Orchard R - Search Results

1

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE. Doench JG, et al. Among authors: orchard r. Nat Biotechnol. 2016 Feb;34(2):184-191. doi: 10.1038/nbt.3437. Epub 2016 Jan 18. Nat Biotechnol. 2016. PMID: 26780180 Free PMC article.

2

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.

Martinez J, Malireddi RK, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Guan JL, Tan H, Peng J, Kanneganti TD, Virgin HW, Green DR. Martinez J, et al. Among authors: orchard r. Nat Cell Biol. 2015 Jul;17(7):893-906. doi: 10.1038/ncb3192. Epub 2015 Jun 22. Nat Cell Biol. 2015. PMID: 26098576 Free PMC article. Retracted.

3

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD. Selleck EM, et al. mBio. 2015 Sep 8;6(5):e01157-15. doi: 10.1128/mBio.01157-15. mBio. 2015. PMID: 26350966 Free PMC article.

4

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.

Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW. Redmann V, et al. Sci Rep. 2016 Mar 18;6:23326. doi: 10.1038/srep23326. Sci Rep. 2016. PMID: 26987296 Free PMC article.

5

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.

Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR. Martinez J, et al. Among authors: orchard r. Nature. 2016 May 5;533(7601):115-9. doi: 10.1038/nature17950. Epub 2016 Apr 20. Nature. 2016. PMID: 27096368 Free PMC article. Retracted.

6

Discovery of a proteinaceous cellular receptor for a norovirus.

Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW. Orchard RC, et al. Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18. Science. 2016. PMID: 27540007 Free PMC article.

7

Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.

Martinez J, Cunha LD, Park S, Yang M, Lu Q, Orchard R, Li QZ, Yan M, Janke L, Guy C, Linkermann A, Virgin HW, Green DR. Martinez J, et al. Among authors: orchard r. Nature. 2016 Nov 3;539(7627):124. doi: 10.1038/nature19837. Epub 2016 Sep 28. Nature. 2016. PMID: 27680703 No abstract available.

8

Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine.

Lee S, Wilen CB, Orvedahl A, McCune BT, Kim KW, Orchard RC, Peterson ST, Nice TJ, Baldridge MT, Virgin HW. Lee S, et al. Cell Host Microbe. 2017 Oct 11;22(4):449-459.e4. doi: 10.1016/j.chom.2017.08.021. Epub 2017 Sep 28. Cell Host Microbe. 2017. PMID: 28966054 Free PMC article.

9

Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Wilen CB, et al. Among authors: orchard rc. Science. 2018 Apr 13;360(6385):204-208. doi: 10.1126/science.aar3799. Science. 2018. PMID: 29650672 Free PMC article.

10

Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection.

Orchard RC, Wilen CB, Virgin HW. Orchard RC, et al. Nat Microbiol. 2018 Oct;3(10):1109-1114. doi: 10.1038/s41564-018-0221-8. Epub 2018 Aug 20. Nat Microbiol. 2018. PMID: 30127493 Free PMC article.

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