. 2026 Jan 10;16:100723. doi: 10.1016/j.ejro.2025.100723. eCollection 2026 Jun. Eur J Radiol Open. 2026. PMID: 41568076 Free PMC article.
PURPOSE: To test whether the mean curvature of isophotes (MCI), a geometric image transformation, can be used to improve automatic detection on chest CT of Usual Interstitial Pneumonia (UIP), a determining radiological pattern in the diagnosis of Interstitial Lung Diseases …
PURPOSE: To test whether the mean curvature of isophotes (MCI), a geometric image transformation, can be used to improve automatic detect …
A 2D/3D nanoplatform for electrochemical diagnosis of miRNA-122 in breast cancer cell lines.
Esmaeilian A, Arab N, Yazdian F, Hosseini M, Mortazavi SMR, Ganjali MR. Esmaeilian A, et al. Bioelectrochemistry. 2026 Jun;169:109209. doi: 10.1016/j.bioelechem.2025.109209. Epub 2025 Dec 22. Bioelectrochemistry. 2026. PMID: 41455374
A novel, label-free electrochemical biosensor was precise engineered for the ultrasensitive and selective detection of miRNA-122, a pivotal biomarker in breast cancer diagnostics. This innovative sensing platform harnesses the exceptional conductivity of Ti(3)C(2) M …
A novel, label-free electrochemical biosensor was precise engineered for the ultrasensitive and selective detection of miRNA-122, a p …
An electrochemical biosensing platform based on alpha-iron trioxide/ferriferrous oxide magnetic nanocomposites for early diagnosis of hepatocellular carcinoma.
Zhang H, Ouyang H, Zhou Z, Wan T, Li Y, Liu R. Zhang H, et al. Bioelectrochemistry. 2026 Jun;169:109203. doi: 10.1016/j.bioelechem.2025.109203. Epub 2025 Dec 15. Bioelectrochemistry. 2026. PMID: 41406518
The detection of biologically active proteins in complex biological matrices such as serum remains challenging. ...The moderate magnetism of the alphaITFO MNCs enabled efficient magnetic separation, while their compatibility with the magnetic glassy carbon electrode (MGCE) …
The detection of biologically active proteins in complex biological matrices such as serum remains challenging. ...The moderate magne …
Highly sensitive detection of HER2 DNA based on enzyme-free target-triggered biped DNA walker combined with ARGET ATRP.
Zhai X, He X, Li F, Zhang Y, Yang H, Liu Y. Zhai X, et al. Bioelectrochemistry. 2026 Jun;169:109196. doi: 10.1016/j.bioelechem.2025.109196. Epub 2025 Dec 13. Bioelectrochemistry. 2026. PMID: 41401663
Breast cancer (BC) is one of the most common cancers in women and a major global health challenge. Human epidermal growth factor receptor 2 (HER2) an important biomarker of BC, and its early detection is of great significance for the early diagnosis an …
Breast cancer (BC) is one of the most common cancers in women and a major global health challenge. Human epidermal growth factor rece …
Modular PVDF-PEI membrane-based SERS sensor for rapid on-site detection of methamphetamine in complex matrices.
Cai X, Chen Y, Xu L, Tao H, Ye J, Huang B, Huang C, Chen Y, Huang W, Lin D, Lin X, Fan M, Feng S. Cai X, et al. Talanta. 2026 May 15;302:129441. doi: 10.1016/j.talanta.2026.129441. Epub 2026 Jan 20. Talanta. 2026. PMID: 41576579
Methamphetamine (METH), a highly addictive central nervous system stimulant, poses a serious threat to public health, highlighting the urgent need for rapid, sensitive, and reliable on-site detection strategies. Although traditional chromatographic-mass spectrometry techni …
Methamphetamine (METH), a highly addictive central nervous system stimulant, poses a serious threat to public health, highlighting the urgen …
A dual-locked DNA biosensor based on entropy drive circuit/ hybridization chain reaction cascade amplification for AND logic detection of APE1 and miR-21.
Wang X, Li X, Li Z, Shu Y. Wang X, et al. Talanta. 2026 May 15;302:129428. doi: 10.1016/j.talanta.2026.129428. Epub 2026 Jan 18. Talanta. 2026. PMID: 41558405
Accurate identification of cancer cells is crucial for early cancer diagnosis and treatment. However, most current methods targeting a single analyte are insufficient for the precise recognition of cancer cells. Herein, we propose a cascade amplificati …
Accurate identification of cancer cells is crucial for early cancer diagnosis and treatment. However, most current meth …
Magnetic reversible microfluidic chip and MOF based electrochemical sensor for efficient isolation and detection of tumor derived extracellular vesicles.
Mou L, Feng J, Ye M, Guo Z, Hu X, Wu L, Shu Y. Mou L, et al. Talanta. 2026 May 15;302:129398. doi: 10.1016/j.talanta.2026.129398. Epub 2026 Jan 13. Talanta. 2026. PMID: 41544393
The efficient isolation and detection of tumor-derived extracellular vesicles (T-EVs) are vital for the early diagnosis of cancer. ...This method opens a new avenue for isolation and detection of T-EVs, and has great application prospects in the ear …
The efficient isolation and detection of tumor-derived extracellular vesicles (T-EVs) are vital for the early diagnosis of …
Recent advances in metal-organic framework-based nanozymes for cancer theranostics driven by synthetic innovation and machine learning design.
Yadav S, Sarkar A, Shivalkar S, Fatima F, Thakur SK, Chaudhary A, Samanta SK, Sahoo AK. Yadav S, et al. Colloids Surf B Biointerfaces. 2026 May;261:115463. doi: 10.1016/j.colsurfb.2026.115463. Epub 2026 Jan 20. Colloids Surf B Biointerfaces. 2026. PMID: 41604959 Review.
These properties make them genuinely promising for biomedical applications, particularly in cancer diagnosis and therapy. Recent progress in synthetic design, post-synthetic modification, and machine learning-assisted optimization has enhanced their structural precision an …
These properties make them genuinely promising for biomedical applications, particularly in cancer diagnosis and therapy. Recent prog …
Anti-tumor effect of ardicrenin against MG63 osteosarcoma cells.
Cheng Q. Cheng Q. Bioorg Med Chem Lett. 2026 May;134:130558. doi: 10.1016/j.bmcl.2026.130558. Epub 2026 Jan 21. Bioorg Med Chem Lett. 2026. PMID: 41577017
Cancer remains one of the leading causes of mortality worldwide. As a result, bioactive compounds derived from herbal medicines have gained increasing attention in cancer research. ...
Cancer remains one of the leading causes of mortality worldwide. As a result, bioactive compounds derived from herbal medicines have …
Visualizing intracellular and extracellular cell-mineral interactions in a three-dimensional breast tumor model.
Cohen A, Nativ-Roth E, Vidavsky N. Cohen A, et al. Colloids Surf B Biointerfaces. 2026 May;261:115450. doi: 10.1016/j.colsurfb.2026.115450. Epub 2026 Jan 15. Colloids Surf B Biointerfaces. 2026. PMID: 41558392
Microcalcifications (MCs) in breast tissue, with particularly high prevalence in precancerous lesions, such as ductal carcinoma in situ (DCIS), represent important diagnostic markers for cancer screening. Two primary crystal types, hydroxyapatite (HA) and calcium ox …
Microcalcifications (MCs) in breast tissue, with particularly high prevalence in precancerous lesions, such as ductal carcinoma in situ (DCI …
High efficacy and biocompatibility: Application and biological evaluation of LA67 liposome in colon cancer therapy.
Wang N, Wang J, Yuan Z, Gao Z, Jin M, Cui M. Wang N, et al. Colloids Surf B Biointerfaces. 2026 May;261:115429. doi: 10.1016/j.colsurfb.2026.115429. Epub 2026 Jan 7. Colloids Surf B Biointerfaces. 2026. PMID: 41519010
LA67@Lipo markedly improved internalization by C26 colon cancer cells, effectively inhibiting cell proliferation and inducing apoptosis. In a C26 tumor-bearing mouse model, intravenously administered LA67@Lipo exhibited superior tumor suppression effects. ...In conclusion, …
LA67@Lipo markedly improved internalization by C26 colon cancer cells, effectively inhibiting cell proliferation and inducing apoptos …
CRISPR-Cas12a biosensing technology advances and applications in precision diagnostics and cancer research.
Zang Z, Chen J, Dong Y, Chen L, Yang M, Mu M, Zhou L, Zhang W, Zou G, Liu C. Zang Z, et al. Talanta. 2026 May 1;301:129298. doi: 10.1016/j.talanta.2025.129298. Epub 2026 Jan 6. Talanta. 2026. PMID: 41500123 Review.
These features provide a robust basis for accurate detection of diverse biomarkers. Its detection capabilities include nucleic acid targets such as viral RNA and cancer mutations, as well as non-nucleic acid molecules like exosomes and proteins. ...In onco …
These features provide a robust basis for accurate detection of diverse biomarkers. Its detection capabilities include nucleic …
MGScreener: A multi-view mammography-based model optimized with active learning for breast cancer diagnosis.
Chen Y, Wang P, Zeng J, Tan M, Shan K, Nie L, Xue Y, Wang T. Chen Y, et al. Talanta. 2026 May 1;301:129345. doi: 10.1016/j.talanta.2025.129345. Epub 2026 Jan 3. Talanta. 2026. PMID: 41494265
Breast cancer remains the leading cause of cancer-related mortality among women worldwide. Early screening and accurate subtype classification are critical for guiding clinical decision-making. ...Overall, MGScreener offers a scalable and effective sol …
Breast cancer remains the leading cause of cancer-related mortality among women worldwide. Early screening and a …
Porous composite materials driven by carbohydrate-carbohydrate interactions for efficient enrichment of intact glycopeptides in liver cancer cells.
Song Z, Ti W, Liu M, Liu F, Zhang X, Qing G, Sheng Q, Lan M. Song Z, et al. Talanta. 2026 May 1;301:129272. doi: 10.1016/j.talanta.2025.129272. Epub 2025 Dec 17. Talanta. 2026. PMID: 41448058
Aberrant N-glycosylation plays a key role in liver cancer progression, making glycopeptides promising biomarker candidates. With the increasing awareness of the potential for novel types and features of glycopeptides, there is a pressing need for advanced enrichment materi …
Aberrant N-glycosylation plays a key role in liver cancer progression, making glycopeptides promising biomarker candidates. With the …
Graphene-assisted plasmonic patch for sensitive fluorescence detection of prostate-specific antigen.
Shi HF, Chung YJ, Huang YH, Chern YJ, Darius E, Ching YC, Hsu JY, Liu KK. Shi HF, et al. Talanta. 2026 May 1;301:129279. doi: 10.1016/j.talanta.2025.129279. Epub 2025 Dec 21. Talanta. 2026. PMID: 41435442
Prostate-specific antigen (PSA), an essential biomarker for prostate cancer, was selected as the model target to validate this approach. In our design, plasmonic nanostructures amplified signals from fluorophores conjugated to detection antibodies specifically bound …
Prostate-specific antigen (PSA), an essential biomarker for prostate cancer, was selected as the model target to validate this approa …
Engineered bacterial S-layer enhanced high electron mobility transistor sensors for ultrasensitive detection of tumor antigen.
Tang J, Yang C, Sun J, Li Z, Men Y, Liu Z, Zhang G, Zhang XE, Wang DB. Tang J, et al. Biosens Bioelectron. 2026 Apr 15;298:118382. doi: 10.1016/j.bios.2026.118382. Epub 2026 Jan 8. Biosens Bioelectron. 2026. PMID: 41544455 Free article.
Ultrasensitive and specific detection of low-abundance tumor biomarkers remains a major challenge for early and minimally invasive cancer diagnosis. ...The resulting HEMT sensor detected HE4 across a dynamic linear range (10(-21) to 10(-14) M), identifying pa …
Ultrasensitive and specific detection of low-abundance tumor biomarkers remains a major challenge for early and minimally inva …
Machine learning assisted raman spectroscopy for the classification of ovarian cancer cells.
Li YJ, Sun YC, Li HR, Li MZ, Gao YR, Zhu T, Wen H, Xue CD, Hu XQ, Yang Z, Qin KR. Li YJ, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2026 Apr 15;351:127465. doi: 10.1016/j.saa.2026.127465. Epub 2026 Jan 10. Spectrochim Acta A Mol Biomol Spectrosc. 2026. PMID: 41544326
Ovarian cancer is one of the most lethal gynecological malignancies, asymptomatic early progression, ineffective screening, and high histological heterogeneity. ...Classification performance was assessed across three tasks: (i) discrimination of normal versus …
Ovarian cancer is one of the most lethal gynecological malignancies, asymptomatic early progression, ineffective screening …
A readily interpretable rule involving multiple forms of pairwise molecule comparisons with applications for clinical make-decision of breast cancer management.
Huang X, Chen J, He X. Huang X, et al. J Pharm Biomed Anal. 2026 Apr 15;271:117347. doi: 10.1016/j.jpba.2026.117347. Epub 2026 Jan 7. J Pharm Biomed Anal. 2026. PMID: 41519015
Cells of breast cancer (BC) can metastasize to lymph nodes or other organs and is the high leading cause of female cancer deaths. Efforts to improve the performance of early detection and precise treatment are urgent and important for BC management. In …
Cells of breast cancer (BC) can metastasize to lymph nodes or other organs and is the high leading cause of female cancer deat …
NIR-II conjugated polymer/emodin nanoplatform for mild photothermal therapy/pyroptosis of head and neck squamous cell carcinoma.
Kang Y, Zhang Y, Fan W, Yu L, Yu M, Ding Y, Cai Y, Jiao A, Xu J. Kang Y, et al. J Colloid Interface Sci. 2026 Apr 15;708:139800. doi: 10.1016/j.jcis.2025.139800. Epub 2026 Jan 1. J Colloid Interface Sci. 2026. PMID: 41483565
Moreover, emodin encapsulated within the nanoparticles (NPs) inhibits heat-shock protein 70 (HSP70), thereby disrupting cellular thermoresistance mechanisms and sensitizing cancer cells to MPTT. Additionally, surface functionalization of the nanoparticles with MCT1-targeti …
Moreover, emodin encapsulated within the nanoparticles (NPs) inhibits heat-shock protein 70 (HSP70), thereby disrupting cellular thermoresis …
Photocrosslinkable lung dECM hydrogels promote stiffness-dependent lung cancer growth and chemoresistance.
Hipwood L, Dekker M, Hutmacher DW, Meinert C, McGovern JA. Hipwood L, et al. Mater Today Bio. 2026 Jan 24;37:102838. doi: 10.1016/j.mtbio.2026.102838. eCollection 2026 Apr. Mater Today Bio. 2026. PMID: 41660121 Free PMC article.
Methacrylation and photoinitiation enabled formation of stable LungMA hydrogels with tunable stiffnesses ranging from 1 kPa (healthy lung) to 4 kPa (fibrotic lung). Using A549 non-small-cell lung cancer (NSCLC) cells, we demonstrated that matrix composition and stiffness i …
Methacrylation and photoinitiation enabled formation of stable LungMA hydrogels with tunable stiffnesses ranging from 1 kPa (healthy lung) t …
European Code Against Cancer 5th edition: 14 ways you can help prevent cancer.
Espina C, Ritchie D, Riboli E, Kromhout H, Franceschi S, Lansdorp-Vogelaar I, Marteau TM, Bakogianni I, Vilahur N, Alberts CJ, Ivanus U, Feliu A, D'Souza E, Zeeb H, Mitrou G, Albreht T, Dillner J, Foucaud J, Manczuk M, Martin-Moreno JM, Medema RH, Murray D, Nagy P, Nicula F, Nyangasi M, Steindorf K, Tjønneland A, Cecchini M, Corbex M, Stepien M, Yared W, Carvalho AL, Schüz J; Working Groups of Scientific Experts. Espina C, et al. Lancet Reg Health Eur. 2026 Jan 23;63:101592. doi: 10.1016/j.lanepe.2026.101592. eCollection 2026 Apr. Lancet Reg Health Eur. 2026. PMID: 41631169 Free PMC article. Review.
Despite the growing cancer burden in the European Union, public awareness of effective prevention is low. In response, Europe's Beating Cancer Plan has supported the development of the 5th edition of the European Code Against Cancer (ECAC5). ...Clear evidence …
Despite the growing cancer burden in the European Union, public awareness of effective prevention is low. In response, Europe's Beati …
Inflammation-targeted single-atom nanozymes drive microglial depolarization and inhibit ferroptosis via Sirt-6-xCT-GPX4 axis to attenuate early brain injury following subarachnoid hemorrhage.
Liu B, Xiang C, Zhang X, Guo W, Wu H, Hou F, Ba Y, Zhang X, Chen Z, Feng G, Dang Y, Zhu Y, Gu J. Liu B, et al. Mater Today Bio. 2026 Jan 20;37:102829. doi: 10.1016/j.mtbio.2026.102829. eCollection 2026 Apr. Mater Today Bio. 2026. PMID: 41624511 Free PMC article.
Early brain injury (EBI) has been identified as a key factor leading to the poor prognosis of patients with subarachnoid hemorrhage (SAH). ...
Early brain injury (EBI) has been identified as a key factor leading to the poor prognosis of patients with subarachnoid hemorrhage ( …
Paired clinical 12 lead and apple watch electrocardiogram data repository from childhood cancer survivors authors.
Akbilgic O, Karabayir I, Patterson L, Dixon SB, Mulrooney DA, Ness KK, Hudson MM. Akbilgic O, et al. Data Brief. 2026 Jan 8;65:112452. doi: 10.1016/j.dib.2026.112452. eCollection 2026 Apr. Data Brief. 2026. PMID: 41624307 Free PMC article.
Childhood cancer survivors (CCS), exposed to prior cardiotoxic treatments such as anthracyclines and chest radiation, are at lifelong risk of cardiovascular complications. ...The availability of paired wearable and clinical ECGs enables the development and validation of re …
Childhood cancer survivors (CCS), exposed to prior cardiotoxic treatments such as anthracyclines and chest radiation, are at lifelong …
Application of artificial intelligence in colonoscopy imaging for polyp analysis-A systematic review.
