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Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.
Shen Y, Connolly E, Aiello M, Zhou C, Chappa P, Song H, Tippitak P, Clark T, Cardenas M, Prokhnevska N, Mariniello A, Pagadala MS, Dhere VR, Rafiq S, Kesarwala AH, Orthwein A, Thomas SN, Khan MK, Brandon Dixon J, Lesinski GB, Lowe MC, Kissick H, Yu DS, Paulos CM, Schmitt NC, Buchwald ZS. Shen Y, et al. Among authors: orthwein a. Res Sq [Preprint]. 2024 Mar 6:rs.3.rs-3921977. doi: 10.21203/rs.3.rs-3921977/v1. Res Sq. 2024. PMID: 38496632 Free PMC article. Preprint.
The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.
Luo VM, Shen C, Worme S, Bhagrath A, Simo-Cheyou E, Findlay S, Hébert S, Wai Lam Poon W, Aryanpour Z, Zhang T, Zahedi RP, Boulais J, Buchwald ZS, Borchers CH, Côté JF, Kleinman CL, Mandl JN, Orthwein A. Luo VM, et al. Among authors: orthwein a. Mol Cell Biol. 2024 Jan;44(1):1-16. doi: 10.1080/10985549.2023.2290434. Epub 2024 Jan 29. Mol Cell Biol. 2024. PMID: 38270191
FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.
Pinedo-Carpio E, Dessapt J, Beneyton A, Sacre L, Bérubé MA, Villot R, Lavoie EG, Coulombe Y, Blondeau A, Boulais J, Malina A, Luo VM, Lazaratos AM, Côté JF, Mallette FA, Guarné A, Masson JY, Fradet-Turcotte A, Orthwein A. Pinedo-Carpio E, et al. Among authors: orthwein a. Sci Adv. 2023 Aug 9;9(32):eadf4082. doi: 10.1126/sciadv.adf4082. Epub 2023 Aug 9. Sci Adv. 2023. PMID: 37556550 Free PMC article.
B cell-specific knockout of AID protects against atherosclerosis.
Ebrahimian T, Dierick F, Ta V, Kotsiopriftis M, O'Connor Miranda J, Mann KK, Orthwein A, Lehoux S. Ebrahimian T, et al. Among authors: orthwein a. Sci Rep. 2023 May 30;13(1):8723. doi: 10.1038/s41598-023-35980-1. Sci Rep. 2023. PMID: 37253865 Free PMC article.
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.
Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A. Findlay S, et al. Among authors: orthwein a. Blood Adv. 2023 Jul 25;7(14):3485-3500. doi: 10.1182/bloodadvances.2022008345. Blood Adv. 2023. PMID: 36920785 Free PMC article.
EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.
Fooks K, Galicia-Vazquez G, Gife V, Schcolnik-Cabrera A, Nouhi Z, Poon WWL, Luo V, Rys RN, Aloyz R, Orthwein A, Johnson NA, Hulea L, Mercier FE. Fooks K, et al. Among authors: orthwein a. J Exp Clin Cancer Res. 2022 Dec 9;41(1):340. doi: 10.1186/s13046-022-02542-8. J Exp Clin Cancer Res. 2022. PMID: 36482393 Free PMC article.
Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability.
Simo Cheyou E, Boni J, Boulais J, Pinedo-Carpio E, Malina A, Sherill-Rofe D, Luo VM, Goncalves C, Bagci H, Maters A, Cuella-Martin R, Tabach Y, Del Rincon S, Côté JF, Rivera B, Orthwein A. Simo Cheyou E, et al. Among authors: orthwein a. PLoS Genet. 2022 Nov 14;18(11):e1010495. doi: 10.1371/journal.pgen.1010495. eCollection 2022 Nov. PLoS Genet. 2022. PMID: 36374936 Free PMC article.
Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair.
Sherill-Rofe D, Raban O, Findlay S, Rahat D, Unterman I, Samiei A, Yasmeen A, Kaiser Z, Kuasne H, Park M, Foulkes WD, Bloch I, Zick A, Gotlieb WH, Tabach Y, Orthwein A. Sherill-Rofe D, et al. Among authors: orthwein a. NAR Cancer. 2022 Apr 8;4(2):zcac013. doi: 10.1093/narcan/zcac013. eCollection 2022 Jun. NAR Cancer. 2022. PMID: 35399185 Free PMC article.
A decade of RAD51C and RAD51D germline variants in cancer.
Boni J, Idani A, Roca C, Feliubadaló L, Tomiak E, Weber E, Foulkes WD, Orthwein A, El Haffaf Z, Lazaro C, Rivera B. Boni J, et al. Among authors: orthwein a. Hum Mutat. 2022 Mar;43(3):285-298. doi: 10.1002/humu.24319. Epub 2021 Dec 30. Hum Mutat. 2022. PMID: 34923718 Review.
38 results