Orkin SH - Search Results

1

DNA methylation in adult stem cells: new insights into self-renewal.

Trowbridge JJ, Orkin SH. Trowbridge JJ, et al. Among authors: orkin sh. Epigenetics. 2010 Apr;5(3):189-93. doi: 10.4161/epi.5.3.11374. Epub 2010 Apr 1. Epigenetics. 2010. PMID: 20364115

2

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.

Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Mikkola HK, et al. Among authors: orkin sh. Nature. 2003 Jan 30;421(6922):547-51. doi: 10.1038/nature01345. Epub 2003 Jan 19. Nature. 2003. PMID: 12540851

3

Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.

Wang J, Levasseur DN, Orkin SH. Wang J, et al. Among authors: orkin sh. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6326-31. doi: 10.1073/pnas.0802288105. Epub 2008 Apr 24. Proc Natl Acad Sci U S A. 2008. PMID: 18436640 Free PMC article.

4

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.

Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. Hu G, et al. Among authors: orkin sh. Genes Dev. 2009 Apr 1;23(7):837-48. doi: 10.1101/gad.1769609. Genes Dev. 2009. PMID: 19339689 Free PMC article.

5

DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.

Trowbridge JJ, Snow JW, Kim J, Orkin SH. Trowbridge JJ, et al. Among authors: orkin sh. Cell Stem Cell. 2009 Oct 2;5(4):442-9. doi: 10.1016/j.stem.2009.08.016. Cell Stem Cell. 2009. PMID: 19796624 Free PMC article.

6

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Shen X, et al. Among authors: orkin sh. Cell. 2009 Dec 24;139(7):1303-14. doi: 10.1016/j.cell.2009.12.003. Cell. 2009. PMID: 20064376 Free PMC article.

7

Epigenetic memory in induced pluripotent stem cells.

Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ. Kim K, et al. Among authors: orkin sh. Nature. 2010 Sep 16;467(7313):285-90. doi: 10.1038/nature09342. Nature. 2010. PMID: 20644535 Free PMC article.

8

A single cis element maintains repression of the key developmental regulator Gata2.

Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Snow JW, et al. Among authors: orkin sh. PLoS Genet. 2010 Sep 9;6(9):e1001103. doi: 10.1371/journal.pgen.1001103. PLoS Genet. 2010. PMID: 20838598 Free PMC article.

9

Context-dependent function of "GATA switch" sites in vivo.

Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Snow JW, et al. Among authors: orkin sh. Blood. 2011 May 5;117(18):4769-72. doi: 10.1182/blood-2010-10-313031. Epub 2011 Mar 11. Blood. 2011. PMID: 21398579 Free PMC article.

10

Dnmt3a silences hematopoietic stem cell self-renewal.

Trowbridge JJ, Orkin SH. Trowbridge JJ, et al. Among authors: orkin sh. Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043. Nat Genet. 2011. PMID: 22200773

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