Amirmohammadi E, Shalbaf A, Esteki A, Sadeghi A, Moghadam AR, Moghtaderi M, Moghadam PK. Amirmohammadi E, et al. Comput Methods Programs Biomed. 2026 Apr;277:109239. doi: 10.1016/j.cmpb.2026.109239. Epub 2026 Jan 7. Comput Methods Programs Biomed. 2026. PMID: 41621228 Review.
The colon is a major component of the digestive system, so early detection of colorectal polyps is essential in preventing colorectal cancer, which is a leading cause of cancer-related death worldwide. While colonoscopy remains the gold standard for po …
The colon is a major component of the digestive system, so early detection of colorectal polyps is essential in preventing col …
Advances in the study of the breast carcinoma exosomal microRNAs: From basic mechanisms to clinical applications (Review).
Chen ZM, Huang P, Yang DY, Lin S, Cai SQ. Chen ZM, et al. Int J Oncol. 2026 Apr;68(4):38. doi: 10.3892/ijo.2026.5851. Epub 2026 Jan 30. Int J Oncol. 2026. PMID: 41614405 Review.
Unlike previous reviews that focus on a single function or therapeutic potential of miRNAs, the present review systematically integrated the multilevel role of exosomal miRNAs in breast cancer from the two dimensions of oncogenicity and tumor inhibition and the regulatory …
Unlike previous reviews that focus on a single function or therapeutic potential of miRNAs, the present review systematically integrated the …
Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review).
Zhou P, Ye Q, Huang Y, Feng Y, Zhou L, Xie K. Zhou P, et al. Oncol Rep. 2026 Apr;55(4):57. doi: 10.3892/or.2026.9062. Epub 2026 Jan 30. Oncol Rep. 2026. PMID: 41614401 Free PMC article. Review.
The present review summarizes recent advancements in CTC isolation and detection technologies, explores their clinical applications in immunotherapy, and discusses current challenges alongside potential strategies for improvement. The integration of these technologies into …
The present review summarizes recent advancements in CTC isolation and detection technologies, explores their clinical applications i …
Emerging roles of microfluidics in oral cancer research and clinical translation.
Li ZZ, Wei LY, Cao LM, Wang GR, Luo HY, Zhou K, Zhao XZ, Liu B, Zheng MX, Xu C, Cai B, Bu LL. Li ZZ, et al. Mater Today Bio. 2026 Jan 13;37:102801. doi: 10.1016/j.mtbio.2026.102801. eCollection 2026 Apr. Mater Today Bio. 2026. PMID: 41607856 Free PMC article. Review.
Advances in early diagnosis and treatment strategies for oral cancer patients will significantly improve survival outcomes. ...This review systematically examines the expanding roles of microfluidics in oral cancer research, with a particular focus on microfl …
Advances in early diagnosis and treatment strategies for oral cancer patients will significantly improve survival outcomes. .. …
High throughput HPV genotyping by next generation sequencing for detection of 28 HPV types and 13 sexually transmitted infections: A first community-based cervical cancer screening study from India.
Madhavan Y, Muthukumar V, Ramasubramanian S, Ramshankar V. Madhavan Y, et al. Diagn Microbiol Infect Dis. 2026 Apr;114(4):117278. doi: 10.1016/j.diagmicrobio.2026.117278. Epub 2026 Jan 16. Diagn Microbiol Infect Dis. 2026. PMID: 41576634
Comprehensive molecular approaches are needed to better characterize HPV genotypes and co-infections in community screening settings. METHODS: This study evaluated the analytical performance of a next-generation sequencing (NGS)-based HPV-STI assay in comparison with the c …
Comprehensive molecular approaches are needed to better characterize HPV genotypes and co-infections in community screening settings. …
Reduction in Time-to-Diagnosis for Lung Cancer Resulting From Implementation of a Formal Incidental Pulmonary Nodule (IPN) Program Compared With Traditional Referral Pathways.
Mahajan AK, Ochoa Cuba MA, Collar N, Pullen K, Muldowney F, Shah N, Patel PP, Duong DK, Suzuki K, Subramanian M, Nader A, Parne M, Weyant MJ, Deeken J. Mahajan AK, et al. J Bronchology Interv Pulmonol. 2026 Jan 19;33(2):e1056. doi: 10.1097/LBR.0000000000001056. eCollection 2026 Apr 1. J Bronchology Interv Pulmonol. 2026. PMID: 41549999
Ninety-six of these patients (1%) were diagnosed with cancer following nodule biopsy. Eighty-one of the patients (84%), making up the FIP group, were diagnosed with primary lung cancer. Twenty-one of the 81 primary lung cancer patients in the FIP group (27%) …
Ninety-six of these patients (1%) were diagnosed with cancer following nodule biopsy. Eighty-one of the patients (84%), making up the …
Construction of a multilayer fluorescence-encoded single quantum dot-based FRET nanosensor for simple and sensitive monitoring of circular RNA in clinical tissues.
Wang Q, Hu J, Lu J, Zhang CY. Wang Q, et al. Biosens Bioelectron. 2026 Apr 1;297:118401. doi: 10.1016/j.bios.2026.118401. Epub 2026 Jan 13. Biosens Bioelectron. 2026. PMID: 41538967
The accurate and sensitive monitoring of circRNAs is essential for early disease diagnosis and therapeutic monitoring. Herein, we construct a multilayer fluorescence encoding-mediated single QD-based Forster resonance energy-transfer (FRET) nanosensor for the simple and se …
The accurate and sensitive monitoring of circRNAs is essential for early disease diagnosis and therapeutic monitoring. Herein, we con …
Impact of asynchronous online cancer education for nurses on practice outcomes: A systematic review using the kirkpatrick evaluation model.
Cope H, Campbell K. Cope H, et al. Nurse Educ Today. 2026 Apr;159:106964. doi: 10.1016/j.nedt.2025.106964. Epub 2025 Dec 30. Nurse Educ Today. 2026. PMID: 41506090 Free article.
BACKGROUND: Continuing education is critical for oncology nurses to enable the delivery of safe, efficient, specialist care based on current evidence-based guidelines. ...Behavioural change was objectively measured in two (7 %) studies, evaluating screening rates an …
BACKGROUND: Continuing education is critical for oncology nurses to enable the delivery of safe, efficient, specialist care based on …
Logic-gated CRISPR-Cas12a assay with engineered signal amplification for sensitive multiplexed detection of HCC miRNAs.
Jiang H, Yang J, Qian C, Li A, Liu Y, Zhang F, Deng Y, Duan J, Lv X. Jiang H, et al. Biosens Bioelectron. 2026 Apr 1;297:118376. doi: 10.1016/j.bios.2026.118376. Epub 2026 Jan 6. Biosens Bioelectron. 2026. PMID: 41506042
To address this, we established a novel biosensing platform that integrates circle-to-circle AND logic gate circuit with an engineered CRISPR-Cas system for the early screening of hepatocellular carcinoma. In this design, the logic gate processes multiple miRNA inpu …
To address this, we established a novel biosensing platform that integrates circle-to-circle AND logic gate circuit with an engineered CRISP …
Targeted anticancer potential of oxazole derivative against breast cancer: Synthesis, molecular docking, dynamics simulation, and in vitro evaluation on ERBB3 receptor.
Xu J, Zhu D, Rajalakshmi K, Deshpande M, Kiruthiga N, Theivendren P, Muthusamy S, Wu S, Zhao W. Xu J, et al. Comput Biol Chem. 2026 Apr;121:108859. doi: 10.1016/j.compbiolchem.2025.108859. Epub 2025 Dec 23. Comput Biol Chem. 2026. PMID: 41468763
The study investigates 5- ((2-nitrobenzylidene) amino 2-phenyloxazole-4-carbonitrile (PS13), a derivative of the oxazole that was designed to block the ERBB3 receptor that plays a role in breast cancer development. The syntheses of PS13 were performed in two steps due to c …
The study investigates 5- ((2-nitrobenzylidene) amino 2-phenyloxazole-4-carbonitrile (PS13), a derivative of the oxazole that was designed t …
Biosensors based on liquid biopsy for clinical cancer diagnosis.
Ma K, Sun X, Liang C, Yi M, Shen L, Zhang J, Wang Z. Ma K, et al. Biosens Bioelectron. 2026 Apr 1;297:118337. doi: 10.1016/j.bios.2025.118337. Epub 2025 Dec 22. Biosens Bioelectron. 2026. PMID: 41456389 Review.
Early detection is paramount for effective intervention, significantly improving patient survival rates by enabling timely treatment when therapeutic options are most viable. ...Consequently, the development of accessible and accurate diagnostic tools is of profound …
Early detection is paramount for effective intervention, significantly improving patient survival rates by enabling timely tre …
Design and synthesis of Tetrahydroindeno[4,5-c]chromen-4(3H)-one derivatives as antiproliferative agents for prostate Cancer cells.
Chan HY, Huang PS, Chiu PF, Lin TS, Huang LJ, Liang PH, Guh JH, Lin MH. Chan HY, et al. Bioorg Med Chem Lett. 2026 Apr;133:130515. doi: 10.1016/j.bmcl.2025.130515. Epub 2025 Dec 24. Bioorg Med Chem Lett. 2026. PMID: 41453691
Abiraterone, a CYP17A1 inhibitor, is approved by the FDA for castration-resistance prostate cancer. To mimic the structure of abiraterone, we designed and synthesized nine tetrahydroindeno[4,5-c]chromen-4(3H)-one derivatives with pyridine congeners at C-1 position. ...
Abiraterone, a CYP17A1 inhibitor, is approved by the FDA for castration-resistance prostate cancer. To mimic the structure of abirate …
Are older adults scheduled for lung cancer screening interested in trying electronic cigarettes when conventional smoking cessation treatment fails? A cross-sectional survey.
Avila JC, Tripathi N, Marotta CJ, McCann CE, Reyen M, Haas JS, Park ER, Rigotti NA. Avila JC, et al. Addict Behav. 2026 Apr;175:108592. doi: 10.1016/j.addbeh.2025.108592. Epub 2025 Dec 22. Addict Behav. 2026. PMID: 41447891
INTRODUCTION: Lung cancer screening (LCS) provides an opportunity to offer tobacco cessation treatment, but most people who smoke are unable to quit, even with support. ...
INTRODUCTION: Lung cancer screening (LCS) provides an opportunity to offer tobacco cessation treatment, but most people who sm …
Promoting endogenous iron mediated ferroptosis for cancer therapy through gene interference and reactive oxygen species amplification.
Li S, Wang W, Kou S, Ding X, Jin J, Yang Z, Hua D. Li S, et al. J Colloid Interface Sci. 2026 Apr;707:139717. doi: 10.1016/j.jcis.2025.139717. Epub 2025 Dec 18. J Colloid Interface Sci. 2026. PMID: 41422761
Ferroptosis, an iron-dependent form of regulated cell death, has emerged as an attractive strategy in cancer therapy. However, current approaches that deliver exogenous iron to induce ferroptosis suffer from off-target toxicity and are often thwarted by tumor cell iron-eff …
Ferroptosis, an iron-dependent form of regulated cell death, has emerged as an attractive strategy in cancer therapy. However, curren …
Multi-omics profiling of ACOX3 unveils pan-cancer clinical biomarker potential.
Wang WL, Xiong Q, Ma B, Liang XH, Tang YL. Wang WL, et al. Comput Biol Chem. 2026 Apr;121:108844. doi: 10.1016/j.compbiolchem.2025.108844. Epub 2025 Dec 13. Comput Biol Chem. 2026. PMID: 41411722
OBJECTIVE: This study aims to comprehensively characterize ACOX3 as a novel pan-cancer biomarker by assessing its expression heterogeneity, clinical relevance, tumor-immune interactions and therapeutic potential across multiple cancer types. ...CONCLUSION: ACOX3 rep …
OBJECTIVE: This study aims to comprehensively characterize ACOX3 as a novel pan-cancer biomarker by assessing its expression heteroge …
Towards canine immunotherapy models: Monoclonal antibodies with redox regulated epitopes targeting TIM3 attenuate Galectin-9 binding.
Brydon J, Krejcir R, Grima M, Zavadil-Kokas F, Kuncova Z, Sousan S, Pflughaupt RL, Thomson JR, Davies P, Senior E, Wood GA, Ball KL, Saliba D, Argyle DJ, Vojtesek B, Hupp T, Parys M. Brydon J, et al. Anal Biochem. 2026 Apr;711:116033. doi: 10.1016/j.ab.2025.116033. Epub 2025 Dec 15. Anal Biochem. 2026. PMID: 41407064 Free article.
The TIM3 receptor acts as an immune checkpoint protein. Canine cancers exhibit higher pan-cancer penetrance of TIM3 compared to PD1, highlighting the potential of TIM3 as a compelling target in comparative immuno-oncology. ...Alternating rounds of biopanning were pe …
The TIM3 receptor acts as an immune checkpoint protein. Canine cancers exhibit higher pan-cancer penetrance of TIM3 compared to PD1, …
Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer.
Chen X, Wong I, Cong M, Chen W, Jin M, Wang H, Chen F, Zhang Q, Liu K, Liu Y, Wang R, Wang J, Wang J. Chen X, et al. Phytochemistry. 2026 Apr;244:114746. doi: 10.1016/j.phytochem.2025.114746. Epub 2025 Dec 13. Phytochemistry. 2026. PMID: 41397549
Additionally, oxalicpyridones A-C (1-3) inhibited the viability of several small-cell lung cancer (SCLC) cell lines in a dose-dependent manner. Among them, oxalicpyridone A (1) not only inhibited proliferation, induced apoptosis, and suppressed metastasis of SCLC cells in …
Additionally, oxalicpyridones A-C (1-3) inhibited the viability of several small-cell lung cancer (SCLC) cell lines in a dose-depende …
Application value of prostate-specific antigen density combined with multiparametric MRI in early diagnosis of prostate cancer.
Wu D, Tang Z. Wu D, et al. Magn Reson Imaging. 2026 Apr;127:110593. doi: 10.1016/j.mri.2025.110593. Epub 2025 Dec 11. Magn Reson Imaging. 2026. PMID: 41389905
BACKGROUND: Diagnosis of prostate cancer in the PSA gray zone (4-10 ng/mL) and PI-RADS 3 cases remains challenging. Although multiparametric MRI (mpMRI) is widely used, its diagnostic accuracy is limited by inter-reader variability and the lack of integration with clinical …
BACKGROUND: Diagnosis of prostate cancer in the PSA gray zone (4-10 ng/mL) and PI-RADS 3 cases remains challenging. Although multipar …
Enzyme-based biosensors: emerging tools for advanced biomedical applications.
Bocina E, Cocuzza C, Vincenzi C, Fino D, Cauda V, Piumetti M. Bocina E, et al. Talanta. 2026 Apr 1;300:129241. doi: 10.1016/j.talanta.2025.129241. Epub 2025 Dec 11. Talanta. 2026. PMID: 41389693 Free article. Review.
Enzyme-based biosensor can become important tools for disease monitoring and drug screening in a faster and cost-effective manner. This works shows the importance of these molecules, giving particular attention to their role in cancer development and neurodegenerati …
Enzyme-based biosensor can become important tools for disease monitoring and drug screening in a faster and cost-effective manner. Th …
Repeatability and reproducibility of maximum diameter measurements of prostate lesions on MRI with repositioning and variation of imaging sequences: A test-retest study.
Zhang KS, Glemser PA, Neelsen CJO, Wennmann M, Rotkopf LT, Netzer N, Meinzer C, Hielscher T, Weru V, Görtz M, Stenzinger A, Hohenfellner M, Schlemmer HP, Bonekamp D. Zhang KS, et al. Magn Reson Imaging. 2026 Apr;127:110578. doi: 10.1016/j.mri.2025.110578. Epub 2025 Nov 27. Magn Reson Imaging. 2026. PMID: 41317885 Free article.
Molecular targeted therapies, omics, and AI based theranostics approaches for the treatment of prostate cancer.
Khan S, Nema P, Kashaw V, Kashaw SK. Khan S, et al. Talanta. 2026 Apr 1;300:129132. doi: 10.1016/j.talanta.2025.129132. Epub 2025 Nov 20. Talanta. 2026. PMID: 41317478 Review.
The disease often progresses silently in its early stages, underscoring the critical need for timely screening and awareness. importance of early detection and the role of prostate specific antigen (PSA) testing, digital rectal examinations (DRE), and …
The disease often progresses silently in its early stages, underscoring the critical need for timely screening and awareness. …
White Light, Magnifying Endoscopy, Endocytoscopy, and Artificial Intelligence in Diagnosis of Early Colorectal Cancer: A Comparative Study.
Tamura E, Kudo SE, Iwasaki S, Semba S, Shibuya T, Kato S, Kuroki T, Sato Y, Sakurai T, Ogawa Y, Kouyama Y, Maeda Y, Ichimasa K, Ogata N, Hayashi T, Wakamura K, Miyachi H, Baba T, Ishida F, Nemoto T, Misawa M. Tamura E, et al. DEN Open. 2025 Nov 17;6(1):e70240. doi: 10.1002/deo2.70240. eCollection 2026 Apr. DEN Open. 2025. PMID: 41262550 Free PMC article.
OBJECTIVES: Early detection of colorectal cancer is critical for improving prognosis. However, assessing invasion depth-distinguishing between superficial cancer (T1a) and deep submucosal invasive cancer (T1b)-remains challenging. ...This approa …
OBJECTIVES: Early detection of colorectal cancer is critical for improving prognosis. However, assessing invasion depth …
Controlled trial of cervical cancer screening frequency among human-papillomavirus-vaccinated women.
Ortega Llobet M, Gray P, Baussano I, Elfström KM, Eriksson T, Lagheden C, Nieminen P, Söderlund-Strand A, Dillner J, Pimenoff VN, Lehtinen M. Ortega Llobet M, et al. Int J Cancer. 2026 Apr 1;158(7):1941-1951. doi: 10.1002/ijc.70229. Epub 2025 Nov 7. Int J Cancer. 2026. PMID: 41203578 Free PMC article. Clinical Trial.
