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Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.

Orlando BJ, Malkowski MG. Orlando BJ, et al. J Biol Chem. 2016 Jul 15;291(29):15069-81. doi: 10.1074/jbc.M116.725713. Epub 2016 May 20. J Biol Chem. 2016. PMID: 27226593 Free PMC article.

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Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.

Dong L, Yuan C, Orlando BJ, Malkowski MG, Smith WL. Dong L, et al. Among authors: orlando bj. J Biol Chem. 2016 Dec 2;291(49):25641-25655. doi: 10.1074/jbc.M116.757310. Epub 2016 Oct 18. J Biol Chem. 2016. PMID: 27756840 Free PMC article.

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Crystal structure of rofecoxib bound to human cyclooxygenase-2.

Orlando BJ, Malkowski MG. Orlando BJ, et al. Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):772-776. doi: 10.1107/S2053230X16014230. Epub 2016 Sep 22. Acta Crystallogr F Struct Biol Commun. 2016. PMID: 27710942 Free PMC article.

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Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.

Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. Lucido MJ, et al. Among authors: orlando bj. Biochemistry. 2016 Mar 1;55(8):1226-38. doi: 10.1021/acs.biochem.5b01378. Epub 2016 Feb 19. Biochemistry. 2016. PMID: 26859324 Free PMC article.

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Pulsed Dipolar Spectroscopy Reveals That Tyrosyl Radicals Are Generated in Both Monomers of the Cyclooxygenase-2 Dimer.

Orlando BJ, Borbat PP, Georgieva ER, Freed JH, Malkowski MG. Orlando BJ, et al. Biochemistry. 2015 Dec 22;54(50):7309-12. doi: 10.1021/acs.biochem.5b00979. Epub 2015 Dec 7. Biochemistry. 2015. PMID: 26636181 Free PMC article.

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The structure of ibuprofen bound to cyclooxygenase-2.

Orlando BJ, Lucido MJ, Malkowski MG. Orlando BJ, et al. J Struct Biol. 2015 Jan;189(1):62-6. doi: 10.1016/j.jsb.2014.11.005. Epub 2014 Nov 25. J Struct Biol. 2015. PMID: 25463020 Free PMC article.

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Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove.

Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG. Vecchio AJ, et al. Among authors: orlando bj. J Biol Chem. 2012 Jul 13;287(29):24619-30. doi: 10.1074/jbc.M112.372243. Epub 2012 May 25. J Biol Chem. 2012. PMID: 22637474 Free PMC article.

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Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs.

Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG. Orlando BJ, et al. Arch Biochem Biophys. 2014 Mar 15;546:33-40. doi: 10.1016/j.abb.2014.01.026. Epub 2014 Feb 3. Arch Biochem Biophys. 2014. PMID: 24503478 Free PMC article.

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Large protein organelles form a new iron sequestration system with high storage capacity.

Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA. Giessen TW, et al. Among authors: orlando bj. Elife. 2019 Jul 8;8:e46070. doi: 10.7554/eLife.46070. Elife. 2019. PMID: 31282860 Free PMC article.

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X-ray and cryo-EM structures of the mitochondrial calcium uniporter.

Fan C, Fan M, Orlando BJ, Fastman NM, Zhang J, Xu Y, Chambers MG, Xu X, Perry K, Liao M, Feng L. Fan C, et al. Among authors: orlando bj. Nature. 2018 Jul;559(7715):575-579. doi: 10.1038/s41586-018-0330-9. Epub 2018 Jul 11. Nature. 2018. PMID: 29995856 Free PMC article.

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