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1998 18
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5,170 results

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Page 1
The hypocretin (orexin) system: from a neural circuitry perspective.
Li SB, de Lecea L. Li SB, et al. Neuropharmacology. 2020 May 1;167:107993. doi: 10.1016/j.neuropharm.2020.107993. Epub 2020 Feb 6. Neuropharmacology. 2020. PMID: 32135427 Review.
Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region known to orchestrate diverse functions including sleep, reward processing, food intake, thermogenesis, and mood. Since the hypocretins/orexins were discovered m …
Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region known to orchestrate diverse funct …
Hypocretin/orexin, sleep and narcolepsy.
Hungs M, Mignot E. Hungs M, et al. Bioessays. 2001 May;23(5):397-408. doi: 10.1002/bies.1058. Bioessays. 2001. PMID: 11340621 Review.
Hypocretin-1 and -2 (also called orexin-A and -B) are newly discovered neuropeptides processed from a common precursor, preprohypocretin. ...The role of the hypocretin system in normal sleep regulation is more uncertain. We believe hypocretin cells dri …
Hypocretin-1 and -2 (also called orexin-A and -B) are newly discovered neuropeptides processed from a common precursor, prepro …
Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors.
Hopf FW. Hopf FW. Neuropharmacology. 2020 May 15;168:108013. doi: 10.1016/j.neuropharm.2020.108013. Epub 2020 Feb 15. Neuropharmacology. 2020. PMID: 32092435 Free article. Review.
The neuropeptide hypocretin/orexin plays a broad and important role in physiological functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and homeostatic regulation. A number of recent reviews addressing the importance of orexin …
The neuropeptide hypocretin/orexin plays a broad and important role in physiological functions ranging from addiction, stress, …
Hypocretin/orexin disturbances in neurological disorders.
Fronczek R, Baumann CR, Lammers GJ, Bassetti CL, Overeem S. Fronczek R, et al. Sleep Med Rev. 2009 Feb;13(1):9-22. doi: 10.1016/j.smrv.2008.05.002. Epub 2008 Sep 25. Sleep Med Rev. 2009. PMID: 18819824 Review.
The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. ...In this paper we first review the current methods to measure the integrity of the hypocretin system in human patients. The most widely used techniq …
The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. ...In this paper …
Hypocretin/orexin and narcolepsy: new basic and clinical insights.
Nishino S, Okuro M, Kotorii N, Anegawa E, Ishimaru Y, Matsumura M, Kanbayashi T. Nishino S, et al. Acta Physiol (Oxf). 2010 Mar;198(3):209-22. doi: 10.1111/j.1748-1716.2009.02012.x. Epub 2009 Jun 25. Acta Physiol (Oxf). 2010. PMID: 19555382 Free PMC article. Review.
The major pathophysiology of human narcolepsy has been recently discovered based on the discovery of narcolepsy genes in animals; the genes involved in the pathology of the hypocretin/orexin ligand and its receptor. Mutations in hypocretin-related genes are r …
The major pathophysiology of human narcolepsy has been recently discovered based on the discovery of narcolepsy genes in animals; the genes …
Hypocretin/orexin and energy expenditure.
Teske JA, Billington CJ, Kotz CM. Teske JA, et al. Acta Physiol (Oxf). 2010 Mar;198(3):303-12. doi: 10.1111/j.1748-1716.2010.02075.x. Epub 2010 Jan 12. Acta Physiol (Oxf). 2010. PMID: 20070282 Review.
The hypocretins or orexins are endogenous neuropeptides synthesized in discrete lateral, perifornical and dorsal hypothalamic neurones. ...Thus far data suggest that hypocretin-1 has a more robust stimulatory effect relative to hypocretin-2. Furthermor …
The hypocretins or orexins are endogenous neuropeptides synthesized in discrete lateral, perifornical and dorsal hypothalamic …
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Sakurai T, et al. Cell. 1998 Feb 20;92(4):573-85. doi: 10.1016/s0092-8674(00)80949-6. Cell. 1998. PMID: 9491897 Free article.
We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural si …
We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two close …
Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy.
Overeem S, Scammell TE, Lammers GJ. Overeem S, et al. Curr Opin Neurol. 2002 Dec;15(6):739-45. doi: 10.1097/01.wco.0000044800.53746.5a. Curr Opin Neurol. 2002. PMID: 12447114 Review.
The discovery that the majority of human patients lack the hypothalamic neuropeptide hypocretin-1 has initiated a large body of new research. RECENT FINDINGS: Several studies on cerebrospinal fluid hypocretin-1 levels in narcolepsy and in various other sleep disorde …
The discovery that the majority of human patients lack the hypothalamic neuropeptide hypocretin-1 has initiated a large body of new r …
Reactive and predictive homeostasis: Roles of orexin/hypocretin neurons.
Burdakov D. Burdakov D. Neuropharmacology. 2019 Aug;154:61-67. doi: 10.1016/j.neuropharm.2018.10.024. Epub 2018 Oct 19. Neuropharmacology. 2019. PMID: 30347195 Review.
Here a model is proposed where the brain-wide-projecting, non-neuroendocrine, neurons of the hypothalamus, exemplified by orexin/hypocretin neurons, function as "brain government" systems that convert integrated internal and external information into reactive and pr …
Here a model is proposed where the brain-wide-projecting, non-neuroendocrine, neurons of the hypothalamus, exemplified by orexin/h …
Detection of reduced orexin-A/hypocretin-1 and its fragments by orexin-A "gold-standard" radioimmunoassay.
Kukkonen JP, Turunen PM, Rinne MK. Kukkonen JP, et al. Sleep Med. 2025 Jul;131:106505. doi: 10.1016/j.sleep.2025.106505. Epub 2025 Apr 10. Sleep Med. 2025. PMID: 40250157 Free article.
RESULTS: Our synthetic orexin-A bound correspondingly to the orexin-A standard included in the kit while orexin-B did not bind even at 10000-fold higher concentrations. Reduction of the disulfide bridges in orexin-A (giving orexin-A(-SS)) decrea …
RESULTS: Our synthetic orexin-A bound correspondingly to the orexin-A standard included in the kit while orexin-B did n …
5,170 results