We report a trial to assess the effectiveness of cervical screening frequency among women HPV-vaccinated as early adolescents (NCT02149030). In 2013, 5626 1992-1995-born women, who had received three doses of the HPV16/18 vaccine at ages 12-15 between 2007 and 2010 …
We report a trial to assess the effectiveness of cervical screening frequency among women HPV-vaccinated as early adolescents …
Geriatric 8 Score Predicts Functional Decline After Endoscopic Resection for Upper Gastrointestinal Neoplasms in Older Adults: A Prospective Cohort Study.
Okubo Y, Inoue T, Yoshii S, Arao M, Nakahira H, Iwatsubo T, Matsueda K, Kato M, Shichijo S, Kanesaka T, Yamamoto S, Higashino K, Uedo N, Michida T, Ishihara R. Okubo Y, et al. DEN Open. 2025 Oct 18;6(1):e70226. doi: 10.1002/deo2.70226. eCollection 2026 Apr. DEN Open. 2025. PMID: 41113162 Free PMC article.
OBJECTIVES: Endoscopic resection (ER) is used in older patients to treat upper gastrointestinal (UGI) neoplasms due to minimal invasiveness and excellent short-term therapeutic outcomes. However, its impact on functional outcomes remains unclear. ...Scores of geriatric ass …
OBJECTIVES: Endoscopic resection (ER) is used in older patients to treat upper gastrointestinal (UGI) neoplasms due to minimal invasi …
When Endoscopic Sedation is Not an Option: Insights From a Multicenter on-site Survey on Tolerance for Japanese Gastric Cancer Screening.
Inoki K, Chiba T, Miura K, Tagawa T, Aoyagi Y, Takeuchi Y, Moriyama N, Kuraoka K, Ohara T, Haruhara Y, Mizuki A, Satio J, Hagisawa Y, Ono N, Takayama N, Onishi T, Mishima A, Suzuki N, Kikuchi K, Katagiri A, Yamamura F, Ohde S, Inoue E, Matsuda T, Yoshida H. Inoki K, et al. DEN Open. 2025 Aug 11;6(1):e70179. doi: 10.1002/deo2.70179. eCollection 2026 Apr. DEN Open. 2025. PMID: 40792097 Free PMC article.
OBJECTIVES: Esophagogastroduodenoscopy (EGD) is widely used for gastric cancer (GC) screening in Japan; however, sedation during EGD is not recommended. We aimed to assess the tolerability of unsedated EGD (USEGD) in the Japanese population. ...Supportive measures f …
OBJECTIVES: Esophagogastroduodenoscopy (EGD) is widely used for gastric cancer (GC) screening in Japan; however, sedation duri …
Assessing the effectiveness of texture and color enhancement imaging versus white-light endoscopy in detecting gastrointestinal lesions: A systematic review and meta-analysis.
Shahzil M, Kashif TB, Jamil Z, Khaqan MA, Munir L, Amjad Z, Faisal MS, Chaudhary AJ, Ali H, Khan S, Enofe I. Shahzil M, et al. DEN Open. 2025 Apr 30;6(1):e70128. doi: 10.1002/deo2.70128. eCollection 2026 Apr. DEN Open. 2025. PMID: 40313348 Free PMC article. Review.
INTRODUCTION: Gastrointestinal cancers account for 26% of cancer incidence and 35% of cancer-related deaths globally. Early detection is crucial but often limited by white light endoscopy (WLE), which misses subtle lesions. ...TXI also enhanced adenoma …
INTRODUCTION: Gastrointestinal cancers account for 26% of cancer incidence and 35% of cancer-related deaths globally. Early …
Eight-channel vertical-graphene antenna immunosensor array for rapid detection of CYFRA 21-1 in human serum.
Chen Z, Xuan X, Li H, Dong X, Xiao T, Jiang D, Li C, Li H, Li M. Chen Z, et al. Biosens Bioelectron. 2026 Mar 15;296:118329. doi: 10.1016/j.bios.2025.118329. Epub 2025 Dec 22. Biosens Bioelectron. 2026. PMID: 41448042
The response times for the single sensor and the eight-channel array were 2 and 5 min, respectively. For the detection of CYFRA21-1, a wide linear dynamic range was achieved (0.1-12000 pg mL(-1)), with a detection limit as low as 35.12 fg mL(-1). The sensor array sy …
The response times for the single sensor and the eight-channel array were 2 and 5 min, respectively. For the detection of CYFRA21-1, …
Optimization of a microfluidic system for automated detection of Cholangiocarcinoma cells in bile.
Su YT, Tsai YC, Huang CJ, Chiang NJ, Bandaru A, Hung SC, Shan YS, Lee GB. Su YT, et al. Biosens Bioelectron. 2026 Mar 15;296:118330. doi: 10.1016/j.bios.2025.118330. Epub 2025 Dec 19. Biosens Bioelectron. 2026. PMID: 41442926
Cholangiocarcinoma (CCA) remains a clinical challenge despite ongoing advancements in its characterization and diagnostics. Early diagnosis of CCA is particularly difficult due to its anatomically deep location; this often results in advanced-stage diagnoses and consequent …
Cholangiocarcinoma (CCA) remains a clinical challenge despite ongoing advancements in its characterization and diagnostics. Early dia …
A hybrid framework integrating serum biochemical markers and FTIR spectroscopy with machine learning for early cancer screening.
Zhang Z, Zhang R, Ma X, Yang C, Fu B, Zhang Z, Cao H, Gao Y. Zhang Z, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2026 Mar 15;349:127337. doi: 10.1016/j.saa.2025.127337. Epub 2025 Dec 17. Spectrochim Acta A Mol Biomol Spectrosc. 2026. PMID: 41442913
Early detection of cancer remains a key challenge in clinical diagnosis. This study explored two serum sample-based early cancer screening methods: one based on biochemical parameters and the other based on infrared spectroscopy da …
Early detection of cancer remains a key challenge in clinical diagnosis. This study explored two serum sample-ba …
A spatially-programmed DNA nanoplatform for multiplexed and orthogonal miRNA profiling enables robust diagnosis of colorectal cancer.
Ma L, Wu N, Hou A, Hu X, Zhou Z, Jiang Z, Wang S, Li M, Xue C, Shen Z, Dong Y, Wu R. Ma L, et al. Biosens Bioelectron. 2026 Mar 15;296:118310. doi: 10.1016/j.bios.2025.118310. Epub 2025 Dec 11. Biosens Bioelectron. 2026. PMID: 41391297
Sensitive and simultaneous detection of a panel of microRNAs (miRNAs) is crucial for the precise early diagnosis of colorectal cancer (CRC) in complex environments and clinical samples. ...The sensing platform exhibited a strong linear response across both lo …
Sensitive and simultaneous detection of a panel of microRNAs (miRNAs) is crucial for the precise early diagnosis of colorectal …
Computer-intelligent customized CHA-graphene oxide-DNA circuit for multiplex miRNA detection and accurate cancer cell identification.
Liu M, Song Y, Liu M, Lou Z, Deng D, Yu Y, Yan X, Luo L. Liu M, et al. Biosens Bioelectron. 2026 Mar 15;296:118303. doi: 10.1016/j.bios.2025.118303. Epub 2025 Dec 11. Biosens Bioelectron. 2026. PMID: 41391296
In the analysis of cancer molecular subtypes, miRNAs are important tumor markers. Although artificially designed DNA circuits have been widely used and exhibited high sensitivity in miRNA detection, the drawbacks of low efficiency and lack of high throughput restric …
In the analysis of cancer molecular subtypes, miRNAs are important tumor markers. Although artificially designed DNA circuits have be …
Cross-modality fusion of hematology-based digital and molecular biomarkers for intelligent epidemiological screening and surveillance of hepatocellular carcinoma.
Cheng N, Tao Y, Yang J, Shen C, Zhang C, Lou B. Cheng N, et al. Biosens Bioelectron. 2026 Mar 15;296:118290. doi: 10.1016/j.bios.2025.118290. Epub 2025 Dec 3. Biosens Bioelectron. 2026. PMID: 41389775
Early detection of hepatocellular carcinoma (HCC) remains a critical challenge due to the disease's complexity and the limitations of current screening and surveillance methods, which are often invasive, costly, or lack adequate sensitivity. ...This study dem …
Early detection of hepatocellular carcinoma (HCC) remains a critical challenge due to the disease's complexity and the limitat …
KRAS-G12C: The neglected biomarker to detect patients with MUTYH-associated polyposis.
Medeiros ABD, Dos Santos GO, Casali-da-Rocha JC, Junior SA, Souza E Silva V, Berardinelli GN, Antoniazzi AP, Reis RM, Carraro DM, Torrezan GT. Medeiros ABD, et al. Int J Cancer. 2026 Mar 15;158(6):1588-1598. doi: 10.1002/ijc.70281. Epub 2025 Dec 5. Int J Cancer. 2026. PMID: 41347765 Free PMC article.
MUTYH-associated polyposis (MAP) is an underdiagnosed recessive syndrome that predisposes individuals to colorectal cancer (CRC) and exhibits phenotypic variability. Biallelic MUTYH inactivation leads to a somatic mutational signature with frequent KRAS-G12C mutations; how …
MUTYH-associated polyposis (MAP) is an underdiagnosed recessive syndrome that predisposes individuals to colorectal cancer (CRC) and …
Doppel as an early-stage biomarker promoting EMT and dissemination in ovarian cancers.
Azam Z, Zhang X, Wahab R, Hasan MM, Dhadhal S, Kang B, Hassan MM, Karim M, Choi JU, Rana M, Zhang JY, Roy S, Byun Y, Kim IS, Song JY, Toy EP, Reddy SY, Alam F, Al-Hilal TA. Azam Z, et al. Int J Cancer. 2026 Mar 15;158(6):1755-1768. doi: 10.1002/ijc.70268. Epub 2025 Nov 29. Int J Cancer. 2026. PMID: 41317023 Free PMC article.
Detecting ovarian cancer (OC) early using existing biomarkers, for example, cancer antigen 125 (CA125), is challenging due to its ubiquitous expression in many tissues. ...Serum Doppel levels can distinguish OC with high sensitivity and specificity (sensitivi …
Detecting ovarian cancer (OC) early using existing biomarkers, for example, cancer antigen 125 (CA125), is challenging …
The cervical cancer screening program in the North of Portugal: Outcomes after nearly two decades of coexistence with the human papillomavirus vaccine.
Sá P, Monteiro P, Henrique R, Lunet N. Sá P, et al. Int J Cancer. 2026 Mar 15;158(6):1577-1587. doi: 10.1002/ijc.70196. Epub 2025 Nov 3. Int J Cancer. 2026. PMID: 41181943
As the first vaccinated cohorts are gradually becoming eligible for cervical cancer screening (CCS), changes in the distribution of high-risk human papillomavirus (hrHPV) infection and associated disease endpoints are expected to occur. ...
As the first vaccinated cohorts are gradually becoming eligible for cervical cancer screening (CCS), changes in the distributi …
Using period analysis for timely assessment and prediction of 5-year relative survival for childhood cancer patients from Taizhou, Eastern China.
Bing X, Försti A, Zhao X, Lei Q, Wang L, Zhang L, Chen X, Yang J, Chen T. Bing X, et al. Int J Cancer. 2026 Mar 15;158(6):1555-1563. doi: 10.1002/ijc.70192. Epub 2025 Oct 11. Int J Cancer. 2026. PMID: 41074584
Timely population-based cancer registry data with accurate 5-year relative survival (RS) estimates is essential for childhood cancer control. ...These findings provide essential data for evaluating the effectiveness of childhood cancer early detecti …
Timely population-based cancer registry data with accurate 5-year relative survival (RS) estimates is essential for childhood canc …
Optimizing colonoscopy-based colorectal cancer screening by low-barrier, low-threshold pretesting.
Heisser T, Cardoso R, Niedermaier T, Hoffmeister M, Brenner H. Heisser T, et al. Int J Cancer. 2026 Mar 15;158(6):1608-1616. doi: 10.1002/ijc.70187. Epub 2025 Oct 9. Int J Cancer. 2026. PMID: 41065462 Free PMC article.
Using COSIMO, a previously validated simulation tool, we compared outcomes of gateopener screening to those of conventional FIT- or colonoscopy-based screening strategies. Gateopener screening was modelled using SENTiFIT-FOB Gold as exemplary 'gateopener' FIT …
Using COSIMO, a previously validated simulation tool, we compared outcomes of gateopener screening to those of conventional FIT- or c …
Oral cancer risk stratification: A cross-sectional population-based screening study in Northeast India.
Oswal K, Barman S, Kerr AR, Zaman M, Patowary J, Barali DD, Barman N, Das A, Nadkar U, Dikshit R, Gallagher JE, Lingen MW, Muwonge R, Castle PE, Cheung LC, Yu KJ, Chaturvedi AK, Purushotham A. Oswal K, et al. Int J Cancer. 2026 Mar 15;158(6):1517-1527. doi: 10.1002/ijc.70160. Epub 2025 Sep 19. Int J Cancer. 2026. PMID: 40974103 Free PMC article.
We conducted a cross-sectional oral cancer screening study in Northeast India to develop and validate an oral precancer/cancer risk prediction model. ...Model validation was conducted internally and externally (Kerala oral cancer screening trial …
We conducted a cross-sectional oral cancer screening study in Northeast India to develop and validate an oral precancer/can …
Sex and organ-specific risk and temporal trends of human papillomavirus-associated anogenital cancer among solid organ transplant recipients in the United States.
Cui J, Mukherjee A, Patel PG, Junkins A, Agarwal G, Giri S, Griffin R, Sudenga SL, Shrestha S. Cui J, et al. Int J Cancer. 2026 Mar 15;158(6):1507-1516. doi: 10.1002/ijc.70158. Epub 2025 Sep 15. Int J Cancer. 2026. PMID: 40952413
Risk stratification and temporal trends of cancer incidence will help early detection, evaluation, management, and treatment of post-transplant cancers over time. ...These data can help develop risk stratification for HPV-associated cancer screening …
Risk stratification and temporal trends of cancer incidence will help early detection, evaluation, management, and trea …
Discover of a highly effective covalent inhibitor of CDK6 for triple-negative breast cancer treatment.
Zeng J, Yin F, Fan Y, Zheng K, Zhang Z, Liu L, Jiang R, Li N, Liu F, Xia C, Wang C. Zeng J, et al. Eur J Med Chem. 2026 Mar 5;305:118565. doi: 10.1016/j.ejmech.2026.118565. Epub 2026 Jan 15. Eur J Med Chem. 2026. PMID: 41548293
CDK4/6 inhibitors are effective in treating HR+/HER2- breast cancer, but they have limitations in treating TNBC and drug-resistant breast cancer. To overcome this challenge, we designed and synthesized a series of novel covalent inhibitors for CDK6 that contain the …
CDK4/6 inhibitors are effective in treating HR+/HER2- breast cancer, but they have limitations in treating TNBC and drug-resistant br …
Discovery of WWZ-11-098: a rigid and selective CDK6 degrader.
Zhang W, Wen J, Wu Y, Xuan Y, Han Q, Chen X, Yu J, Yu H, Jiang B. Zhang W, et al. Eur J Med Chem. 2026 Mar 5;305:118569. doi: 10.1016/j.ejmech.2026.118569. Epub 2026 Jan 12. Eur J Med Chem. 2026. PMID: 41548292
Dysregulation of the cell cycle, a hallmark of cancer, frequently involves aberrant activation of cyclin D-CDK4/6 complexes. Although dual-CDK4/6 inhibitors are effective in advanced hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) …
Dysregulation of the cell cycle, a hallmark of cancer, frequently involves aberrant activation of cyclin D-CDK4/6 complexes. Although …
Small-molecule modulators of the androgen receptor N-terminal domain: Advances in medicinal chemistry for prostate cancer.
Sekhon I, Ashong D, Chen G, Chen QH. Sekhon I, et al. Eur J Med Chem. 2026 Mar 5;305:118580. doi: 10.1016/j.ejmech.2026.118580. Epub 2026 Jan 13. Eur J Med Chem. 2026. PMID: 41544581 Free article. Review.
Resistance to androgen receptor (AR) therapies in prostate cancer frequently arises from ligand-binding domain (LBD) mutations or the expression of LBD-truncated splice variants such as AR-V7. ...Disrupting critical protein-protein interactions, such as those between the A …
Resistance to androgen receptor (AR) therapies in prostate cancer frequently arises from ligand-binding domain (LBD) mutations or the …
Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.
Fang Z, Zhan S, Mao C, Zhang N, Zhao X, Huang Y, Ding W, Ma Z. Fang Z, et al. Eur J Med Chem. 2026 Mar 5;305:118573. doi: 10.1016/j.ejmech.2026.118573. Epub 2026 Jan 12. Eur J Med Chem. 2026. PMID: 41544579
Through virtual screening followed by structure-guided chemical modification, we identified H5 as a BRD4 inhibitor. ...Collectively, H5 emerges as a highly promising BRD4-targeted candidate for colorectal cancer treatment....
Through virtual screening followed by structure-guided chemical modification, we identified H5 as a BRD4 inhibitor. ...Collectively, …
Design, synthesis, and evaluation of unsymmetrical trifluoromethyl-containing bisindolylmethane derivatives inducing endoplasmic reticulum stress in human lung adenocarcinoma.
Zhu W, Huang J, Deng X, Chen Y, Ye L, Tian S, Zhou L, Weng J, Liu Y. Zhu W, et al. Eur J Med Chem. 2026 Mar 5;305:118564. doi: 10.1016/j.ejmech.2026.118564. Epub 2026 Jan 9. Eur J Med Chem. 2026. PMID: 41534435
Bisindolylmethane (BIM) is an important alkaloid derived from cruciferous plants that exhibits anti-cancer biological activity. Molecules with a BIM skeleton have long been widely recognized by medicinal chemists. ...These novel BIMs inhibit various cancer cells, es …
Bisindolylmethane (BIM) is an important alkaloid derived from cruciferous plants that exhibits anti-cancer biological activity. Molec …
A novel luteinizing hormone-releasing hormone (LHRH) receptor-targeting peptide LHRH-III': Design and application for targeted breast cancer therapy.
