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Use of ondansetron during pregnancy and congenital malformations in the infant.
Danielsson B, Wikner BN, Källén B. Danielsson B, et al. Reprod Toxicol. 2014 Dec;50:134-7. doi: 10.1016/j.reprotox.2014.10.017. Epub 2014 Oct 31. Reprod Toxicol. 2014. PMID: 25450422
In a Mantel-Haenszel analysis adjustment was made for year of delivery, maternal age, parity, smoking in early pregnancy and pre-pregnancy body mass index. Risks were expressed as odds or risk ratios with 95% confidence intervals. ...The teratogenic …
In a Mantel-Haenszel analysis adjustment was made for year of delivery, maternal age, parity, smoking in early pregnancy and p …
Ondansetron Use in Pregnancy and Birth Defects: A Systematic Review.
Carstairs SD. Carstairs SD. Obstet Gynecol. 2016 May;127(5):878-883. doi: 10.1097/AOG.0000000000001388. Obstet Gynecol. 2016. PMID: 27054939 Review.
OBJECTIVE: To examine the risk of birth defects in children born to women who used ondansetron early in pregnancy for nausea and vomiting of pregnancy or hyperemesis gravidarum. ...There may be a small increase in the incidence of cardiac abn
OBJECTIVE: To examine the risk of birth defects in children born to women who used ondansetron early in pregnancy
Major Congenital Malformation Risk After First Trimester Gestational Exposure to Oral or Intravenous Ondansetron.
Andrade C. Andrade C. J Clin Psychiatry. 2020 Jun 2;81(3):20f13472. doi: 10.4088/JCP.20f13472. J Clin Psychiatry. 2020. PMID: 32526103 Free article. Review.
The drug is commonly used off-label to treat nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum (HG). Ondansetron crosses the placental barrier, and concerns have been expressed that using ondansetron for NVP/HG during the first trimester of …
The drug is commonly used off-label to treat nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum (HG). Ondansetron
First trimester ondansetron exposure and risk of structural birth defects.
Zambelli-Weiner A, Via C, Yuen M, Weiner DJ, Kirby RS. Zambelli-Weiner A, et al. Reprod Toxicol. 2019 Jan;83:14-20. doi: 10.1016/j.reprotox.2018.10.010. Epub 2018 Oct 29. Reprod Toxicol. 2019. PMID: 30385129
First trimester exposure to ondansetron was associated with increased risk of cardiac (OR: 1.52 95% CI: 1.35-1.70) and orofacial cleft defects (OR: 1.32 95% CI: 0.76-2.28) in offspring compared to women with no antiemetic exposure during pregnancy. ...In a la …
First trimester exposure to ondansetron was associated with increased risk of cardiac (OR: 1.52 95% CI: 1.35-1.70) and orofaci …
Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.
Danielsson B, Webster WS, Ritchie HE. Danielsson B, et al. Reprod Toxicol. 2018 Oct;81:237-245. doi: 10.1016/j.reprotox.2018.08.018. Epub 2018 Aug 24. Reprod Toxicol. 2018. PMID: 30149139
The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy. ...Cardiovascular malformations in rats occurred at exposures slightly higher than those in early human pregnancy
The potent hERG channel blocking drug ondansetron is used off-label for treatment of nausea and vomiting in early pregnancy
Ondansetron and pregnancy: possible congenital heart defects.
[No authors listed] [No authors listed] Prescrire Int. 2016 May;25(171):129-30. Prescrire Int. 2016. PMID: 27280199
Two cohort studies, including more than 2500 pregnant women exposed to ondansetron in early pregnancy, have raised concerns over an increased risk of congenital heart defects....
Two cohort studies, including more than 2500 pregnant women exposed to ondansetron in early pregnancy, have raised conc …