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23 results
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Differential selectivity in carbamazepine-induced inactivation of cytochrome P450 enzymes in rat and human liver.
Masubuchi Y, Nakano T, Ose A, Horie T. Masubuchi Y, et al. Among authors: ose a. Arch Toxicol. 2001 Nov;75(9):538-43. doi: 10.1007/s002040100270. Arch Toxicol. 2001. PMID: 11760814
Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine.
Masubuchi Y, Ose A, Horie T. Masubuchi Y, et al. Among authors: ose a. Drug Metab Dispos. 2002 Oct;30(10):1143-8. doi: 10.1124/dmd.30.10.1143. Drug Metab Dispos. 2002. PMID: 12228192
Mechanism-based inactivation of CYP2C11 by diclofenac.
Masubuchi Y, Ose A, Horie T. Masubuchi Y, et al. Among authors: ose a. Drug Metab Dispos. 2001 Sep;29(9):1190-5. Drug Metab Dispos. 2001. PMID: 11502726
P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
Ose A, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Fujita T, Yamamoto A, Sugiyama Y. Ose A, et al. Drug Metab Dispos. 2008 Feb;36(2):427-34. doi: 10.1124/dmd.107.018556. Epub 2007 Nov 26. Drug Metab Dispos. 2008. PMID: 18039806
Automated extraction of information on chemical-P-glycoprotein interactions from the literature.
Yoshida S, Yamashita F, Ose A, Maeda K, Sugiyama Y, Hashida M. Yoshida S, et al. Among authors: ose a. J Chem Inf Model. 2013 Oct 28;53(10):2506-10. doi: 10.1021/ci4003188. Epub 2013 Sep 24. J Chem Inf Model. 2013. PMID: 24010770
Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.
Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y. Ose A, et al. Drug Metab Dispos. 2010 Jan;38(1):168-76. doi: 10.1124/dmd.109.029454. Drug Metab Dispos. 2010. PMID: 19833843
Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.
Ito M, Kusuhara H, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y. Ito M, et al. Among authors: ose a. AAPS J. 2017 Jan;19(1):286-297. doi: 10.1208/s12248-016-9992-0. Epub 2016 Oct 31. AAPS J. 2017. PMID: 27800573
Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).
Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y. Ose A, et al. Drug Metab Dispos. 2009 Feb;37(2):315-21. doi: 10.1124/dmd.108.024018. Epub 2008 Nov 24. Drug Metab Dispos. 2009. PMID: 19029202
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
Enokizono J, Kusuhara H, Ose A, Schinkel AH, Sugiyama Y. Enokizono J, et al. Among authors: ose a. Drug Metab Dispos. 2008 Jun;36(6):995-1002. doi: 10.1124/dmd.107.019257. Epub 2008 Mar 5. Drug Metab Dispos. 2008. PMID: 18322075
Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.
Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y. Ito S, et al. Among authors: ose a. J Pharm Sci. 2013 Sep;102(9):3294-301. doi: 10.1002/jps.23599. Epub 2013 May 27. J Pharm Sci. 2013. PMID: 23712676
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