Qiu B, Fan R, Si G, Wang J, Wang K, Zheng G, Tian X. Qiu B, et al. Eur J Med Chem. 2026 Mar 5;305:118563. doi: 10.1016/j.ejmech.2026.118563. Epub 2026 Jan 7. Eur J Med Chem. 2026. PMID: 41518959
Breast cancer is one of the most common malignant tumors among women, with approximately 50-60 % of cases overexpressing the luteinizing hormone-releasing hormone receptor (LHRH-R), making it an important therapeutic target. ...In summary, the novel targeting peptide LHRH- …
Breast cancer is one of the most common malignant tumors among women, with approximately 50-60 % of cases overexpressing the luteiniz …
Tanshinone IIA derivatives inhibits colorectal cancer growth by targeting pyruvate kinase M2.
Bai J, Liu S, Mang Z, Duan X, Song C, Tian W. Bai J, et al. Eur J Med Chem. 2026 Mar 5;305:118477. doi: 10.1016/j.ejmech.2025.118477. Epub 2025 Dec 13. Eur J Med Chem. 2026. PMID: 41512539
Pyruvate kinase M2 (PKM2), a key glycolytic enzyme, is frequently overexpressed in colorectal cancer (CRC) and has emerged as a promising therapeutic target. In this study, a series of Tanshinone IIA derivatives were designed and synthesized through simultaneous modificati …
Pyruvate kinase M2 (PKM2), a key glycolytic enzyme, is frequently overexpressed in colorectal cancer (CRC) and has emerged as a promi …
Recent progress of napabucasin as privileged scaffold in the discovery of anticancer agents.
Yang X, Ma G. Yang X, et al. Eur J Med Chem. 2026 Mar 5;305:118559. doi: 10.1016/j.ejmech.2026.118559. Epub 2026 Jan 4. Eur J Med Chem. 2026. PMID: 41494471 Review.
Cancer is a major health issue worldwide, necessitating the development of novel treatments because treating this disease is challenging. ...By conducting multidimensional assessments, we propose feasible directions for developing napabucasins with improved pharmacological …
Cancer is a major health issue worldwide, necessitating the development of novel treatments because treating this disease is challeng …
Promiscuously bioactive compounds are prevalent in widely used commercial drug repurposing libraries.
Hu H, Bowers J, Shumate J, Scampavia L, Spicer TP, Yi X, Antolin AA, Baell JB. Hu H, et al. Eur J Med Chem. 2026 Mar 5;305:118550. doi: 10.1016/j.ejmech.2025.118550. Epub 2025 Dec 31. Eur J Med Chem. 2026. PMID: 41494469 Review.
The discovery of new therapeutics typically begins with screening compound collections against specific disease targets to identify bioactive small molecules. ...We call upon the biomedical community to implement rigorous validation processes for screening hits and …
The discovery of new therapeutics typically begins with screening compound collections against specific disease targets to identify b …
Comprehensive insights about accurate susceptibility detection towards hydrogen sulfide for food safety and disease diagnosis.
Zeng X, Chen W, Yang J, Zhang Q, Deng W, Huang Z, Li D. Zeng X, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2026 Mar 5;348(Pt 1):127061. doi: 10.1016/j.saa.2025.127061. Epub 2025 Oct 18. Spectrochim Acta A Mol Biomol Spectrosc. 2026. PMID: 41138624 Review.
RESULTS: With the rapid advancement of fluorescence imaging technology, small-molecule fluorescent probes have emerged as one of the most powerful tools for visualizing biological signaling processes and monitoring food safety, owing to their non-invasiveness, high selectivity, a …
RESULTS: With the rapid advancement of fluorescence imaging technology, small-molecule fluorescent probes have emerged as one of the most po …
Cancer Prevention and Control.
Pollock BH. Pollock BH. Prim Care. 2026 Mar;53(1):31-39. doi: 10.1016/j.pop.2025.09.004. Epub 2025 Nov 13. Prim Care. 2026. PMID: 41656018 Review.
Primary care providers (PCPs) play a crucial role in promoting cancer prevention practices. Prevention practices aim to reduce cancer incidence and mortality while improving long-term outcomes for patients who develop cancer. ...Barriers to implementation dis …
Primary care providers (PCPs) play a crucial role in promoting cancer prevention practices. Prevention practices aim to reduce can …
Endometrial Carcinoma of Gastrointestinal-type (EMCG): Incidence, Molecular Features, and Distinction From Other Endometrial Cancers With Gastrointestinal Marker Immunoexpression.
Alzayadneh E, Smith VL, Mills AM. Alzayadneh E, et al. Int J Gynecol Pathol. 2026 Mar 1;45(2):107-119. doi: 10.1097/PGP.0000000000001138. Epub 2025 Oct 7. Int J Gynecol Pathol. 2026. PMID: 41642929
Endometrial carcinoma of gastrointestinal-type (EMCG) is an aggressive endometrial cancer characterized by gastric and/or intestinal-type mucinous morphology, absent/minimal estrogen receptor expression, and at least focal gastrointestinal marker immunoexpression. ...Other …
Endometrial carcinoma of gastrointestinal-type (EMCG) is an aggressive endometrial cancer characterized by gastric and/or intestinal- …
Ultrasensitive detection of colorectal cancer biomarkers in exhaled breath using superhydrophobic HCPs-2Br-based SPME-GC-MS with a two-step pre-enrichment strategy.
Shang H, Wang M, Wang Z, Wang M, Bai L, Yan H. Shang H, et al. Anal Chim Acta. 2026 Mar 1;1389:345099. doi: 10.1016/j.aca.2026.345099. Epub 2026 Jan 15. Anal Chim Acta. 2026. PMID: 41629045
Consequently, there is a pressing need to develop innovative pretreatment technologies to enable the sensitive detection of colorectal cancer (CRC)-related biomarkers for early non-invasive screening. ...It provides a simple, cost-effective, and highly …
Consequently, there is a pressing need to develop innovative pretreatment technologies to enable the sensitive detection of colorecta …
Dancing with KAT6A: Current advances and therapeutic potential in oncology of KAT6A inhibitors.
Xi Z, Wang J, Ge X, Zhang H, Ma Y. Xi Z, et al. Bioorg Chem. 2026 Mar;170:109533. doi: 10.1016/j.bioorg.2026.109533. Epub 2026 Jan 21. Bioorg Chem. 2026. PMID: 41604973 Review.
PF-07248144 has shown antitumor activity in estrogen receptor-positive (ER+) breast cancer models and is currently undergoing clinical evaluation. The development of these inhibitors has been facilitated by structure-based drug design and high-throughput screening, …
PF-07248144 has shown antitumor activity in estrogen receptor-positive (ER+) breast cancer models and is currently undergoing clinica …
Tumor immune organoids in immunotherapy resistance and drug screening.
Zhang M, Li L, Pu H, Wang Y, Zhang X, Guo X, Zhao Y, Meng Q, Yin M. Zhang M, et al. Drug Resist Updat. 2026 Mar;85:101360. doi: 10.1016/j.drup.2026.101360. Epub 2026 Jan 23. Drug Resist Updat. 2026. PMID: 41604831 Review.
Tumor organoids represent a transformative tool in cancer research, as they retain the genetic and phenotypic features of parental tumors and accurately recapitulate their heterogeneity. ...Additionally, we delineate the applications of tumor immune organoids for unravelli …
Tumor organoids represent a transformative tool in cancer research, as they retain the genetic and phenotypic features of parental tu …
Tissue expression of miR-504-5p and miR-429 as diagnostic biomarkers for endometrial cancer and endometrial intraepithelial neoplasia: a pilot study.
Manzi A, De Luca C, Conticelli F, Zizolfi B, Guida M, Troncone G, Di Spiezio Sardo A, De Angelis MC. Manzi A, et al. J Liq Biopsy. 2025 Nov 29;11:100451. doi: 10.1016/j.jlb.2025.100451. eCollection 2026 Mar. J Liq Biopsy. 2025. PMID: 41585943 Free PMC article.
While hysteroscopy with biopsy remains the diagnostic gold standard, the lack of non-invasive biomarkers for early detection and follow-up is a major clinical limitation. MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have emerged as potential …
While hysteroscopy with biopsy remains the diagnostic gold standard, the lack of non-invasive biomarkers for early detection a …
Biomarkers for Gastric Cancer and Premalignant Gastric Conditions.
Yoon JY, Li D, Shah SC. Yoon JY, et al. Gastroenterol Clin North Am. 2026 Mar;55(1):55-72. doi: 10.1016/j.gtc.2025.08.001. Epub 2025 Oct 28. Gastroenterol Clin North Am. 2026. PMID: 41581953 Review.
Gastric cancer (GC) is a major cause of preventable cancer death worldwide. Endoscopic screening is the gold standard for early detection, but due to logistical and cost barriers, organized efforts are limited to select high-incidence countries. …
Gastric cancer (GC) is a major cause of preventable cancer death worldwide. Endoscopic screening is the gold standard f …
Biomarkers for the Diagnosis of Cirrhosis and Cirrhosis-Related Complications.
Hunold T, Govalan R, Parikh N. Hunold T, et al. Gastroenterol Clin North Am. 2026 Mar;55(1):203-216. doi: 10.1016/j.gtc.2025.10.006. Epub 2025 Nov 12. Gastroenterol Clin North Am. 2026. PMID: 41581950 Review.
Cirrhosis is an increasingly prevalent condition, with significant associated morbidity and mortality due to the development of several complications, including portal hypertension and hepatocellular carcinoma (HCC). Early detection of significant liver fibrosis can …
Cirrhosis is an increasingly prevalent condition, with significant associated morbidity and mortality due to the development of several comp …
Biomarkers for Early Detection and Monitoring of Colorectal Cancer.
Char SK, Singh H, Ng K. Char SK, et al. Gastroenterol Clin North Am. 2026 Mar;55(1):143-164. doi: 10.1016/j.gtc.2025.10.002. Epub 2025 Nov 27. Gastroenterol Clin North Am. 2026. PMID: 41581947 Review.
Colorectal cancer (CRC) is a major global health burden. Although colonoscopy remains the gold standard for screening, less invasive biomarker-based stool and blood tests including FIT, multi-target stool DNA/RNA assays, and blood-based biomarker tests are emerging …
Colorectal cancer (CRC) is a major global health burden. Although colonoscopy remains the gold standard for screening, less in …
Biomarkers for Malignant and Nonmalignant Diseases of the Pancreas.
Downie JM, Mills K, Majumder S, Hernandez-Barco YG. Downie JM, et al. Gastroenterol Clin North Am. 2026 Mar;55(1):125-142. doi: 10.1016/j.gtc.2025.10.005. Epub 2025 Nov 25. Gastroenterol Clin North Am. 2026. PMID: 41581946 Review.
We highlight the clinical utility and limitations of existing biomarkers and discuss promising developments in molecular, genetic, and fluid-based diagnostics. Improved biomarkers may enhance early detection and risk stratification strategies for benign and malignan …
We highlight the clinical utility and limitations of existing biomarkers and discuss promising developments in molecular, genetic, and fluid …
Diagnostic and Prognostic Biomarkers for Barrett's Esophagus.
Wang F, Kahn A, Kisiel JB, Iyer PG. Wang F, et al. Gastroenterol Clin North Am. 2026 Mar;55(1):1-19. doi: 10.1016/j.gtc.2025.09.001. Epub 2025 Oct 28. Gastroenterol Clin North Am. 2026. PMID: 41581944 Review.
The increasing burden of esophageal adenocarcinoma (EAC) has driven efforts to improve early detection and risk stratification. Barrett's esophagus (BE), the only known precursor to EAC, presents an opportunity for screening and surveillance. ...Their integra …
The increasing burden of esophageal adenocarcinoma (EAC) has driven efforts to improve early detection and risk stratification …
Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy.
Kennedy AK, Herrera-Rueda MA, Wilby R, Wuest F, LaPointe P. Kennedy AK, et al. Bioorg Chem. 2026 Mar;170:109522. doi: 10.1016/j.bioorg.2026.109522. Epub 2026 Jan 18. Bioorg Chem. 2026. PMID: 41576901 Free article.
Radiotheragnostics is a promising but still developing approach for cancer diagnosis and treatment, limited by the availability of high-affinity, targetable proteins. One such target is the 90 kDa heat shock protein (Hsp90), a chaperone essential for protein folding and st …
Radiotheragnostics is a promising but still developing approach for cancer diagnosis and treatment, limited by the availability of hi …
Design and evaluation of glycyrrhetinic acid-Pt(IV) hybrids for targeted therapy of liver cancer with reduced systemic toxicity.
Shang Y, Hu Z, Fei W, Pang M, Chen B, Zhou T, Shen T. Shang Y, et al. Bioorg Chem. 2026 Mar;170:109513. doi: 10.1016/j.bioorg.2026.109513. Epub 2026 Jan 18. Bioorg Chem. 2026. PMID: 41576899
In this study, a series of platinum-based hybrids incorporating glycyrrhetinic acid (GA) as axial ligands were designed, synthesized, and evaluated for their antitumor activity against various cancer cell lines. The lead complex GABP (glycyrrhetinic acid-carboplatin conjug …
In this study, a series of platinum-based hybrids incorporating glycyrrhetinic acid (GA) as axial ligands were designed, synthesized, and ev …
Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker-driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review).
Jin E, Lin W, Zeng X. Jin E, et al. Oncol Rep. 2026 Mar;55(3):53. doi: 10.3892/or.2026.9058. Epub 2026 Jan 23. Oncol Rep. 2026. PMID: 41574726 Free PMC article. Review.
The management of nasopharyngeal carcinoma (NPC), a malignancy with pronounced geographic prevalence in Southeast Asia, is undergoing a paradigm shift toward precision medicine driven by innovations in early detection and minimally invasive therapy. Breakthroughs in …
The management of nasopharyngeal carcinoma (NPC), a malignancy with pronounced geographic prevalence in Southeast Asia, is undergoing a para …
Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review).
Jiang J, Dong G, Zhang Z, Lei X, Huang F, Li S, Ma J, Bai J, Ge Q, Wei H, Zhao Z. Jiang J, et al. Oncol Rep. 2026 Mar;55(3):49. doi: 10.3892/or.2026.9054. Epub 2026 Jan 23. Oncol Rep. 2026. PMID: 41574717 Free PMC article. Review.
Lung cancer remains a significant global health challenge, with metastatic progression being the leading driver of mortality. Organoid technology provides a tractable, physiologically relevant platform to model key aspects of lung cancer metastasis in vitro. The pre …
Lung cancer remains a significant global health challenge, with metastatic progression being the leading driver of mortality. Organoi …
Novel 5,7-Diazaindole-based ERK5 inhibitor induces endoplasmic reticulum stress and mitochondrial apoptosis in non-small cell lung Cancer.
Tian B, Li Y, Xue P, Chen R, Lv S, He L, Lin G, Xiao J, Long L, Cao G, Guo C, Huang L. Tian B, et al. Bioorg Chem. 2026 Mar;170:109512. doi: 10.1016/j.bioorg.2026.109512. Epub 2026 Jan 16. Bioorg Chem. 2026. PMID: 41570587
The extracellular signal-regulated kinase 5 (ERK5) signaling pathway represents a promising therapeutic target for non-small cell lung cancer (NSCLC), yet the development of potent and selective inhibitors remains a challenge. ...Among them, compound I1 emerged as the most …
The extracellular signal-regulated kinase 5 (ERK5) signaling pathway represents a promising therapeutic target for non-small cell lung ca …
Design, synthesis and biological evaluation of novel isoalantolactone-benzylamine derivatives leading to the discovery of a PARP1 inhibitor with selective cytotoxicity against MCF-7 breast cancer cells.
Cui B, Song Y, Wang X, Wang Y, Chen X, Yu S, Man D, Yuan H, Piao G, Tian Y. Cui B, et al. Bioorg Chem. 2026 Mar;170:109521. doi: 10.1016/j.bioorg.2026.109521. Epub 2026 Jan 19. Bioorg Chem. 2026. PMID: 41570584
Despite significant advances in cancer treatment in recent years, existing therapies still exhibit notable limitations. ...In vitro, compound 3 f exhibited significant dose-dependent anti-cancer activity, inhibiting MCF-7 cancer cell migration, invasion, COL1 …
Despite significant advances in cancer treatment in recent years, existing therapies still exhibit notable limitations. ...In vitro, …
Lometrexol targets MRPL2 to suppress NSCLC via dual regulation of mitochondrial ribosomal activity and nuclear PDCD11/ Ca2+ signaling.
Jin X, Zhang L, Pan K, Ying C, Zhu D. Jin X, et al. Bioorg Chem. 2026 Mar;170:109509. doi: 10.1016/j.bioorg.2026.109509. Epub 2026 Jan 14. Bioorg Chem. 2026. PMID: 41558196
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, necessitating novel therapeutic targets. Recent studies emphasize the significance of mitochondrial ribosomal proteins (MRPs) in cancer, showing altered expression in diff …
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, necessitating novel therapeutic target …
SERS-enabled immune monitoring: Decoding the tumor microenvironment for precision Cancer immunotherapy.
Chen B, Gao J, Sun H, Chen Z, Qiu X. Chen B, et al. Int Immunopharmacol. 2026 Mar 1;172:116241. doi: 10.1016/j.intimp.2026.116241. Epub 2026 Jan 18. Int Immunopharmacol. 2026. PMID: 41554222 Review.
The tumor immune microenvironment (TME) is pivotal in regulating cancer initiation, progression, and therapeutic response. Despite major advances in immunotherapy, clinical outcomes remain limited by low response rates and unpredictable immune-related adverse events (irAEs …
The tumor immune microenvironment (TME) is pivotal in regulating cancer initiation, progression, and therapeutic response. Despite ma …
Breast cancer incidence, by stage at diagnosis, and mortality in 21 European countries in the era of mammography screening: an international population-based study.
