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Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.
Andreoli M, Persico M, Kumar A, Orteca N, Kumar V, Pepe A, Mahalingam S, Alegria AE, Petrella L, Sevciunaite L, Camperchioli A, Mariani M, Di Dato A, Novellino E, Scambia G, Malhotra SV, Ferlini C, Fattorusso C. Andreoli M, et al. Among authors: orteca n. J Med Chem. 2014 Oct 9;57(19):7916-32. doi: 10.1021/jm5009902. Epub 2014 Sep 26. J Med Chem. 2014. PMID: 25211704 Free PMC article.
New anticancer agents mimicking protein recognition motifs.
Persico M, Ramunno A, Maglio V, Franceschelli S, Esposito C, Carotenuto A, Brancaccio D, De Pasquale V, Pavone LM, Varra M, Orteca N, Novellino E, Fattorusso C. Persico M, et al. Among authors: orteca n. J Med Chem. 2013 Sep 12;56(17):6666-80. doi: 10.1021/jm400947b. Epub 2013 Aug 19. J Med Chem. 2013. PMID: 23879262
From Protein Communication to Drug Discovery.
Persico M, Di Dato A, Orteca N, Fattorusso C, Novellino E, Andreoli M, Ferlini C. Persico M, et al. Among authors: orteca n. Curr Top Med Chem. 2015;15(20):2019-31. doi: 10.2174/1568026615666150519102257. Curr Top Med Chem. 2015. PMID: 25986690 Review.
Correction to new anticancer agents mimicking protein recognition motifs.
Persico M, Ramunno A, Maglio V, Franceschelli S, Esposito C, Carotenuto A, Brancaccio D, De Pasquale V, Pavone LM, Varra M, Orteca N, Novellino E, Fattorusso C. Persico M, et al. Among authors: orteca n. J Med Chem. 2015 May 14;58(9):4088. doi: 10.1021/acs.jmedchem.5b00607. Epub 2015 Apr 30. J Med Chem. 2015. PMID: 25927290 No abstract available.
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Butini S, Campiani G, Franceschini S, Trotta F, Kumar V, Guarino E, Borrelli G, Fiorini I, Novellino E, Fattorusso C, Persico M, Orteca N, Sandager-Nielsen K, Jacobsen TA, Madsen K, Scheel-Kruger J, Gemma S. Butini S, et al. Among authors: orteca n. J Med Chem. 2010 Jun 24;53(12):4803-7. doi: 10.1021/jm100294b. J Med Chem. 2010. PMID: 20481570