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Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Tripodi F, Pagliarin R, Fumagalli G, Bigi A, Fusi P, Orsini F, Frattini M, Coccetti P. Tripodi F, et al. Among authors: Orsini F. J Med Chem. 2012 Mar 8;55(5):2112-24. doi: 10.1021/jm201344a. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22329561
Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae.
Coccetti P, Montano G, Lombardo A, Tripodi F, Orsini F, Pagliarin R. Coccetti P, et al. Among authors: Orsini F. Bioorg Med Chem Lett. 2010 May 1;20(9):2780-4. doi: 10.1016/j.bmcl.2010.03.066. Epub 2010 Mar 17. Bioorg Med Chem Lett. 2010. PMID: 20363626
A series of Z and E combretastatin A-4 analogs bearing different substituents (OH, F, NO(2), NH(2), B(OH)(2)) in the 3' position were synthesized. ...
A series of Z and E combretastatin A-4 analogs bearing different substituents (OH, F, NO(2), NH(2), B(OH)(2)) in the 3' position were …
A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer.
Valtorta S, Nicolini G, Tripodi F, Meregalli C, Cavaletti G, Avezza F, Crippa L, Bertoli G, Sanvito F, Fusi P, Pagliarin R, Orsini F, Moresco RM, Coccetti P. Valtorta S, et al. Among authors: Orsini F. Invest New Drugs. 2014 Dec;32(6):1123-33. doi: 10.1007/s10637-014-0148-8. Epub 2014 Aug 19. Invest New Drugs. 2014. PMID: 25134489
Arrest of tumor growth and relapse after drug suspension are parallel to modification in glucose demand as shown by PET studies with [(18)F] FDG. ...
Arrest of tumor growth and relapse after drug suspension are parallel to modification in glucose demand as shown by PET studies with [(18) …
Insect pest control agents: Novel chiral butanoate esters (juvenogens).
Wimmer Z, Floro AJ, Zarevúcka M, Wimmerová M, Sello G, Orsini F. Wimmer Z, et al. Among authors: Orsini F. Bioorg Med Chem. 2007 Sep 15;15(18):6037-42. doi: 10.1016/j.bmc.2007.06.043. Epub 2007 Jun 27. Bioorg Med Chem. 2007. PMID: 17614289
The enantiomeric purity of the products was determined by chiral HPLC analysis, and their absolute configuration was assigned on the basis of analyzing the (1)H and (19)F NMR spectra of their diastereoisomeric Mosher acid (3,3,3-trifluoromethyl-2-methoxy-2-phenylpropanoic acid) esters....
The enantiomeric purity of the products was determined by chiral HPLC analysis, and their absolute configuration was assigned on the basis o …
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