Cardoso R, Ola I, Jansen L, Hackl M, Ihle P, Francart J, Van Damme N, Valerianova Z, Atanasov T, Májek O, Ngo O, Innos K, Mägi M, Yonli SD, Woronoff AS, Tretarre B, Poncet F, Katalinic A, Walsh PM, Vincerževskienė I, Steponaviciene L, de Munck L, Siesling S, Johannesen TB, Hofvind S, Calisto R, Bento MJ, Alves da Costa F, Mayer A, Lourenço A, Žagar T, Tomšič S, Rodríguez-Barranco M, Sánchez MJ, Lopez de Munain Marques A, Marcos-Gragera R, Sanvisens A, Gil AS, Chirlaque Lopez MD, Galceran J, Saladié F, Sundquist K, Sundquist J, Persson MÅ, Blum M, Mousavi M, von Moos R, Sumkina O, Ryzhov A, Hoffmeister M, Brenner H. Cardoso R, et al. Lancet Reg Health Eur. 2025 Dec 29;62:101574. doi: 10.1016/j.lanepe.2025.101574. eCollection 2026 Mar. Lancet Reg Health Eur. 2025. PMID: 41552365 Free PMC article.
BACKGROUND: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare ch …
BACKGROUND: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the m …
Ribosome biogenesis is increased in hepatocellular carcinoma and represents a potential therapeutic target.
Geisler SB, Oxe KC, Boukoura S, Dulina E, Larsen DH. Geisler SB, et al. NAR Cancer. 2026 Jan 16;8(1):zcaf058. doi: 10.1093/narcan/zcaf058. eCollection 2026 Mar. NAR Cancer. 2026. PMID: 41551405 Free PMC article.
Globally, liver cancer is the sixth most prevalent cancer type and the third leading cause of cancer-related deaths, making the need for improved treatment evident. ...Our screening identified liver cancer as a potential candidate. Gene expressi …
Globally, liver cancer is the sixth most prevalent cancer type and the third leading cause of cancer-related deaths, ma …
From BERT to GPT-4: A systematic review of AI-Driven toxicity extraction and grading in radiation oncology.
Mastroleo F, Borras-Osorio M, Patel SP, Peterson S, Wilson R, Namazi MJ, Zhou M, Shiraishi S, Foong AYK, Routman DM, Waddle MR. Mastroleo F, et al. Tech Innov Patient Support Radiat Oncol. 2025 Dec 18;37:100372. doi: 10.1016/j.tipsro.2025.100372. eCollection 2026 Mar. Tech Innov Patient Support Radiat Oncol. 2025. PMID: 41550701 Free PMC article.
This systematic review evaluates the current literature on the use of NLP and LLMs to extract toxicity data from radiation oncology records. METHODS: Three databases were systematically searched on 14 March 2025 for English-language studies. ...Multi-center datasets and se …
This systematic review evaluates the current literature on the use of NLP and LLMs to extract toxicity data from radiation oncology r …
Pancreatic cancer mortality and associated productivity losses in Spain: A population-based estimate (2013-2022).
Darbà J, Ascanio M, Rodríguez A. Darbà J, et al. Health Policy. 2026 Mar;165:105564. doi: 10.1016/j.healthpol.2026.105564. Epub 2026 Jan 9. Health Policy. 2026. PMID: 41539169 Free article.
BACKGROUND: Pancreatic cancer remains as the cancer type with the poorest prognosis, characterized by rising incidence and mortality rates. ...CONCLUSIONS: These findings provide valuable insights into the societal costs of pancreatic cancer in Spain. Investm …
BACKGROUND: Pancreatic cancer remains as the cancer type with the poorest prognosis, characterized by rising incidence and mor …
Targeting the phosphoinositide 3-kinase signaling pathway and epidermal growth factor receptor: The potential of dimethylcardamonin-derived amino acids in triple-negative breast cancer therapy.
Chawapun P, Khamto N, Halimi YF, Utama K, Siriphong S, Janthong A, Dechsupa N, Kantapan J, Kungwan N, Rungrotmongkol T, Meepowpan P, Sangthong P. Chawapun P, et al. Bioorg Chem. 2026 Mar;170:109483. doi: 10.1016/j.bioorg.2026.109483. Epub 2026 Jan 7. Bioorg Chem. 2026. PMID: 41539040
Compounds 2h-2j demonstrated most excellent inhibitory effectiveness against breast cancer cells, with IC(50) values of 4.59 0.06, 5.33 0.59, and 6.89 0.85 muM, respectively, in MDA-MB-231 cells. These DMC derivatives not only induced DNA damage but also triggered morpholo …
Compounds 2h-2j demonstrated most excellent inhibitory effectiveness against breast cancer cells, with IC(50) values of 4.59 0.06, 5. …
Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes.
Heer CD, Elia JL, Menon V, Johnson SS, Arbelaez SR, Friedman S, Lopez-Giraldez F, Sundaram RK, Herzon SB, Bindra RS, Gueble SE. Heer CD, et al. NAR Cancer. 2026 Jan 9;8(1):zcaf052. doi: 10.1093/narcan/zcaf052. eCollection 2026 Mar. NAR Cancer. 2026. PMID: 41522810 Free PMC article.
Genetic instability is a hallmark of cancer, often arising from mutations to DNA damage repair and response (DDR) genes. Classical genetic, biochemical, and structural approaches elucidated the foundational mechanisms of DDR pathways and provided a scientific understanding …
Genetic instability is a hallmark of cancer, often arising from mutations to DNA damage repair and response (DDR) genes. Classical ge …
Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenias of Undetermined Significance: 2026 Update on Clinical Associations and Management Recommendations.
Mangaonkar AA, Bolton KL, Patnaik MM. Mangaonkar AA, et al. Am J Hematol. 2026 Mar;101(3):550-565. doi: 10.1002/ajh.70205. Epub 2026 Jan 8. Am J Hematol. 2026. PMID: 41508691 Review.
CH is linked to numerous other diseases including venous thromboembolism, type 2 diabetes mellitus, chronic obstructive pulmonary disease, osteoporosis, and gout, with a potential protective impact in Alzheimer's disease (AD). MANAGEMENT RECOMMENDATIONS: CH detection is be …
CH is linked to numerous other diseases including venous thromboembolism, type 2 diabetes mellitus, chronic obstructive pulmonary disease, o …
Individual patient-reported symptom items discriminate imaging-graded dysphagia in head and neck cancer patients treated with radiotherapy: secondary analysis of pooled prospective studies.
Manduchi B, Jefferson TC, Moreno AC, Barbon CEA, Whisenant M, Martino R, Fuller CD, Hutcheson KA; OPC-SURVIVOR Research Program. Manduchi B, et al. Radiother Oncol. 2026 Mar;216:111365. doi: 10.1016/j.radonc.2026.111365. Epub 2026 Jan 6. Radiother Oncol. 2026. PMID: 41506576

RESULTS: Among 264 patients (mean age 62; 87 % male; 47 % nasopharyngeal cancer; 55 % post-RT), -Swallow 6 was associated with D 1 and D 2 (RRs = 1.8-2.6, p < 0.05), showing high SP (92-95 %) but low SN (23-30 %). ...While 6 may flag moderate-severe impairment, lower th

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RESULTS: Among 264 patients (mean age 62; 87 % male; 47 % nasopharyngeal cancer; 55 % post-RT), -Swallow 6 was associated with D 1 an …
Integrated QSAR, molecular docking, and dynamics-based discovery of a potent selective HDAC1 inhibitor with therapeutic potential in aggressive cancers.
Shelke S, Jawarkar RD, Khatale PN, Shah U, Alzahrani AYA, Samad A, Al-Hussain SA, Al-Mutairi AA, Zaki MEA. Shelke S, et al. J Mol Graph Model. 2026 Mar;143:109271. doi: 10.1016/j.jmgm.2025.109271. Epub 2026 Jan 3. J Mol Graph Model. 2026. PMID: 41506199
Validation through in vitro methods using the MTT assay on MDA-MB-231 (triple-negative breast cancer) and A431 (epidermoid carcinoma) cell lines revealed significant, dose-dependent cytotoxic effects, with IC(50) values of 2.7 muM and 91.6 nM, respectively. ...By combining …
Validation through in vitro methods using the MTT assay on MDA-MB-231 (triple-negative breast cancer) and A431 (epidermoid carcinoma) …
A Phenstatin-based indole-chalcone hybrid as novel anti-inflammatory agent targeting the NLRP3 Inflammasome: Leads from computational and preclinical studies.
Meher RK, Maharana J, Kovvuri J, Kumar KN, Pradhan T, Kailaje V, Ingle A, Sen S, Barkume M, Patkar M, Vaibhaw A, Mir SA, Ghosh A, Kamte S, Kamal A, Kode J. Meher RK, et al. Bioorg Chem. 2026 Mar;170:109429. doi: 10.1016/j.bioorg.2025.109429. Epub 2025 Dec 26. Bioorg Chem. 2026. PMID: 41500010
We previously identified and characterized 9a, a phenstatin-based indole-chalcone hybrid exhibiting potent anti-oral cancer activity. This study was aimed at understanding the mechanistic role of hybrid 9a in regulating the NLRP3 inflammasome pathway, using an array of com …
We previously identified and characterized 9a, a phenstatin-based indole-chalcone hybrid exhibiting potent anti-oral cancer activity. …
Sleep quality and its determinants among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia: A multicenter cross-sectional study.
Tamene FB, Mihiretie EA, Zeleke TK, Tarekegn GY, Moges TA, Desalew AF, Sendekie AK, Wondm SA. Tamene FB, et al. J Psychosom Res. 2026 Mar;202:112515. doi: 10.1016/j.jpsychores.2025.112515. Epub 2026 Jan 3. J Psychosom Res. 2026. PMID: 41494505 Free article.
OBJECTIVE: Sleep quality plays a crucial role in overall well-being, and many caregivers of cancer patients report being dissatisfied with their sleep. The aim of this study was to assess sleep quality and its determinants among caregivers of patients with cancer at …
OBJECTIVE: Sleep quality plays a crucial role in overall well-being, and many caregivers of cancer patients report being dissatisfied …
Combined in silico and in vitro cytotoxic profiling of novel quinazoline derivatives targeting anaplastic lymphoma kinase for lung cancer therapy.
Saravanakumar N, Poorani ASA, Santhoshkumar P, Dhanabalan AK, Gayathri S, Ashokkumar B, Srikanth S, Ulaganathan V, Suresh P. Saravanakumar N, et al. Bioorg Chem. 2026 Mar;170:109450. doi: 10.1016/j.bioorg.2025.109450. Epub 2025 Dec 29. Bioorg Chem. 2026. PMID: 41494474
Lung cancer is one of the most common cancers globally, and targeting specific molecular pathways, such as the anaplastic lymphoma kinase (ALK), has shown great potential in developing effective treatments. ...In particular, compound 8c, featuring a 4-methoxybenzene moiety …
Lung cancer is one of the most common cancers globally, and targeting specific molecular pathways, such as the anaplastic lymphoma ki …
Artificial Intelligence for Genetic Cancer Risk Assessment in Gynecologic Oncology: A Review of the Current Landscape and Future Directions.
Haghighat R, Levi SR, Frey MK. Haghighat R, et al. Clin Obstet Gynecol. 2026 Mar 1;69(1):36-44. doi: 10.1097/GRF.0000000000000996. Epub 2026 Jan 6. Clin Obstet Gynecol. 2026. PMID: 41492947 Review.
Hereditary cancer syndromes are associated with up to 25% of ovarian and 5% of endometrial cancers, yet rates of genetic testing and counseling remain low. ...We highlight key challenges, including data bias, privacy, and implementation barriers, and outline future directi …
Hereditary cancer syndromes are associated with up to 25% of ovarian and 5% of endometrial cancers, yet rates of genetic testing and …
Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation.
Li Y, Li C, Wang Y, Zhou J, Zhou B, Mei L, Niu H, Hu Z, Tian J, Li C. Li Y, et al. Cancer Lett. 2026 Mar 1;640:218241. doi: 10.1016/j.canlet.2026.218241. Epub 2026 Jan 3. Cancer Lett. 2026. PMID: 41490754
Precise localization and complete resection are critical for preventing recurrence in non-small cell lung cancer (NSCLC), yet these goals remain clinically challenging. The second near-infrared window (1000-1700 nm, NIR-II) fluorescent molecular imaging offers a promising …
Precise localization and complete resection are critical for preventing recurrence in non-small cell lung cancer (NSCLC), yet these g …
Design, synthesis, and biological evaluation of novel steroidal selenosemicarbazone derivatives as potent antitumor agents.
Gan C, Gan B, Li Y, Huang Y, Liu Z, Gu Y, Chen H, Lin Q. Gan C, et al. J Steroid Biochem Mol Biol. 2026 Mar;257:106931. doi: 10.1016/j.jsbmb.2025.106931. Epub 2025 Dec 31. J Steroid Biochem Mol Biol. 2026. PMID: 41482078
The development of novel chemotherapeutic agents with high efficacy and low toxicity remains a critical challenge in oncology. In this study, a novel series of steroidal selenosemicarbazone derivatives were designed and synthesized through the selenium functionalization of …
The development of novel chemotherapeutic agents with high efficacy and low toxicity remains a critical challenge in oncology. In thi …
Epidemiology of human papillomavirus strains in Southern Nigeria: A cross-sectional analysis.
Onwuamah CK, Vincent GD, Amoo AE, Okwuzu J, Adesina M, Ogbu CA, Ore T, Uwandu M, Ahmed RA, Abimbola BS, Idigbe I, Okonkwo N, Sokei J, Okoli CL, Ezemelue PN, Ajigbewu OH, Shaibu JO, Abifarin K, Ohihoin GA, Nzeribe E, David A, Tucker DJ, Flowers L, Iwelunmor J, Ofotokun I, Ezechi OC. Onwuamah CK, et al. Diagn Microbiol Infect Dis. 2026 Mar;114(3):117240. doi: 10.1016/j.diagmicrobio.2025.117240. Epub 2025 Dec 24. Diagn Microbiol Infect Dis. 2026. PMID: 41475073
BACKGROUND: Human Papillomavirus (HPV) 16 and HPV18 strains cause approximately 70% of all cervical cancer cases. Understanding the predominant strains is critical for HPV vaccination programmes. ...Further studies are needed to evaluate their oncogenic association, guide …
BACKGROUND: Human Papillomavirus (HPV) 16 and HPV18 strains cause approximately 70% of all cervical cancer cases. Understanding the p …
Biopsy for Suspicious Oral Lesions: A Review From the American Head and Neck Society-Cancer Prevention Service.
Gates JC, Edwards H, Villa A, Purdy N, Troka M, Varela P, Self Q, Liu Y, Dundar Y, Brooks PJ, Adilbay D, Birkeland A, Cramer J. Gates JC, et al. Head Neck. 2026 Mar;48(3):884-892. doi: 10.1002/hed.70148. Epub 2025 Dec 30. Head Neck. 2026. PMID: 41466514 Review.
BACKGROUND: Oral cancer is often preceded by a precursor lesion. This presents an opportunity for early diagnosis and intervention. ...AI has shown encouraging results in both automated detection of dysplasia and prediction of malignant progression, achieving …
BACKGROUND: Oral cancer is often preceded by a precursor lesion. This presents an opportunity for early diagnosis and interven …
Integrating multi-omics and artificial intelligence fuels advanced target identification and drug discovery.
Chen H, Shi Y, Yuan M, Li H, Liu X. Chen H, et al. Biotechnol Adv. 2026 Mar-Apr;87:108785. doi: 10.1016/j.biotechadv.2025.108785. Epub 2025 Dec 27. Biotechnol Adv. 2026. PMID: 41461245 Review.
Target identification is pivotal for developing novel therapeutics in cancer and other diseases. Traditional experiment screening methods are constrained by low throughput and the complexity of biological systems. ...
Target identification is pivotal for developing novel therapeutics in cancer and other diseases. Traditional experiment screening …
Practical aspects of managing multimorbidity in older adults with cancer.
O'Hanlon S, Baxter M, Liposits G. O'Hanlon S, et al. Curr Opin Support Palliat Care. 2026 Mar 1;20(1):5-10. doi: 10.1097/SPC.0000000000000790. Epub 2026 Jan 27. Curr Opin Support Palliat Care. 2026. PMID: 41460166 Review.
PURPOSE OF REVIEW: Managing multimorbidity in older adults with cancer is a central, complex challenge in modern oncology. Historically, this population was underrepresented in clinical trials, leaving clinicians without practical guidance. ...SUMMARY: Recent eviden …
PURPOSE OF REVIEW: Managing multimorbidity in older adults with cancer is a central, complex challenge in modern oncology. His …
Comparing FACIT-fatigue and EORTC QLQ-FA12 for assessing the quality of life in people with cancer-related fatigue.
Zhang B, Randhawa A, Patel A, Bruera E, Hart NH, Bottomley A, Cella D, Al-Khaifi M, Patel P, Chow E, Wong HCY. Zhang B, et al. Curr Opin Support Palliat Care. 2026 Mar 1;20(1):52-61. doi: 10.1097/SPC.0000000000000791. Epub 2026 Jan 27. Curr Opin Support Palliat Care. 2026. PMID: 41460165
PURPOSE OF REVIEW: Two common quality of life (QoL) questionnaires for cancer-related fatigue (CRF) are the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Fatigue 12 (QLQ-FA12) and Functional Assessment of Chronic Il …
PURPOSE OF REVIEW: Two common quality of life (QoL) questionnaires for cancer-related fatigue (CRF) are the European Organisation for …
Clinical Decision Support Systems for cancer symptom management: A scoping review.
Chi J, Zhong C, Tang J, Guo B, Zhang Y, Deng S, Guo Z, Wu Y. Chi J, et al. Int J Nurs Stud. 2026 Mar;175:105317. doi: 10.1016/j.ijnurstu.2025.105317. Epub 2025 Dec 16. Int J Nurs Stud. 2026. PMID: 41442839 Review.
The functions were mainly concentrated on the combination of intelligent monitoring and early warning with personalized management and clinical optimization (38.2 %), followed by systems focusing solely on intelligent monitoring and early warning (34.1 %). Multiple …
The functions were mainly concentrated on the combination of intelligent monitoring and early warning with personalized management an …
Pharmacoinformatic discovery of plant-derived BRD4 inhibitors as potential therapeutic agents for leukemia.
