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Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis.
Ortega-Gonzalez P, Taylor G, Jangra RK, Tenorio R, Fernandez de Castro I, Mainou BA, Orchard RC, Wilen CB, Brigleb PH, Sojati J, Chandran K, Sachse M, Risco C, Dermody TS. Ortega-Gonzalez P, et al. Among authors: orchard rc. PLoS Pathog. 2022 Mar 9;18(3):e1010322. doi: 10.1371/journal.ppat.1010322. eCollection 2022 Mar. PLoS Pathog. 2022. PMID: 35263388 Free PMC article.
Discovery of a proteinaceous cellular receptor for a norovirus.
Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW. Orchard RC, et al. Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18. Science. 2016. PMID: 27540007 Free PMC article.
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.
Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S. Biering SB, et al. Among authors: orchard rc. Cell Host Microbe. 2017 Jul 12;22(1):74-85.e7. doi: 10.1016/j.chom.2017.06.005. Epub 2017 Jun 29. Cell Host Microbe. 2017. PMID: 28669671 Free PMC article.
Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.
Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH. Nelson CA, et al. Among authors: orchard rc. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9201-E9210. doi: 10.1073/pnas.1805797115. Epub 2018 Sep 7. Proc Natl Acad Sci U S A. 2018. PMID: 30194229 Free PMC article.
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.
Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. Lee S, et al. Among authors: orchard rc. Cell Host Microbe. 2019 Jun 12;25(6):845-857.e5. doi: 10.1016/j.chom.2019.04.005. Epub 2019 May 23. Cell Host Microbe. 2019. PMID: 31130511 Free PMC article.
CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus.
Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT, Wilen CB. Graziano VR, et al. Among authors: orchard rc. PLoS Pathog. 2020 Apr 6;16(4):e1008242. doi: 10.1371/journal.ppat.1008242. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32251490 Free PMC article.
49 results