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Identification of insulin-responsive regions in the HMG-CoA reductase promoter.
Osborne AR, Pollock VV, Lagor WR, Ness GC. Osborne AR, et al. Biochem Biophys Res Commun. 2004 Jun 11;318(4):814-8. doi: 10.1016/j.bbrc.2004.04.105. Biochem Biophys Res Commun. 2004. PMID: 15147943
Technological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX.
Niesen MI, Osborne AR, Lagor WR, Zhang H, Kazemfar K, Ness GC, Blanck G. Niesen MI, et al. Among authors: osborne ar. Acta Biochim Biophys Sin (Shanghai). 2009 Mar;41(3):198-205. doi: 10.1093/abbs/gmp002. Acta Biochim Biophys Sin (Shanghai). 2009. PMID: 19280058
Oct-1 DNA binding activity unresponsive to retinoblastoma protein expression prevents MHC class II induction in a non-small cell lung carcinoma cell line.
Osborne AR, Zhang H, Blanck G. Osborne AR, et al. Mol Immunol. 2006 Feb;43(6):710-6. doi: 10.1016/j.molimm.2005.03.013. Epub 2005 Apr 14. Mol Immunol. 2006. PMID: 16360016
Activation of a methylated promoter mediated by a sequence-specific DNA-binding protein, RFX.
Niesen MI, Osborne AR, Yang H, Rastogi S, Chellappan S, Cheng JQ, Boss JM, Blanck G. Niesen MI, et al. Among authors: osborne ar. J Biol Chem. 2005 Nov 25;280(47):38914-22. doi: 10.1074/jbc.M504633200. Epub 2005 Sep 15. J Biol Chem. 2005. PMID: 16166088
Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter.
Osborne AR, Zhang H, Fejer G, Palubin KM, Niesen MI, Blanck G. Osborne AR, et al. J Biol Chem. 2004 Jul 9;279(28):28911-9. doi: 10.1074/jbc.M403118200. Epub 2004 Apr 22. J Biol Chem. 2004. PMID: 15105429
Retinoblastoma protein expression facilitates chromatin remodeling at the HLA-DRA promoter.
Osborne A, Tschickardt M, Blanck G. Osborne A, et al. Nucleic Acids Res. 1997 Dec 15;25(24):5095-102. doi: 10.1093/nar/25.24.5095. Nucleic Acids Res. 1997. PMID: 9396821 Free PMC article.
Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation.
Osborne A, Zhang H, Yang WM, Seto E, Blanck G. Osborne A, et al. Mol Cell Biol. 2001 Oct;21(19):6495-506. doi: 10.1128/mcb.21.19.6495-6506.2001. Mol Cell Biol. 2001. PMID: 11533238 Free PMC article.
A direct mechanistic link between growth control and a tumor cell immune function: increased interleukin-8 secretion accounts for elimination of Oct-1 antisense transformants from scid mice.
Palubin KM, Goodwin BL, Niesen MI, Le EA, Osborne AR, Blanck G. Palubin KM, et al. Among authors: osborne ar. Anticancer Res. 2006 May-Jun;26(3A):1733-8. Anticancer Res. 2006. PMID: 16827100
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative.
Bennett C, Crawford F, Osborne A, Diaz P, Hoyne J, Lopez R, Roques P, Duara R, Rossor M, Mullan M. Bennett C, et al. Among authors: osborne a. Am J Med Genet. 1995 Feb 27;60(1):1-6. doi: 10.1002/ajmg.1320600102. Am J Med Genet. 1995. PMID: 7485228
Dopamine DRD2/Cys311 is not associated with chronic schizophrenia.
Crawford F, Hoyne J, Cai X, Osborne A, Poston D, Zaglul J, Dajani N, Walsh S, Bradley R, Solomon R, Mullan M. Crawford F, et al. Among authors: osborne a. Am J Med Genet. 1996 Sep 20;67(5):483-4. doi: 10.1002/(SICI)1096-8628(19960920)67:5<483::AID-AJMG8>3.0.CO;2-L. Am J Med Genet. 1996. PMID: 8886166
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