Lalu AC, Joseph BB, Varun TK, Thaikkad A, Dcunha L, Raju R, Jayanandan A. Lalu AC, et al. J Mol Graph Model. 2026 Mar;143:109262. doi: 10.1016/j.jmgm.2025.109262. Epub 2025 Dec 18. J Mol Graph Model. 2026. PMID: 41442825
Leukemia is a type of blood cancer that occurs when abnormal white blood cells grow too quickly. This uncontrolled growth begins in the bone marrow, where blood cells are produced. Leukemia remains a major health concern due to its high incidence and difficult prognosis. I …
Leukemia is a type of blood cancer that occurs when abnormal white blood cells grow too quickly. This uncontrolled growth begins in t …
Novel 2-mercaptoquinazolinone N-hydroxycinnamamides as histone deacetylase inhibitors: design, synthesis, and anticancer evaluation.
Thao LT, Kim HK, Ngan NP, Cuong BQ, Oanh DTK, Dung DTM, Kang DH, Kim HY, Song EH, Kang JS, Anh DT, Tung TT, Han SB, Nam NH. Thao LT, et al. Bioorg Med Chem Lett. 2026 Mar;132:130509. doi: 10.1016/j.bmcl.2025.130509. Epub 2025 Dec 18. Bioorg Med Chem Lett. 2026. PMID: 41421683
Histone deacetylases (HDACs) are key therapeutic targets in oncology, and hydroxamic acid derivatives represent one of the most effective inhibitor classes. ...Cytotoxicity assays across colorectal (SW620, HCT116), breast (MDA-MB-231), prostate (PC-3), and lung (A549) c …
Histone deacetylases (HDACs) are key therapeutic targets in oncology, and hydroxamic acid derivatives represent one of the most effec …
Tissue Proteomics of Feline Mammary Carcinoma: Differences in Protein Profiles Among Histological Grades Using Liquid Chromatography-Tandem Mass Spectrometry.
Aruvornlop P, Ploypetch S, Sakcamduang W, Sirivisoot S, Kasantikul T, Roytrakul S, Phaonakrop N, Arya N. Aruvornlop P, et al. Vet Comp Oncol. 2026 Mar;24(1):128-139. doi: 10.1111/vco.70033. Epub 2025 Dec 19. Vet Comp Oncol. 2026. PMID: 41420294 Free PMC article.
Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and …
Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mam …
Mental health, coping and related risk factors during the first 2 years of the COVID-19 pandemic in children: Nationally representative, multi-wave, cross-sectional results from 12 countries from the global COH-FIT study.
Agorastos A, Thompson T, Solmi M, Cortese S, Estradé A, Radua J, Dragioti E, Vancampfort D, Thygesen LC, Aschauer H, Schlögelhofer M, Aschauer E, Schneeberger A, Huber CG, Hasler G, Conus P, Do Cuénod KQ, von Känel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca PM, Krebs MO, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Żydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kamiński K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su KP, Kwon JS, Kim M, Lee T, Papsuev O, Manková D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl KG, Domschke K, Bauer M, Koutsouleris N, Winter SM, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas VP, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni AR, Costardi CG, Schuch FB, Polanczyk G, Luiz JM, Fonseca L, Aparicio LV, Valvassori SS, Nordentoft M, Vendsborg P, Hoffmann SH, Sehli J, Sartorius N, Heuss SC, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu… See abstract for full author list ➔ Agorastos A, et al. Eur Neuropsychopharmacol. 2026 Mar;104:112741. doi: 10.1016/j.euroneuro.2025.112741. Epub 2025 Dec 18. Eur Neuropsychopharmacol. 2026. PMID: 41418519 Free article.

Both score changes were significantly but minimally associated to COVID-19 deaths/stringency index. The proportion of children screening positive for depression increased from 3.9 % to 8.3 % (chi2=145.70, p < 0.001) and for major depression from 0.6 % to 2.2 % (chi2=68.

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Both score changes were significantly but minimally associated to COVID-19 deaths/stringency index. The proportion of children screening …
Novel PROTACs with polyhedral alkanes as linkers for enhanced ALK degradation in drug-resistant NSCLC.
Chu D, Han H, Wei C, Zhang X, Yan H, Wang J. Chu D, et al. Bioorg Med Chem. 2026 Mar;134:118521. doi: 10.1016/j.bmc.2025.118521. Epub 2025 Dec 16. Bioorg Med Chem. 2026. PMID: 41418414
The challenge of overcoming drug-resistant mutations in Anaplastic Lymphoma Kinase (ALK), a critical driver of non-small cell lung cancer (NSCLC), remains a pressing clinical concern. This study introduces a novel approach by using polyhedral alkanes as linkers in PROTAC ( …
The challenge of overcoming drug-resistant mutations in Anaplastic Lymphoma Kinase (ALK), a critical driver of non-small cell lung cancer …
Polydimethylsiloxane micropatterning-aided multi-size biomimetic tumor spheroid-on-a-chip for investigating chemotherapy and photodynamic therapy.
Sun M, Zhang J, Zhang F, Deng Z, Xuanyuan T, Liu X, Yu D, Liu W. Sun M, et al. Colloids Surf B Biointerfaces. 2026 Mar;259:115376. doi: 10.1016/j.colsurfb.2025.115376. Epub 2025 Dec 15. Colloids Surf B Biointerfaces. 2026. PMID: 41406679
Three-dimensional (3D) tumor spheroids are increasingly recognized as promising and prospective models for in vitro cancer research and preclinical screening. However, it remains an unmet need for facile construction of a micro-platform to synchronously produce sphe …
Three-dimensional (3D) tumor spheroids are increasingly recognized as promising and prospective models for in vitro cancer research a …
Glucose tolerance and mortality across 24 cancer types and stages: A K-CURE Nationwide registry study.
Sung KH, Yu J, Kim S, Kim MK, Park YM, Han K, Lee SH. Sung KH, et al. Diabetes Obes Metab. 2026 Mar;28(3):2051-2060. doi: 10.1111/dom.70388. Epub 2025 Dec 17. Diabetes Obes Metab. 2026. PMID: 41403262
AIM: To evaluate the association between baseline glycemic status and mortality among patients with cancer and to examine whether these associations differ by stage and cancer type. MATERIALS AND METHODS: We performed a nationwide cohort study using the Korean Ca …
AIM: To evaluate the association between baseline glycemic status and mortality among patients with cancer and to examine whether the …
The Use of First-Void Urine to Screen Women Aged 60-79 for HPV in the UK: The Catch-Up Screen Study.
Rake C, Davidson EJ, Young A, Maskell A, Davies JC, Flynn M, Vidali S, Mohy-Eldin H, Cao J, Nedjai B, Macleod U, Peto J, Gilham C. Rake C, et al. BJOG. 2026 Mar;133(4):814-822. doi: 10.1111/1471-0528.70115. Epub 2025 Dec 15. BJOG. 2026. PMID: 41397685 Free PMC article. Clinical Trial.
OBJECTIVE: Almost half the deaths from cervical cancer in the UK are among women aged over 65 who were already above the upper age of screening when primary HPV screening was introduced in the UK in 2019. ...MAIN OUTCOME MEASURES: Uptake of at-home urine s …
OBJECTIVE: Almost half the deaths from cervical cancer in the UK are among women aged over 65 who were already above the upper age of …
tRF-Ser-TGA-011 impedes gastric cancer progression by targeting the MAP3K13/JNK signaling cascade.
Ma Y, Lu H, Zhang L, Zhang Y, Shen J, Xu W, Zhang Y, Yan F. Ma Y, et al. Cell Signal. 2026 Mar;139:112323. doi: 10.1016/j.cellsig.2025.112323. Epub 2025 Dec 13. Cell Signal. 2026. PMID: 41391674
BACKGROUND: Early-stage gastric cancer (GC) is often asymptomatic, leading to frequent late-stage diagnoses. There is a critical need for non-invasive biomarkers to improve early detection and preoperative risk assessment. Although tRNA-derived fragmen …
BACKGROUND: Early-stage gastric cancer (GC) is often asymptomatic, leading to frequent late-stage diagnoses. There is a critic …
A H2O2-self-supplying and oxygen-evolving nanosystem for amplified chemodynamic therapy of breast cancer.
Wu Y, Li L, Jia L, Wang M, Li W, Ma Y, Wang X, Liu C. Wu Y, et al. Colloids Surf B Biointerfaces. 2026 Mar;259:115363. doi: 10.1016/j.colsurfb.2025.115363. Epub 2025 Dec 11. Colloids Surf B Biointerfaces. 2026. PMID: 41391242
Breast cancer continues to be a prevalent malignancy with high incidence and mortality rates worldwide, urgently calling for more effective treatment options. Chemodynamic therapy (CDT) has gained attention as a novel cancer treatment modality; however, its therapeu …
Breast cancer continues to be a prevalent malignancy with high incidence and mortality rates worldwide, urgently calling for more eff …
A functionally relevant model for interrogating brain tumor-endothelial cell interactions.
Grewal A, Martell E, Kuzmychova H, Chawla U, Jain C, Ramnauth K, Sharif T. Grewal A, et al. J Neurosci Methods. 2026 Mar;427:110657. doi: 10.1016/j.jneumeth.2025.110657. Epub 2025 Dec 11. J Neurosci Methods. 2026. PMID: 41389895 Free article.
NEW METHOD: To achieve this, we developed and validated optimal in vitro culture conditions to support the co-culture of human Group 3 medulloblastoma (G3 MB) cells and microvascular brain endothelial cells (BECs) as an ideal screening model for mechanistic and interventio …
NEW METHOD: To achieve this, we developed and validated optimal in vitro culture conditions to support the co-culture of human Group 3 medul …
A cyclometalated iridium(III) complex with 2-acetylpyridine-N(4)-ortho-chlorophenyl thiosemicarbazone: Potent antiproliferative and antibacterial activities.
Paes BV, Costa DN, Esarev IV, Boschuk S, Lippmann P, Sant'Anna Maranhão S, Pessoa C, Ott I, Beraldo H. Paes BV, et al. J Inorg Biochem. 2026 Mar;276:113179. doi: 10.1016/j.jinorgbio.2025.113179. Epub 2025 Dec 5. J Inorg Biochem. 2026. PMID: 41386042
The Ir(III) complex and H2Ac4oClPh exhibited cytotoxic effects against A549 lung and PC3 prostate cancer cells, with IC(50) values below 5 muM. Although the Ir(III) complex showed a higher IC(50) value against PC3 prostate cancer cells than H2Ac4oClPh, it exhibited …
The Ir(III) complex and H2Ac4oClPh exhibited cytotoxic effects against A549 lung and PC3 prostate cancer cells, with IC(50) values be …
Development of a europium-salicylic acid based nano-biosensor for early detection of GPC3 in DEN-induced hepatocellular carcinoma.
Hassan YM, El-Tantawi H, El-Husseini DM, Ali IR, Attia MS. Hassan YM, et al. Biosens Bioelectron. 2026 Mar 1;295:118281. doi: 10.1016/j.bios.2025.118281. Epub 2025 Dec 5. Biosens Bioelectron. 2026. PMID: 41380232
The early diagnosis of hepatocellular carcinoma (HCC) is hindered by a lack of highly sensitive and specific biomarkers. ...These results establish the Eu-SA thin-film biosensor as a sensitive, selective, and affordable tool for GPC3 detection, holding strong potent …
The early diagnosis of hepatocellular carcinoma (HCC) is hindered by a lack of highly sensitive and specific biomarkers. ...These res …
Apatinib triggers ferroptosis in gastric cancer via HDAC1/HIF1alpha/CA9 signaling axis.
Meng L, Cao L, Lu Y, Yang L, Zhu W. Meng L, et al. Anticancer Drugs. 2026 Mar 1;37(3):169-180. doi: 10.1097/CAD.0000000000001776. Epub 2025 Nov 20. Anticancer Drugs. 2026. PMID: 41372108
Gastric cancer (GC) poses significant therapeutic challenges due to frequent late-stage diagnosis and limited treatment efficacy. ...Integrated computational target prediction (SwissTargetPrediction) and ferroptosis suppressor gene screening (FerrDb) identified carb …
Gastric cancer (GC) poses significant therapeutic challenges due to frequent late-stage diagnosis and limited treatment efficacy. ... …
Transforming Gynecologic Cancer Care Through Artificial Intelligence: A Clinician's Guide to the Evolving Landscape.
Polio A, Wagner VM. Polio A, et al. Clin Obstet Gynecol. 2026 Mar 1;69(1):18-25. doi: 10.1097/GRF.0000000000000985. Epub 2025 Dec 9. Clin Obstet Gynecol. 2026. PMID: 41363042 Review.
Artificial intelligence (AI) is rapidly reshaping gynecologic oncology across the continuum of care. This clinician-focused review synthesizes current evidence for AI-enabled prevention and screening (HPV-informed risk models, AI-assisted colposcopy), early …
Artificial intelligence (AI) is rapidly reshaping gynecologic oncology across the continuum of care. This clinician-focused review sy …
Pubertal Assessment and Growth in Patients With Hemoglobinopathies: A Longitudinal Multicenter Study on the Association With Ferritin Levels.
Dülberg J, Sanchez C, Burckhardt MA, Alacán Friedrich L, Salow V, Radauer-Plank A, Borgmann-Staudt A, Cario H, Diepold M, Drexler B, Infanti L, Kroiss S, Dietliker N, Merki R, Njue L, Oevermann L, Rovó A, Scheinemann K, Schneider M, Balcerek M, Diesch-Furlanetto T. Dülberg J, et al. Eur J Haematol. 2026 Mar;116(3):276-289. doi: 10.1111/ejh.70075. Epub 2025 Dec 7. Eur J Haematol. 2026. PMID: 41354636 Free PMC article.
CONCLUSIONS: Our Results Indicated the Need for Comprehensive Pubertal Screening and Underscored the Importance of Robust Endocrine Follow-Up Care in Individuals With Hemoglobinopathies....
CONCLUSIONS: Our Results Indicated the Need for Comprehensive Pubertal Screening and Underscored the Importance of Robust Endocrine F …
An updated comprehensive review on phytochemical Crinum L. genus alkaloids (2013-2025): Unlocking their anticancer potential.
Alex MGA, El Hawary SS, Melek FR, El Senousy AS, Bassam SM, Mohyeldin MM. Alex MGA, et al. Phytochemistry. 2026 Mar;243:114742. doi: 10.1016/j.phytochem.2025.114742. Epub 2025 Dec 5. Phytochemistry. 2026. PMID: 41354258 Review.
These organs are rich in lycorine-, crinine-, and galantamine-type alkaloids, which exhibit potent cytotoxicity against various cancer cell lines. However, only 35 out of 130 Crinum L. species have undergone phytochemical investigation, presenting a considerable research g …
These organs are rich in lycorine-, crinine-, and galantamine-type alkaloids, which exhibit potent cytotoxicity against various cancer …
Reported mouth self-examination methods for oral cancer screening: a systematic review.
Kadooka MMC, Pedroso CM, Sousa-Neto SS, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB. Kadooka MMC, et al. Oral Surg Oral Med Oral Pathol Oral Radiol. 2026 Mar;141(3):351-356. doi: 10.1016/j.oooo.2025.10.014. Epub 2025 Nov 4. Oral Surg Oral Med Oral Pathol Oral Radiol. 2026. PMID: 41352997
OBJECTIVE: This systematic review aimed to identify and describe the methods of mouth self-examination (MSE) used for oral cancer screening. STUDY DESIGN: A comprehensive search was conducted in six databases (PubMed, EMBASE, Scopus, LILACS, Web of Science, Cochrane …
OBJECTIVE: This systematic review aimed to identify and describe the methods of mouth self-examination (MSE) used for oral cancer …
Implementing decision aid use and shared-decision making in breast cancer screening: A scoping review.
Alkhaldi R, Pathak N, Mintsopoulos V, Fazelzad R, Schrager S, Villain P, Ivers N, Nadler MB. Alkhaldi R, et al. Patient Educ Couns. 2026 Mar;144:109443. doi: 10.1016/j.pec.2025.109443. Epub 2025 Dec 2. Patient Educ Couns. 2026. PMID: 41352313
OBJECTIVES: International guidelines vary regarding the age range for mammography screening for women at average breast cancer risk; however, all note the importance of shared-decision making (SDM). ...INCLUSION CRITERIA: studies targeting providers and/or women at …
OBJECTIVES: International guidelines vary regarding the age range for mammography screening for women at average breast cancer …
An ultrasensitive miRNA-25 aptasensor based on Co@CNTs nanoaggregates for early detection of pancreatic cancer.
Han Y, Zhou M, Zhu M, Zhang W, Liu Y, Liu T, Chu Z, Jin W. Han Y, et al. Biosens Bioelectron. 2026 Mar 1;295:118288. doi: 10.1016/j.bios.2025.118288. Epub 2025 Dec 1. Biosens Bioelectron. 2026. PMID: 41352058
miRNA-25 is a critical and specific biomarker for the early diagnosis of pancreatic cancer. However, its sensitive and efficient detection remains challenging due to its extremely low abundance and time-consuming procedures of conventional methods. ...This CC …
miRNA-25 is a critical and specific biomarker for the early diagnosis of pancreatic cancer. However, its sensitive and efficie …
Clinical Outcomes and Risk Implications of HPV 31 Infection: A 10-Year Retrospective Cohort Study.
Ozdemir CY, Marangoz B, Ozdemir N, Cicekli N, Abacı B, Arioz DT. Ozdemir CY, et al. Diagn Cytopathol. 2026 Mar;54(3):167-172. doi: 10.1002/dc.70061. Epub 2025 Dec 4. Diagn Cytopathol. 2026. PMID: 41346095
OBJECTIVE: To describe the long-term clinical outcomes of women diagnosed with human papillomavirus type 31 (HPV 31) infection and to assess its potential implications for genotype-specific cervical cancer risk stratification in a real-world screening setting. METHO …
OBJECTIVE: To describe the long-term clinical outcomes of women diagnosed with human papillomavirus type 31 (HPV 31) infection and to assess …
Multi-centre clinical validation of the NeuMoDx HPV assay for ASC-US / LSIL triage.
