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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin G Jr, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, Graham RR. Gateva V, et al. Among authors: ortmann w. Nat Genet. 2009 Nov;41(11):1228-33. doi: 10.1038/ng.468. Epub 2009 Oct 18. Nat Genet. 2009. PMID: 19838195 Free PMC article.
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
Graham RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann WA, Koeuth T, González Escribano MF; Argentine and Spanish Collaborative Groups; Pons-Estel B, Petri M, Daly M, Gregersen PK, Martín J, Altshuler D, Behrens TW, Alarcón-Riquelme ME. Graham RR, et al. Among authors: ortmann wa. Nat Genet. 2006 May;38(5):550-5. doi: 10.1038/ng1782. Epub 2006 Apr 16. Nat Genet. 2006. PMID: 16642019
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
Taylor KE, Chung SA, Graham RR, Ortmann WA, Lee AT, Langefeld CD, Jacob CO, Kamboh MI, Alarcón-Riquelme ME, Tsao BP, Moser KL, Gaffney PM, Harley JB, Petri M, Manzi S, Gregersen PK, Behrens TW, Criswell LA. Taylor KE, et al. Among authors: ortmann wa. PLoS Genet. 2011 Feb;7(2):e1001311. doi: 10.1371/journal.pgen.1001311. Epub 2011 Feb 17. PLoS Genet. 2011. PMID: 21379322 Free PMC article.
Review of recent genome-wide association scans in lupus.
Graham RR, Hom G, Ortmann W, Behrens TW. Graham RR, et al. Among authors: ortmann w. J Intern Med. 2009 Jun;265(6):680-8. doi: 10.1111/j.1365-2796.2009.02096.x. J Intern Med. 2009. PMID: 19493061 Free article. Review.
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW. Hom G, et al. Among authors: ortmann w. N Engl J Med. 2008 Feb 28;358(9):900-9. doi: 10.1056/NEJMoa0707865. Epub 2008 Jan 20. N Engl J Med. 2008. PMID: 18204098 Free article.
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
Ferreira RC, Pan-Hammarström Q, Graham RR, Gateva V, Fontán G, Lee AT, Ortmann W, Urcelay E, Fernández-Arquero M, Núñez C, Jorgensen G, Ludviksson BR, Koskinen S, Haimila K, Clark HF, Klareskog L, Gregersen PK, Behrens TW, Hammarström L. Ferreira RC, et al. Among authors: ortmann w. Nat Genet. 2010 Sep;42(9):777-80. doi: 10.1038/ng.644. Epub 2010 Aug 8. Nat Genet. 2010. PMID: 20694011
The genetics of type I interferon in systemic lupus erythematosus.
Bronson PG, Chaivorapol C, Ortmann W, Behrens TW, Graham RR. Bronson PG, et al. Among authors: ortmann w. Curr Opin Immunol. 2012 Oct;24(5):530-7. doi: 10.1016/j.coi.2012.07.008. Epub 2012 Aug 10. Curr Opin Immunol. 2012. PMID: 22889593 Review.
Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.
Bronson PG, Chang D, Bhangale T, Seldin MF, Ortmann W, Ferreira RC, Urcelay E, Pereira LF, Martin J, Plebani A, Lougaris V, Friman V, Freiberger T, Litzman J, Thon V, Pan-Hammarström Q, Hammarström L, Graham RR, Behrens TW. Bronson PG, et al. Among authors: ortmann w. Nat Genet. 2016 Nov;48(11):1425-1429. doi: 10.1038/ng.3675. Epub 2016 Oct 10. Nat Genet. 2016. PMID: 27723758 Free PMC article.
60 results