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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.
Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA. Orimo A, et al. Cell. 2005 May 6;121(3):335-48. doi: 10.1016/j.cell.2005.02.034. Cell. 2005. PMID: 15882617
Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood. Using a coimplantation tumor xenograft model, we demonstrate that carcinoma-associated f …
Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these c …
Emerging roles of the tumor-associated stroma in promoting tumor metastasis.
Horimoto Y, Polanska UM, Takahashi Y, Orimo A. Horimoto Y, et al. Among authors: orimo a. Cell Adh Migr. 2012 May-Jun;6(3):193-202. doi: 10.4161/cam.20631. Epub 2012 May 1. Cell Adh Migr. 2012. PMID: 22568980 Free PMC article. Review.
It has long been accepted that alterations within carcinoma cells mediate metastasis in a cell-autonomous fashion. Recent studies have, however, suggested an additional notion that cancer cells instigate local and systemic changes in the tumor microenvironment and contribu …
It has long been accepted that alterations within carcinoma cells mediate metastasis in a cell-autonomous fashion. Recent studies hav …
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.
Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, Onder TT, Wang ZC, Richardson AL, Weinberg RA, Orimo A. Kojima Y, et al. Among authors: orimo a. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20009-14. doi: 10.1073/pnas.1013805107. Epub 2010 Nov 1. Proc Natl Acad Sci U S A. 2010. PMID: 21041659 Free PMC article.
Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast carcinomas, include a large number of myofibroblasts, a hallmark of activated fibroblasts. ...Using a coimplantation breast tumor xenograft model, we show that resident …
Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast carcinomas, include a large number of myofi …
The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.
Mezawa Y, Orimo A. Mezawa Y, et al. Among authors: orimo a. Cell Tissue Res. 2016 Sep;365(3):675-89. doi: 10.1007/s00441-016-2471-1. Epub 2016 Aug 10. Cell Tissue Res. 2016. PMID: 27506216 Review.
Carcinoma-associated fibroblasts (CAFs) constitute a substantial proportion of the non-neoplastic mesenchymal cell compartment in various human tumors. ...These fibroblasts have a major influence on the hallmarks of carcinoma and promote tumor malignancy through the …
Carcinoma-associated fibroblasts (CAFs) constitute a substantial proportion of the non-neoplastic mesenchymal cell compartment in var …
Heterogeneity of stromal fibroblasts in tumors.
Orimo A, Weinberg RA. Orimo A, et al. Cancer Biol Ther. 2007 Apr;6(4):618-9. doi: 10.4161/cbt.6.4.4255. Cancer Biol Ther. 2007. PMID: 18027438 No abstract available.
Stromal fibroblasts in cancer: a novel tumor-promoting cell type.
Orimo A, Weinberg RA. Orimo A, et al. Cell Cycle. 2006 Aug;5(15):1597-601. doi: 10.4161/cc.5.15.3112. Epub 2006 Aug 1. Cell Cycle. 2006. PMID: 16880743 Review.
Tumors are highly complex tissues composed of neoplastic cells and, in the case of carcinomas, stromal cell compartments containing a variety of mesenchymal cells, notably fibroblasts, myofibroblasts, endothelial cells, pericytes, and a variety of inflammatory cells …
Tumors are highly complex tissues composed of neoplastic cells and, in the case of carcinomas, stromal cell compartments containing a
Transforming growth factor-β: guardian of catabolic metabolism in carcinoma-associated fibroblasts.
Khan HY, Orimo A. Khan HY, et al. Among authors: orimo a. Cell Cycle. 2012 Dec 1;11(23):4302-3. doi: 10.4161/cc.22811. Epub 2012 Nov 16. Cell Cycle. 2012. PMID: 23159856 Free PMC article. No abstract available.
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.
Shimoda M, Mellody KT, Orimo A. Shimoda M, et al. Among authors: orimo a. Semin Cell Dev Biol. 2010 Feb;21(1):19-25. doi: 10.1016/j.semcdb.2009.10.002. Epub 2009 Oct 24. Semin Cell Dev Biol. 2010. PMID: 19857592 Free PMC article. Review.
Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts.
Polanska UM, Acar A, Orimo A. Polanska UM, et al. Among authors: orimo a. J Vis Exp. 2011 Oct 25;(56):e3201. doi: 10.3791/3201. J Vis Exp. 2011. PMID: 22064505 Free PMC article.
Carcinomas are complex tissues comprised of neoplastic cells and a non-cancerous compartment referred to as the 'stroma'. The stroma consists of extracellular matrix (ECM) and a variety of mesenchymal cells, including fibroblasts, myofibroblasts, endothelial cells, …
Carcinomas are complex tissues comprised of neoplastic cells and a non-cancerous compartment referred to as the 'stroma'. The stroma …
Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.
Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A. Matsumura Y, et al. Among authors: orimo a. Life Sci Alliance. 2019 Jul 22;2(4):e201900425. doi: 10.26508/lsa.201900425. Print 2019 Aug. Life Sci Alliance. 2019. PMID: 31331982 Free PMC article.
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