Chin T, Oštrbenk A, Verhavert N, Poljak M, Padalko E. Chin T, et al. Diagn Microbiol Infect Dis. 2026 Mar;114(3):117208. doi: 10.1016/j.diagmicrobio.2025.117208. Epub 2025 Nov 26. Diagn Microbiol Infect Dis. 2026. PMID: 41343893
Although it has been validated for primary HPV-based cervical cancer screening, its performance in the triage of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL) in cytology-based screening algo …
Although it has been validated for primary HPV-based cervical cancer screening, its performance in the triage of atypical squa …
Self-confined catalytic DNA circuit for on-site nonenzymatic amplified microRNA imaging.
Hu X, Xie M, Lang Y, Zhang J, He L, Jiang X, Zou H, Zhang Z, Li S. Hu X, et al. Biosens Bioelectron. 2026 Mar 1;295:118265. doi: 10.1016/j.bios.2025.118265. Epub 2025 Nov 25. Biosens Bioelectron. 2026. PMID: 41330304
MicroRNAs (miRNAs) are critical regulators in cancer biology, yet their low abundance and high sequence similarity pose significant challenges for accurate intracellular detection. ...This work highlights a generalizable self-confined, nonenzymatic nucleic acid ampl …
MicroRNAs (miRNAs) are critical regulators in cancer biology, yet their low abundance and high sequence similarity pose significant c …
Split proximity circuit initiated CRISPR-Cas12a system profiling exosomal surface proteins for early cancer detection.
Xu W, Lin Y, Huang Z, Li Y, Lu Y, Liu M, Cui S, Zhang T, Shi N, Sheng Y, Hu J. Xu W, et al. Biosens Bioelectron. 2026 Mar 1;295:118280. doi: 10.1016/j.bios.2025.118280. Epub 2025 Dec 1. Biosens Bioelectron. 2026. PMID: 41330302
Early diagnosis of breast cancer is critical for improving prognosis, but traditional methods have limitations. ...The combination of high sensitivity, minimal sample requirements, and an exosome isolation-free workflow positions the SPC-CRISPR system as a promising …
Early diagnosis of breast cancer is critical for improving prognosis, but traditional methods have limitations. ...The combina …
A Comparative Study of the Global Burden of Prostate Cancer (1990-2021): Emphasis on the Disparities Between the United States and China.
Li J, Wu Y, Hou J, Liu H, Wang Y, Zhang F, Gu P, Liu X. Li J, et al. Prostate. 2026 Mar;86(4):451-463. doi: 10.1002/pros.70104. Epub 2025 Dec 2. Prostate. 2026. PMID: 41329033
CONCLUSION: The PCa burden in the US and China has evolved in markedly different directions over the past three decades, reflecting profound impact in screening strategies and population aging. High SDI countries should refine risk-based screening protocols and mana …
CONCLUSION: The PCa burden in the US and China has evolved in markedly different directions over the past three decades, reflecting profound …
Design, synthesis, and activity evaluation of alpinetin derivatives as potential anti-liver cancer drugs.
Yi Y, Sun Y, Zhang X, Xin J, Zhao F, Zhu W, Liu S. Yi Y, et al. Bioorg Med Chem Lett. 2026 Mar;132:130482. doi: 10.1016/j.bmcl.2025.130482. Epub 2025 Nov 27. Bioorg Med Chem Lett. 2026. PMID: 41317750
Liver cancer represents a major global health challenge, significantly impacting populations both in China and worldwide. ...Therefore, this study suggests that ALP and its derivatives may become promising drugs for exerting anti liver cancer effects by regulating t …
Liver cancer represents a major global health challenge, significantly impacting populations both in China and worldwide. ...Therefor …
A biodegradable nanomedicine for potentiated cancer therapy via Ca(2+)-overload and photothermal dual-amplifying cuproptosis.
Wang L, Deng Y, Zhou X, Song K, Jiang C, Zhao F, Li X. Wang L, et al. J Colloid Interface Sci. 2026 Mar;705:139548. doi: 10.1016/j.jcis.2025.139548. Epub 2025 Nov 23. J Colloid Interface Sci. 2026. PMID: 41308482
Cuproptosis holds promise for breast cancer therapy, yet systemic copper delivery risks off-target toxicity, and intrinsic tumor resistance mechanisms limit its therapeutic efficacy. ...This work presents a safe and efficient nanoplatform for cuproptosis potentiation, prov …
Cuproptosis holds promise for breast cancer therapy, yet systemic copper delivery risks off-target toxicity, and intrinsic tumor resi …
Overall Good Quality of Life Reported by Survivors of Childhood Hodgkin Lymphoma in Sweden and Finland.
Giertz M, Englund A, Fernsten F, Michelsen Wilk S, Niinimäki R, Harila A, Aarnivala H. Giertz M, et al. Acta Paediatr. 2026 Mar;115(3):697-705. doi: 10.1111/apa.70386. Epub 2025 Nov 27. Acta Paediatr. 2026. PMID: 41307354 Free PMC article.
The EQ-VAS may serve as a useful, simple screening tool for detecting survivors in need of psychosocial interventions....
The EQ-VAS may serve as a useful, simple screening tool for detecting survivors in need of psychosocial interventions....
Elective Neck Dissection in Advanced Cutaneous Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.
Key S, Kwok M, McLean T. Key S, et al. Clin Otolaryngol. 2026 Mar;51(2):203-212. doi: 10.1111/coa.70063. Epub 2025 Nov 26. Clin Otolaryngol. 2026. PMID: 41298120 Review.
RESULTS: Of 983 unique studies, 119 studies underwent full-text screening. Six studies underwent systematic review and meta-analysis. Of 522 included patients, 197 (37.7%) underwent END and 325 (62.3%) underwent observation. ...
RESULTS: Of 983 unique studies, 119 studies underwent full-text screening. Six studies underwent systematic review and meta-analysis. …
Rethinking Gleason pattern quantification in predicting metastasis: results of 20 years of follow-up in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer.
Kroon LJ, Remmers S, de Vos II, Kweldam CF, Rijstenberg LL, van den Bergh RCN, Roobol MJ, van Leenders GJLH. Kroon LJ, et al. Histopathology. 2026 Mar;88(4):881-888. doi: 10.1111/his.70052. Epub 2025 Nov 26. Histopathology. 2026. PMID: 41293883 Clinical Trial.
INTRODUCTION: The Gleason grading system for prostate cancer (PCa) is based on the proportions of Gleason patterns (GP) 3-5. While pure GP3 has minimal metastatic potential, it is unclear whether GP3 quantity in the presence of GP4 and GP5 affects oncological outcomes. ... …
INTRODUCTION: The Gleason grading system for prostate cancer (PCa) is based on the proportions of Gleason patterns (GP) 3-5. While pu …
Sensitive fiber-optic localized surface plasmon resonance sensor for early pancreatic cancer detection via carbohydrate antigen 19-9 and supplementary biomarkers.
Kim HM, Kim MJ, Sung W, Youn Y, Park J, Hwang JH, Lee JC, Yoon S, Park JH, Lee SK. Kim HM, et al. Talanta. 2026 Mar 1;299:129133. doi: 10.1016/j.talanta.2025.129133. Epub 2025 Nov 19. Talanta. 2026. PMID: 41289778
Early detection of pancreatic cancer remains a major clinical challenge with the limited specificity of representative biomarker such as carbohydrate antigen 19-9 (CA19-9). ...This study describes the potential of CA19-9 as an indicator for early diagn …
Early detection of pancreatic cancer remains a major clinical challenge with the limited specificity of representative …
Mapping Ibero-American nonprofit efforts in advocacy for head and neck cancer patients: a scoping review.
Dutra MJ, Carnevali LF, Schuch LF, Silveira FM, Santos-Silva AR, Martins MD, Wagner VP. Dutra MJ, et al. Oral Surg Oral Med Oral Pathol Oral Radiol. 2026 Mar;141(3):343-350. doi: 10.1016/j.oooo.2025.10.010. Epub 2025 Oct 24. Oral Surg Oral Med Oral Pathol Oral Radiol. 2026. PMID: 41285647
Articles mentioning any NPGorO related to HNC or thyroid cancer in the IAR were included, despite their differing epidemiology and clinical context. ...Most websites (n = 18; 94.73%) provided information on risk factors, signs, symptoms, screening, diagnosis, and tr …
Articles mentioning any NPGorO related to HNC or thyroid cancer in the IAR were included, despite their differing epidemiology and cl …
Incidence and risk factors for malignancy after heart transplantation- Analysis of the UNOS Registry.
Magod BL, Hughes ZH, Manjunath A, Wu T, Harrap R, Bryner B, Lewsey S, Ghafourian K, Oputa O, Pham D, Rasberry K, Tibrewala A, Wilcox J, Youmans QR, Okwuosa IS. Magod BL, et al. Am Heart J. 2026 Mar;293:107308. doi: 10.1016/j.ahj.2025.107308. Epub 2025 Nov 21. Am Heart J. 2026. PMID: 41275897
BACKGROUND: Malignancy threatens to limit survival in heart transplant recipients. Improved understanding of cancer risk is needed to direct prevention and screening strategies following heart transplantation. ...Hospitalization for infection is a risk factor that h …
BACKGROUND: Malignancy threatens to limit survival in heart transplant recipients. Improved understanding of cancer risk is needed to …
A multifunctional nanosystem based on sodium nitroprusside/copper co-doped dopamine-coated Prussian blue nanoparticles with enhanced photothermal capability for combined cancer therapy.
Liao T, Chen J, Li L, Wang J, Zhang S, Liu J, Kuang Y, Li C. Liao T, et al. Colloids Surf B Biointerfaces. 2026 Mar;259:115298. doi: 10.1016/j.colsurfb.2025.115298. Epub 2025 Nov 20. Colloids Surf B Biointerfaces. 2026. PMID: 41273896
Cancer remains a significant global health challenge requiring advanced therapeutic strategies to minimize off-target effects. ...This design exemplifies a precision nanomedicine strategy that uses endogenous stimuli and exogenous activation to effectively treat cancer …
Cancer remains a significant global health challenge requiring advanced therapeutic strategies to minimize off-target effects. ...Thi …
Noninvasive nasopharyngeal cancer screening via salivary DNA detection using label-free surface-enhanced Raman spectroscopy.
Hou S, Wu Q, Qiu S, Weng Y, Lin D. Hou S, et al. Talanta. 2026 Mar 1;299:129113. doi: 10.1016/j.talanta.2025.129113. Epub 2025 Nov 13. Talanta. 2026. PMID: 41265314
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the mucosal epithelium of the nasopharynx, which has a high incidence in southern China and Southeast Asia, and is often delayed in diagnosis due to insidious early symptoms. Currently, the diagnosis of N …
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the mucosal epithelium of the nasopharynx, which has a high incidence i …
Novel nanoparticle-combined therapy through EGFR and PD-L1 blockade: PFPR-siRNA-mediated suppressing NSCLC proliferation via PDT and enhanced antitumor immunity.
Zhang M, Xie N, Wu D, Wu C, Guo Y, Wang N, Li XY, Liang Y, Xie X, Wang T, Li YJ, Ning F, Wang RR, Xie SY, Wang PY. Zhang M, et al. Colloids Surf B Biointerfaces. 2026 Mar;259:115284. doi: 10.1016/j.colsurfb.2025.115284. Epub 2025 Nov 17. Colloids Surf B Biointerfaces. 2026. PMID: 41265187
EGFR-targeted therapy and anti-PD-1/PD-L1 immunotherapy are crucial in treating advanced or metastatic non-small cell lung cancer (NSCLC). However, therapeutic drug resistance frequently develops, leading to treatment failure. ...
EGFR-targeted therapy and anti-PD-1/PD-L1 immunotherapy are crucial in treating advanced or metastatic non-small cell lung cancer (NS …
Investigations of potential therapeutic targets from high-throughput, label-free, quantitative proteomic studies in MDA-MB-468 cells treated with metformin and electrical pulses.
Sahu P, Camarillo IG, Sundararajan R. Sahu P, et al. Bioelectrochemistry. 2026 Mar;168:109153. doi: 10.1016/j.bioelechem.2025.109153. Epub 2025 Oct 24. Bioelectrochemistry. 2026. PMID: 41232409
High-throughput, label-free quantitative proteomic analyses, along with cell viability and reactive oxygen species (ROS) studies, were performed on MDA-MB-468 human triple-negative breast cancer (TNBC) cells, to gain mechanistic insights into therapeutic actions. TNBC was …
High-throughput, label-free quantitative proteomic analyses, along with cell viability and reactive oxygen species (ROS) studies, were perfo …
Early Detection of Metastatic Progression by Circulating Tumor DNA in Patients Undergoing Bladder-Preserving Trimodality Therapy.
Zhao D, Khatri VM, Nakashima JY, Chadha J, Chatwal M, Zhang J, Ionescu F, Linscott JA, Li R, Poch M, Sexton W, Yu A, Spiess PE, Zemp L, Gilbert SM, Manley B, Yin V, Jain R, Torres-Roca J, Johnstone P, Yamoah K, Grass GD. Zhao D, et al. J Urol. 2026 Mar;215(3):305-315. doi: 10.1097/JU.0000000000004849. Epub 2025 Nov 13. J Urol. 2026. PMID: 41231842
PURPOSE: Radical cystectomy and trimodality therapy (TMT) are efficacious treatments for muscle invasive bladder cancer. Novel methods for post-treatment surveillance are needed to detect recurrence. ...CONCLUSIONS: Plasma ctDNA is a potential biomarker for early …
PURPOSE: Radical cystectomy and trimodality therapy (TMT) are efficacious treatments for muscle invasive bladder cancer. Novel method …
A novel dual-effect bimodal chip cancer research platform: Chips system interconnected vascularized tumor organoids culture with real-time exploration and detection from bench to bedside.
Ruan J, Gao C, Wang R, Hu B, Long R, Hacimuftuoglu A, Liao B, Chen L, Ma D, Xi L, Li L, Liao S. Ruan J, et al. Cancer Lett. 2026 Mar 1;640:218110. doi: 10.1016/j.canlet.2025.218110. Epub 2025 Nov 4. Cancer Lett. 2026. PMID: 41198016
Nowadays, cancer researches widely employed organoids as research model. Organoids provide a realistic applicate scene but how to real-time detect and quantified the organoid status is still a bottleneck. ...By combining these two systems, our dual-effect bimodal chip plat …
Nowadays, cancer researches widely employed organoids as research model. Organoids provide a realistic applicate scene but how to rea …
A Cost Consequence Analysis of Seven Diagnostic Strategies for Ovarian Cancer: A Model-Based Economic Evaluation.
Perry SJ, Griffin D, Williams EV, Roberts TE, Kwong FL, Williams S, Deeks J, Scandrett K, Agarwal R, Sundar SS, Monahan M. Perry SJ, et al. BJOG. 2026 Mar;133(4):680-689. doi: 10.1111/1471-0528.70074. Epub 2025 Nov 5. BJOG. 2026. PMID: 41194592 Free PMC article.
Across both cohorts, the Risk of Malignancy Index (RMI) 200 was least expensive but had poor cancer death and diagnostic yield outcomes. The ADNEX 3% strategy had the highest diagnostic yield and lowest cancer mortality but was the most expensive. ...CONCLUSION: At …
Across both cohorts, the Risk of Malignancy Index (RMI) 200 was least expensive but had poor cancer death and diagnostic yield outcom …
Sustained impact of bivalent HPV immunisation on CIN incidence over two rounds of cervical screening.
Palmer TJ, Kavanagh K, Cuschieri K, Cameron RL, Graham C, Wilson A, Roy K. Palmer TJ, et al. Int J Cancer. 2026 Mar 1;158(5):1348-1360. doi: 10.1002/ijc.70183. Epub 2025 Nov 3. Int J Cancer. 2026. PMID: 41185413 Free PMC article.
Vaccination with the bivalent vaccine (3 dose schedule) for women aged 12-18 years began in Scotland in 2008; immunised women entered screening in 2010. Women immunised at age12-13 years entered screening in 2015. Linked data from 12 years of routine screening …
Vaccination with the bivalent vaccine (3 dose schedule) for women aged 12-18 years began in Scotland in 2008; immunised women entered scr …
The Association between Binge Drinking and Mammography and Pap Test Screening by Women's Race and Ethnicity.
La Frinere-Sandoval NQNB, Cubbin C, DiNitto DM. La Frinere-Sandoval NQNB, et al. J Womens Health (Larchmt). 2026 Mar;35(3):306-317. doi: 10.1177/15409996251391064. Epub 2025 Nov 3. J Womens Health (Larchmt). 2026. PMID: 41182292
Some studies indicate that excessive drinking is associated with lower rates of mammogram screening, but information by racial/ethnic group is lacking. We explored the relationship between binge drinking and mammogram and Pap test use among Asian, Black, Hispanic, and Whit …
Some studies indicate that excessive drinking is associated with lower rates of mammogram screening, but information by racial/ethnic …
Detection of small pancreatic ductal adenocarcinoma: The potential of cinematic rendering in earlier lesion detection.
Arshad H, Krueger S, Chu LC, Fishman EK. Arshad H, et al. Curr Probl Diagn Radiol. 2026 Mar-Apr;55(2):339-347. doi: 10.1067/j.cpradiol.2025.10.018. Epub 2025 Oct 25. Curr Probl Diagn Radiol. 2026. PMID: 41177711 Review.
Cinematic rendering (CR) is a novel three-dimensional post-processing technique that accentuates subtle textural differences and holds the potential to improve detection of small tumors. It utilizes a complex global lighting model generating photorealistic images with enha …
Cinematic rendering (CR) is a novel three-dimensional post-processing technique that accentuates subtle textural differences and holds the p …
Histone lactylation promoted colorectal cancer progression by enhancing tumor necrosis factor transcription and served as a diagnostic biomarker.
Li S, Shi X, Zhou X. Li S, et al. Anticancer Drugs. 2026 Mar 1;37(3):245-251. doi: 10.1097/CAD.0000000000001771. Epub 2025 Oct 20. Anticancer Drugs. 2026. PMID: 41176660
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with unmet needs for early diagnostic biomarkers and therapeutic targets. ...These findings position H3K18la as a novel therapeutic target for CRC and underscore its potenti …
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with unmet needs for early diagno …
Circulating cell-free DNA methylation biomarkers for hepatocellular carcinoma risk prediction in HIV-positive Nigerian population.
