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Molecular pathogenesis of ADPKD: the polycystin complex gets complex.
Ong AC, Harris PC. Ong AC, et al. Kidney Int. 2005 Apr;67(4):1234-47. doi: 10.1111/j.1523-1755.2005.00201.x. Kidney Int. 2005. PMID: 15780076
Polycystin-2 expression is increased following experimental ischaemic renal injury.
Zhao Y, Haylor JL, Ong AC. Zhao Y, et al. Among authors: ong ac. Nephrol Dial Transplant. 2002 Dec;17(12):2138-44. doi: 10.1093/ndt/17.12.2138. Nephrol Dial Transplant. 2002. PMID: 12454224
Polycystic kidney disease--the ciliary connection.
Ong AC, Wheatley DN. Ong AC, et al. Lancet. 2003 Mar 1;361(9359):774-6. doi: 10.1016/S0140-6736(03)12662-1. Lancet. 2003. PMID: 12620752
Functional analysis of PKD1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion.
Streets AJ, Newby LJ, O'Hare MJ, Bukanov NO, Ibraghimov-Beskrovnaya O, Ong AC. Streets AJ, et al. Among authors: ong ac. J Am Soc Nephrol. 2003 Jul;14(7):1804-15. doi: 10.1097/01.asn.0000076075.49819.9b. J Am Soc Nephrol. 2003. PMID: 12819240
Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype.
Rossetti S, Chauveau D, Kubly V, Slezak JM, Saggar-Malik AK, Pei Y, Ong AC, Stewart F, Watson ML, Bergstralh EJ, Winearls CG, Torres VE, Harris PC. Rossetti S, et al. Among authors: ong ac. Lancet. 2003 Jun 28;361(9376):2196-201. doi: 10.1016/S0140-6736(03)13773-7. Lancet. 2003. PMID: 12842373 Clinical Trial.
Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected.
Le NH, van der Bent P, Huls G, van de Wetering M, Loghman-Adham M, Ong AC, Calvet JP, Clevers H, Breuning MH, van Dam H, Peters DJ. Le NH, et al. Among authors: ong ac. J Biol Chem. 2004 Jun 25;279(26):27472-81. doi: 10.1074/jbc.M312183200. Epub 2004 Apr 15. J Biol Chem. 2004. PMID: 15087466
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.
Streets AJ, Moon DJ, Kane ME, Obara T, Ong AC. Streets AJ, et al. Among authors: ong ac. Hum Mol Genet. 2006 May 1;15(9):1465-73. doi: 10.1093/hmg/ddl070. Epub 2006 Mar 21. Hum Mol Genet. 2006. PMID: 16551655 Free PMC article.
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