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Niemann-Pick type C: a disorder of cellular cholesterol trafficking.
Ory DS. Ory DS. Biochim Biophys Acta. 2000 Dec 15;1529(1-3):331-9. doi: 10.1016/s1388-1981(00)00158-x. Biochim Biophys Acta. 2000. PMID: 11111100 Review. No abstract available.
Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.
Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. Millard EE, et al. J Biol Chem. 2000 Dec 8;275(49):38445-51. doi: 10.1074/jbc.M003180200. J Biol Chem. 2000. PMID: 10964915
A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function.
Feng X, Novack DV, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, Teitelbaum SL. Feng X, et al. J Clin Invest. 2001 May;107(9):1137-44. doi: 10.1172/JCI12040. J Clin Invest. 2001. PMID: 11342577 Free PMC article.
Membrane topology of the murine fatty acid transport protein 1.
Lewis SE, Listenberger LL, Ory DS, Schaffer JE. Lewis SE, et al. J Biol Chem. 2001 Oct 5;276(40):37042-50. doi: 10.1074/jbc.M105556200. Epub 2001 Jul 24. J Biol Chem. 2001. PMID: 11470793
Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.
Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Frolov A, et al. J Biol Chem. 2001 Dec 7;276(49):46414-21. doi: 10.1074/jbc.M108099200. Epub 2001 Sep 24. J Biol Chem. 2001. PMID: 11571306
Oligomerization of the murine fatty acid transport protein 1.
Richards MR, Listenberger LL, Kelly AA, Lewis SE, Ory DS, Schaffer JE. Richards MR, et al. J Biol Chem. 2003 Mar 21;278(12):10477-83. doi: 10.1074/jbc.M212469200. Epub 2003 Jan 17. J Biol Chem. 2003. PMID: 12533547
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. Frolov A, et al. J Biol Chem. 2003 Jul 11;278(28):25517-25. doi: 10.1074/jbc.M302588200. Epub 2003 Apr 28. J Biol Chem. 2003. PMID: 12719428
The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.
Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS. Millard EE, et al. J Biol Chem. 2005 Aug 5;280(31):28581-90. doi: 10.1074/jbc.M414024200. Epub 2005 May 20. J Biol Chem. 2005. PMID: 15908696
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