Zheng Y, Han J, Qu Y, Wang J, Joyce BT, Okeke E, Davwar PM, Duguru MJ, Nyam DP, Odeghe E, Oyeleke G, Lesi OA, Imade GE, Sulaimon AA, Hawkins C, Abdulkareem FB, Badmos K, Gursel DB, Wei JJ, Silas OA, Kocherginsky M, Kim KA, Sun Z, Achenbach CJ, Zhang X, Yang H, Sagay AS, Ogunsola FT, Murphy RL, Roberts LR, Hou L. Zheng Y, et al. Int J Cancer. 2026 Mar 1;158(5):1281-1291. doi: 10.1002/ijc.70204. Epub 2025 Oct 23. Int J Cancer. 2026. PMID: 41129333
Effective early detection remains a major challenge due to limited access to imaging-based surveillance and the low sensitivity of current biomarkers such as alpha-fetoprotein (AFP). ...Notably, ccfDNA methylation patterns displayed clear dose-response relationships …
Effective early detection remains a major challenge due to limited access to imaging-based surveillance and the low sensitivit …
The Differential Diagnostic Value of Ultrasound Radiomics in TI-RADS 4a Follicular Thyroid Neoplasms.
Zhao YY, Li WW, Tao LL, Zhan WW, Zhou W. Zhao YY, et al. Ultrason Imaging. 2026 Mar;48(2):74-82. doi: 10.1177/01617346251382464. Epub 2025 Oct 21. Ultrason Imaging. 2026. PMID: 41117500
A retrospective analysis was conducted on the ultrasound images from 144 patients with TI-RADS 4a follicular thyroid neoplasms who underwent their first surgery in our hospital from January 2018 to June 2024. ...One hundred forty-four patients with TI-RADS 4a follicular th …
A retrospective analysis was conducted on the ultrasound images from 144 patients with TI-RADS 4a follicular thyroid neoplasms who un …
Single visit screen-triage-treat strategy using GeneXpert-based HPV testing of self-collected cervicovaginal samples and thermal ablation treatment for cervical cancer prevention among women in Lilongwe, Malawi.
Chinula L, Chagomerana MB, Mkochi T, Msowoya L, Nakanga C, Saidi F, Ndovie M, Kampani C, Tomoka T, Smith JS, O'Connor S, Mwapasa V, Tang JH. Chinula L, et al. Int J Cancer. 2026 Mar 1;158(5):1323-1335. doi: 10.1002/ijc.70177. Epub 2025 Oct 16. Int J Cancer. 2026. PMID: 41099603
Human papillomavirus (HPV) testing is now recommended for primary screening for invasive cervical cancer (ICC) among women. We evaluated same-day completion of an HPV screen-triage-treat algorithm consisting of: (1) GeneXpert high-risk HPV testing of self-collected …
Human papillomavirus (HPV) testing is now recommended for primary screening for invasive cervical cancer (ICC) among women. We …
Under which realistic circumstances is hrHPV self-sampling increasing cervical screening effectiveness in a partly vaccinated population? A modelling study.
Kaljouw S, Jansen EEL, Olthof EMG, Hontelez JAC, de Kok IMCM. Kaljouw S, et al. Int J Cancer. 2026 Mar 1;158(5):1361-1369. doi: 10.1002/ijc.70184. Epub 2025 Oct 9. Int J Cancer. 2026. PMID: 41065509 Free PMC article.
High-risk Human Papillomavirus self-sampling can increase attendance rates for screening. However, observed lower sensitivity and loss to follow-up of self-sampling could reduce programme effectiveness when attenders of clinician-collected sampling switch to self-sampling. …
High-risk Human Papillomavirus self-sampling can increase attendance rates for screening. However, observed lower sensitivity and los …
Risk of advanced adenoma detection in colorectal cancer screening programmes according to personal characteristics and screening history.
Vanaclocha-Espí M, Romeo-Cervera P, Castan-Cameo S, Pérez-Sanz E, Ibañez J, Llorens-Ivorra C, Risueño-Albuixech R, Besó M, Molina-Barceló A. Vanaclocha-Espí M, et al. Int J Cancer. 2026 Mar 1;158(5):1272-1280. doi: 10.1002/ijc.70182. Epub 2025 Oct 6. Int J Cancer. 2026. PMID: 41051172 Free PMC article.
The detection of advanced adenomas (AA) is an important benefit-relevant indicator in colorectal cancer screening programmes (CRCSP). ...We analysed the risk of AA and the influence of factors related to screening history in the first screening …
The detection of advanced adenomas (AA) is an important benefit-relevant indicator in colorectal cancer screening progr …
Impact of geriatric impairments on outcomes of single-agent immunotherapy in solid tumors.
Özkan A, de Joode K, Kapiteijn E, Slingerland M, Zunder S, van den Bos F, Mooijaart S, Uit den Boogaard A, Trompet S, Westgeest H, van der Veldt A, Mathijssen RHJ, Labots G, Holterhues C, Verdegaal EME, de Glas NA, Portielje JEA. Özkan A, et al. Int J Cancer. 2026 Mar 1;158(5):1370-1382. doi: 10.1002/ijc.70185. Epub 2025 Oct 4. Int J Cancer. 2026. PMID: 41045448 Free PMC article.
Cancer is increasingly prevalent among older adults with geriatric impairments, yet the impact of frailty on immune checkpoint inhibitor (ICI) therapy outcomes remains underexplored. ...
Cancer is increasingly prevalent among older adults with geriatric impairments, yet the impact of frailty on immune checkpoint inhibi …
Socioeconomic differences among patients with stage I-III colon cancer: Detection, treatment and relative survival.
van Erning FN, Galanos LJK, Lurvink R, Aarts MJ, van Hellemond IEG, Nagtegaal ID, de Hingh IHJT, de Wilt JHW, Elferink MAG. van Erning FN, et al. Int J Cancer. 2026 Mar 1;158(5):1262-1271. doi: 10.1002/ijc.70181. Epub 2025 Oct 2. Int J Cancer. 2026. PMID: 41037772
This study investigates associations between SEP and screening versus clinical detection, treatment characteristics, and relative survival. Patients with stage I-III colon cancer diagnosed between 2015 and 2023 were selected from the Netherlands Cancer …
This study investigates associations between SEP and screening versus clinical detection, treatment characteristics, and relat …
Assessing the Implementation of Electronic Patient-Reported Outcomes (ePRO) to Reduce Follow-up Visits for Patients Undergoing Radiation Therapy for Breast Cancer.
Teles MS, Lapen K, Huang J, Mao JJ, Bernstein MB, Braunstein LZ, Khan AJ, Daly B, Gillespie EF. Teles MS, et al. Int J Radiat Oncol Biol Phys. 2026 Mar 1;124(3):641-646. doi: 10.1016/j.ijrobp.2025.09.027. Epub 2025 Sep 28. Int J Radiat Oncol Biol Phys. 2026. PMID: 41027545
PURPOSE: We aimed to evaluate the acceptability, appropriateness, and feasibility of using an electronic patient-reported outcome (ePRO)-based strategy to reduce postradiation therapy (RT) visits in patients with breast cancer who reported minimal symptoms. METHODS AND MAT …
PURPOSE: We aimed to evaluate the acceptability, appropriateness, and feasibility of using an electronic patient-reported outcome (ePRO)-bas …
An electrochemical aptasensor based on synergistic effect of duplex-specific nuclease and nanoporous gold for ultrasensitive detection of prostate-specific antigen.
Wang X, Li X, Xie Y, Fang H, Cui X, Jiao J, Zhang Y. Wang X, et al. Bioelectrochemistry. 2026 Mar;168:109113. doi: 10.1016/j.bioelechem.2025.109113. Epub 2025 Sep 19. Bioelectrochemistry. 2026. PMID: 40992160
Benefiting from the synergistic effect of DSN and NP-Gold, the developed aptasensor showed a wide linear relationship between current values and PSA concentrations, with a detection range from 100 fg/mL to 10 ng/mL and a limit of detection (LOD) of 2.7 fg/mL. ...The …
Benefiting from the synergistic effect of DSN and NP-Gold, the developed aptasensor showed a wide linear relationship between current values …
Industry Sponsorship and Disease Site Focus in Therapeutic Radiopharmaceutical Clinical Trials Over the Past Decade.
Howell JN, Wilkes J, Maughan NM, Patel RB, Barney B, Taunk NK, Escorcia FE, Johnson SB, Boothe D. Howell JN, et al. Int J Radiat Oncol Biol Phys. 2026 Mar 1;124(3):575-580. doi: 10.1016/j.ijrobp.2025.09.028. Epub 2025 Sep 19. Int J Radiat Oncol Biol Phys. 2026. PMID: 40976311 Free article.
RESULTS: The initial searches yielded 856 RPT clinical trials. After screening, 254 RPT trials were analyzed. The total number of annual trial postings demonstrated considerable growth during this period, with an approximate 13.0% year-over-year increase between 2014 and 2 …
RESULTS: The initial searches yielded 856 RPT clinical trials. After screening, 254 RPT trials were analyzed. The total number of ann …
Transgender Men's and Non-Binary People's Experiences of Cervical Cancer Screening-A Journey Mapping Approach.
Kleijberg M, Eriksson LE. Kleijberg M, et al. J Clin Nurs. 2026 Mar;35(3):1433-1445. doi: 10.1111/jocn.70113. Epub 2025 Sep 19. J Clin Nurs. 2026. PMID: 40970568 Free PMC article.
AIM: To explore the experiences of cervical cancer screening in Sweden among transgender people who were assigned female at birth, and to identify touchpoints in need of improvement along the cervical cancer screening trajectory. ...CONCLUSION: To make …
AIM: To explore the experiences of cervical cancer screening in Sweden among transgender people who were assigned female at bi …
An electrochemical biosensor for immobilization coupling and quantifying exosomes based on a UiO-66 metal-organic framework.
Wang Z, Fan X, Hu X, Wang X. Wang Z, et al. Bioelectrochemistry. 2026 Mar;168:109108. doi: 10.1016/j.bioelechem.2025.109108. Epub 2025 Sep 13. Bioelectrochemistry. 2026. PMID: 40957130
The biosensor demonstrated a higher sensitivity than most previously described approaches, with a wider linear range (10(2) to 5 10(6) particles/muL) and a lower limit of detection (7 particles/muL). Moreover, the biosensor exhibited clinical potential by selectively bindi …
The biosensor demonstrated a higher sensitivity than most previously described approaches, with a wider linear range (10(2) to 5 10(6) parti …
Overdiagnosis of thyroid cancer in the United States: Improved estimates based on the SEER registries during 2000-2019.
Zhang M, Xie D, Hu Y, Qin G, Xu W. Zhang M, et al. Int J Cancer. 2026 Mar 1;158(5):1215-1226. doi: 10.1002/ijc.70143. Epub 2025 Sep 12. Int J Cancer. 2026. PMID: 40938315
The rising thyroid cancer (TC) incidence is largely attributed to overdiagnosis, primarily due to widespread use of sensitive imaging technologies. ...This study presents refined estimates of TC overdiagnosis and highlights the continued impact of early detection …
The rising thyroid cancer (TC) incidence is largely attributed to overdiagnosis, primarily due to widespread use of sensitive imaging …
Wearable bioelectronics for skin cancer management.
Liang G, Chen S, Chen J. Liang G, et al. Biomaterials. 2026 Mar;326:123669. doi: 10.1016/j.biomaterials.2025.123669. Epub 2025 Aug 30. Biomaterials. 2026. PMID: 40925056 Review.
This review systematically examines the recent advancements in wearable bioelectronics for skin cancer management. Firstly, the pathological mechanisms underlying skin cancer is discussed. Next, we discuss the wearable optical and electrochemical sensing technologie …
This review systematically examines the recent advancements in wearable bioelectronics for skin cancer management. Firstly, the patho …
Comparison of iBreastExam with clinical breast examination for early detection of breast cancer in community outreach clinics in Pune, India.
Joshi SN, Dharpawar TS, Kulkarni SR, Chaudhari PS, Wadhwa OS, Kishore Kumar B, Sankaranarayanan R. Joshi SN, et al. Int J Cancer. 2026 Mar 1;158(5):1204-1214. doi: 10.1002/ijc.70137. Epub 2025 Sep 6. Int J Cancer. 2026. PMID: 40913407
We conducted a cross-sectional study to evaluate the agreement between iBreastExam (iBE) and CBE for early detection of breast cancers. Women aged 40 to 69 years were screened at community outreach clinics after obtaining a written informed consent. ...Refinement of …
We conducted a cross-sectional study to evaluate the agreement between iBreastExam (iBE) and CBE for early detection of breast …
Fabrication of phenylboronic acid modified graphene oxide-silica biosensor for label-free electrochemical detection of circulating tumor cells.
Iqbal S, Jabeen F, Bashir N, Naqvi STR, Majeed S, Rasul A, Najam-Ul-Haq M. Iqbal S, et al. Bioelectrochemistry. 2026 Mar;168:109098. doi: 10.1016/j.bioelechem.2025.109098. Epub 2025 Sep 1. Bioelectrochemistry. 2026. PMID: 40907085
Early and accurate detection of circulating tumor cells (CTCs) is vital for cancer diagnosis and personalized treatment. ...
Early and accurate detection of circulating tumor cells (CTCs) is vital for cancer diagnosis and personalized treatment …
Development and Performance Validation of a Comprehensive Liquid Biopsy Genotyping Panel for Pan-cancer Analysis.
Lim S, Lee KS, Won D, Seo SH, Lee ST, Choi JR, Seo J, Shin S. Lim S, et al. Ann Lab Med. 2026 Mar 1;46(2):210-219. doi: 10.3343/alm.2025.0171. Epub 2025 Sep 1. Ann Lab Med. 2026. PMID: 40888113 Free article.
Liquid biopsy using circulating tumor DNA (ctDNA) enables real-time molecular profiling, treatment monitoring, and early detection of resistance variants. We developed the PAN100 panel (Dxome), a hybridization capture panel targeting 101 genes, as a pan-cancer …
Liquid biopsy using circulating tumor DNA (ctDNA) enables real-time molecular profiling, treatment monitoring, and early detection …
Inflammatory breast cancer: Can contrast enhanced mammography help? Case series and literature review.
Snyder S, Patel P, Ives E, Roth R, Loveland-Jones CE, Germaine P. Snyder S, et al. Curr Probl Diagn Radiol. 2026 Mar-Apr;55(2):333-338. doi: 10.1067/j.cpradiol.2025.08.013. Epub 2025 Aug 21. Curr Probl Diagn Radiol. 2026. PMID: 40885692 Review.
Inflammatory breast cancer (IBC) is an uncommon, locally aggressive breast cancer with rapid onset of symptoms and an unfavorable prognosis. ...Current applications of CEM include the evaluation of abnormal findings on screening mammography, monitoring respon …
Inflammatory breast cancer (IBC) is an uncommon, locally aggressive breast cancer with rapid onset of symptoms and an unfavora …
Breast Cancer Screening: A Decade of Progress.
Iordanishvili E, Bode M, Morscheid S, Lemainque T, Kuhl CK. Iordanishvili E, et al. Invest Radiol. 2026 Mar 1;61(3):205-213. doi: 10.1097/RLI.0000000000001216. Invest Radiol. 2026. PMID: 40622332 Review.
This review is dedicated to the 60th anniversary of Investigative Radiology and focuses on significant development made in the field of breast cancer screening in the past decade since the last anniversary article, and builds on it. ...
This review is dedicated to the 60th anniversary of Investigative Radiology and focuses on significant development made in the field of brea …
Factors associated with the likelihood of being diagnosed with stage I melanoma in Germany: a multicenter study on 12 648 patients from the ADOReg skin cancer registry.
Kostev K, Rodemer I, Alymova S, Konrad M. Kostev K, et al. Eur J Cancer Prev. 2026 Mar 1;35(2):166-172. doi: 10.1097/CEJ.0000000000000970. Epub 2025 Apr 18. Eur J Cancer Prev. 2026. PMID: 40278221
BACKGROUND: The aim of the present study was to evaluate the factors associated with a higher or lower likelihood of being early diagnosed with melanoma at stage I in Germany. METHODS: This retrospective cross-sectional study utilizes data from the German skin cancer …
BACKGROUND: The aim of the present study was to evaluate the factors associated with a higher or lower likelihood of being early diag …
The accuracy of administrative data in identifying pulmonary metastases: a population-based study in Northern Italy.
Marinelli F, Braghiroli MB, Bisceglia I, Roncaglia F, Pezzarossi A, Morabito F, Neri A, Giorgi Rossi P, Mangone L. Marinelli F, et al. Eur J Cancer Prev. 2026 Mar 1;35(2):160-165. doi: 10.1097/CEJ.0000000000000964. Epub 2025 Mar 26. Eur J Cancer Prev. 2026. PMID: 40177993 Free PMC article.
OBJECTIVE: Lung cancer remains a highly prevalent and lethal disease, with the majority of tumors identified at advanced stages. Screening with low-dose CT was shown to be effective in reducing mortality through early diagnosis. ...
OBJECTIVE: Lung cancer remains a highly prevalent and lethal disease, with the majority of tumors identified at advanced stages. S …
Cancer mortality predictions for 2025 in Latin America with focus on prostate cancer.
Mignozzi S, Santucci C, Levi F, Malvezzi M, Boffetta P, Corso G, Negri E, La Vecchia C. Mignozzi S, et al. Eur J Cancer Prev. 2026 Mar 1;35(2):97-107. doi: 10.1097/CEJ.0000000000000959. Epub 2025 Feb 25. Eur J Cancer Prev. 2026. PMID: 40029692 Free PMC article.
We provided cancer mortality rate estimates for the year 2025 in six Latin American countries (Argentina, Brazil, Chile, Colombia, Cuba, and Mexico), focusing on prostate cancer. ...Except for uterine, stomach, and prostate cancers, cancer mortality rates are …
We provided cancer mortality rate estimates for the year 2025 in six Latin American countries (Argentina, Brazil, Chile, Colombia, Cu …
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