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Pharmacokinetics, Pharmacodynamics, Immunogenicity, Safety, and Tolerability of JNJ-61178104, a Novel Tumor Necrosis Factor-Alpha and Interleukin-17A Bispecific Antibody, in Healthy Subjects.
Akpalu DE, Frederick B, Nnane IP, Yao Z, Shen F, Ort T, Fink D, Dogmanits S, Raible D, Sharma A, Xu Z. Akpalu DE, et al. Among authors: ort t. J Clin Pharmacol. 2019 Jul;59(7):968-978. doi: 10.1002/jcph.1393. Epub 2019 Feb 18. J Clin Pharmacol. 2019. PMID: 30776134 Clinical Trial.
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.
Sharma A, Menche J, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL. Sharma A, et al. Among authors: ort t. Hum Mol Genet. 2015 Jun 1;24(11):3005-20. doi: 10.1093/hmg/ddv001. Epub 2015 Jan 12. Hum Mol Genet. 2015. PMID: 25586491 Free PMC article.
TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.
Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, Myers TG, Wynn TA, Ramalingam TR. Badalyan V, et al. Among authors: ort t. J Allergy Clin Immunol. 2014 Oct;134(4):975-8.e5. doi: 10.1016/j.jaci.2014.05.019. Epub 2014 Jun 20. J Allergy Clin Immunol. 2014. PMID: 24954262 Free PMC article.
CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice.
Parlevliet ET, Schröder-van der Elst JP, Corssmit EP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H. Parlevliet ET, et al. Among authors: ort t. J Pharmacol Exp Ther. 2009 Jan;328(1):240-8. doi: 10.1124/jpet.108.144154. Epub 2008 Oct 10. J Pharmacol Exp Ther. 2009. PMID: 18849357
29 results