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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. De Souza AT, et al. Among authors: orton tc. Nat Genet. 1995 Dec;11(4):447-9. doi: 10.1038/ng1295-447. Nat Genet. 1995. PMID: 7493029
Tissue-specific inactivation of murine M6P/IGF2R.
Wylie AA, Pulford DJ, McVie-Wylie AJ, Waterland RA, Evans HK, Chen YT, Nolan CM, Orton TC, Jirtle RL. Wylie AA, et al. Among authors: orton tc. Am J Pathol. 2003 Jan;162(1):321-8. doi: 10.1016/S0002-9440(10)63823-0. Am J Pathol. 2003. PMID: 12507915 Free PMC article.
Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.
De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL. De Souza AT, et al. Among authors: orton tc. Oncogene. 1995 May 4;10(9):1725-9. Oncogene. 1995. PMID: 7753549
Hepatocarcinogenic effect of vinyl carbamate in the C57Bl/10J strain mouse.
Wright JA, Marsden AM, Willets JM, Orton TC. Wright JA, et al. Among authors: orton tc. Toxicol Pathol. 1991;19(3):258-65. doi: 10.1177/019262339101900308. Toxicol Pathol. 1991. PMID: 1664139
Carcinogenicity of cyproterone acetate in the mouse.
Tucker MJ, Kalinowski AE, Orton TC. Tucker MJ, et al. Among authors: orton tc. Carcinogenesis. 1996 Jul;17(7):1473-6. doi: 10.1093/carcin/17.7.1473. Carcinogenesis. 1996. PMID: 8706251
Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone.
Orton TC, Doughty SE, Kalinowski AE, Lord PG, Wadsworth PF. Orton TC, et al. Carcinogenesis. 1996 May;17(5):973-81. doi: 10.1093/carcin/17.5.973. Carcinogenesis. 1996. PMID: 8640946
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
Lord PG, Hardaker KJ, Loughlin JM, Marsden AM, Orton TC. Lord PG, et al. Among authors: orton tc. Carcinogenesis. 1992 Aug;13(8):1383-7. doi: 10.1093/carcin/13.8.1383. Carcinogenesis. 1992. PMID: 1499088
Changes in protein and mRNA levels of growth factor/growth factor receptors in rat livers after administration of phenobarbitone or methylclofenapate.
Garcia-Allan C, Loughlin J, Orton T, Lord P. Garcia-Allan C, et al. Among authors: orton t. Arch Toxicol. 1997;71(7):409-15. doi: 10.1007/s002040050404. Arch Toxicol. 1997. PMID: 9209685
Phenobarbitone-induced liver response in wild type and in p53 deficient mice.
Gould S, Sidaway J, Sansom N, Betton G, Orton T. Gould S, et al. Among authors: orton t. Toxicol Lett. 2001 Jun 20;122(2):131-40. doi: 10.1016/s0378-4274(01)00349-6. Toxicol Lett. 2001. PMID: 11439219
Identification of phenobarbitone-modulated genes in mouse liver by differential display.
Garcia-Allan C, Lord PG, Loughlin JM, Orton TC, Sidaway JE. Garcia-Allan C, et al. Among authors: orton tc. J Biochem Mol Toxicol. 2000;14(2):65-72. doi: 10.1002/(sici)1099-0461(2000)14:2<65::aid-jbt1>3.0.co;2-#. J Biochem Mol Toxicol. 2000. PMID: 10630419
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