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Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors.
Papadaki P, Pizon V, Onken B, Chang EC. Papadaki P, et al. Among authors: onken b. Mol Cell Biol. 2002 Jul;22(13):4598-606. doi: 10.1128/mcb.22.13.4598-4606.2002. Mol Cell Biol. 2002. PMID: 12052869 Free PMC article.
Compartmentalized signaling of Ras in fission yeast.
Onken B, Wiener H, Philips MR, Chang EC. Onken B, et al. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9045-50. doi: 10.1073/pnas.0603318103. Epub 2006 Jun 5. Proc Natl Acad Sci U S A. 2006. PMID: 16754851 Free PMC article.
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.
Onken B, Driscoll M. Onken B, et al. PLoS One. 2010 Jan 18;5(1):e8758. doi: 10.1371/journal.pone.0008758. PLoS One. 2010. PMID: 20090912 Free PMC article.
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. Hansen M, et al. Among authors: onken b. PLoS Genet. 2008 Feb;4(2):e24. doi: 10.1371/journal.pgen.0040024. PLoS Genet. 2008. PMID: 18282106 Free PMC article.
Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan.
Vora M, Shah M, Ostafi S, Onken B, Xue J, Ni JZ, Gu S, Driscoll M. Vora M, et al. Among authors: onken b. PLoS Genet. 2013 Aug;9(8):e1003737. doi: 10.1371/journal.pgen.1003737. Epub 2013 Aug 29. PLoS Genet. 2013. PMID: 24009527 Free PMC article.
Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves.
Chen Y, Onken B, Chen H, Xiao S, Liu X, Driscoll M, Cao Y, Huang Q. Chen Y, et al. Among authors: onken b. J Agric Food Chem. 2014 Apr 16;62(15):3422-31. doi: 10.1021/jf500210p. Epub 2014 Apr 7. J Agric Food Chem. 2014. PMID: 24701969
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Lucanic M, et al. Among authors: onken b. Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256. Nat Commun. 2017. PMID: 28220799 Free PMC article.
Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.
Banse SA, Lucanic M, Sedore CA, Coleman-Hulbert AL, Plummer WT, Chen E, Kish JL, Hall D, Onken B, Presley MP, Jones EG, Blue BW, Garrett T, Abbott M, Xue J, Guo S, Johnson E, Foulger AC, Chamoli M, Falkowski R, Melentijevic I, Harinath G, Huynh P, Patel S, Edgar D, Jarrett CM, Guo M, Kapahi P, Lithgow GJ, Driscoll M, Phillips PC. Banse SA, et al. Among authors: onken b. Geroscience. 2019 Dec;41(6):945-960. doi: 10.1007/s11357-019-00108-9. Epub 2019 Dec 10. Geroscience. 2019. PMID: 31820364 Free PMC article.
Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension.
Onken B, Kalinava N, Driscoll M. Onken B, et al. PLoS Genet. 2020 Aug 25;16(8):e1008982. doi: 10.1371/journal.pgen.1008982. eCollection 2020 Aug. PLoS Genet. 2020. PMID: 32841230 Free PMC article.
Healthy lifespan extension mediated by oenothein B isolated from Eucalyptus grandis × Eucalyptus urophylla GL9 in Caenorhabditis elegans.
Chen Y, Onken B, Chen H, Zhang X, Driscoll M, Cao Y, Huang Q. Chen Y, et al. Among authors: onken b. Food Funct. 2020 Mar 26;11(3):2439-2450. doi: 10.1039/c9fo02472g. Food Funct. 2020. PMID: 32129349