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A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.
Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, Mortensen HB, Pociot F, van Loo G, Størling J, Cardozo AK. Fukaya M, et al. Among authors: ortis f. Mol Endocrinol. 2016 Jan;30(1):48-61. doi: 10.1210/me.2015-1176. Epub 2015 Dec 10. Mol Endocrinol. 2016. PMID: 26652732 Free PMC article.
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J. Berchtold LA, et al. Among authors: ortis f. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E681-8. doi: 10.1073/pnas.1104384108. Epub 2011 Jun 24. Proc Natl Acad Sci U S A. 2011. PMID: 21705657 Free PMC article.
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.
Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M. Eizirik DL, et al. Among authors: ortis f. PLoS Genet. 2012;8(3):e1002552. doi: 10.1371/journal.pgen.1002552. Epub 2012 Mar 8. PLoS Genet. 2012. PMID: 22412385 Free PMC article.
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.
Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Ørntoft TF, Eizirik DL. Moore F, et al. Among authors: ortis f. J Biol Chem. 2011 Jan 14;286(2):929-41. doi: 10.1074/jbc.M110.162131. Epub 2010 Oct 27. J Biol Chem. 2011. PMID: 20980260 Free PMC article.
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