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G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.
Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. Osborn O, et al. J Clin Invest. 2012 Jul;122(7):2444-53. doi: 10.1172/JCI61953. Epub 2012 Jun 1. J Clin Invest. 2012. PMID: 22653059 Free PMC article.
Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.
Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM. Lu M, et al. Among authors: osborn o. J Biol Chem. 2013 Apr 12;288(15):10722-35. doi: 10.1074/jbc.M112.443606. Epub 2013 Mar 1. J Biol Chem. 2013. PMID: 23457303 Free PMC article.
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. Suh JM, et al. Among authors: osborn o. Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16. Nature. 2014. PMID: 25043058 Free PMC article.
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice.
Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY. Morinaga H, et al. Among authors: osborn o. Diabetes. 2015 Apr;64(4):1120-30. doi: 10.2337/db14-1238. Epub 2014 Oct 14. Diabetes. 2015. PMID: 25315009 Free PMC article.
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