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Page 1
Topoisomerase II and the etiology of chromosomal translocations.
Felix CA, Kolaris CP, Osheroff N. Felix CA, et al. Among authors: osheroff n. DNA Repair (Amst). 2006 Sep 8;5(9-10):1093-108. doi: 10.1016/j.dnarep.2006.05.031. Epub 2006 Jul 20. DNA Repair (Amst). 2006. PMID: 16857431 Review.
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.
Lovett BD, Lo Nigro L, Rappaport EF, Blair IA, Osheroff N, Zheng N, Megonigal MD, Williams WR, Nowell PC, Felix CA. Lovett BD, et al. Among authors: osheroff n. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9802-7. doi: 10.1073/pnas.171309898. Epub 2001 Aug 7. Proc Natl Acad Sci U S A. 2001. PMID: 11493704 Free PMC article.
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA. Slater DJ, et al. Among authors: osheroff n. Oncogene. 2002 Jul 11;21(30):4706-14. doi: 10.1038/sj.onc.1205572. Oncogene. 2002. PMID: 12096348
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD, Carroll M, Liu M, Osheroff N, Cheung NK, Slater DJ, Ried T, Knutsen T, Blair IA, Felix CA. Whitmarsh RJ, et al. Among authors: osheroff n. Oncogene. 2003 Nov 20;22(52):8448-59. doi: 10.1038/sj.onc.1207052. Oncogene. 2003. PMID: 14627986
1,4-Benzoquinone is a topoisomerase II poison.
Lindsey RH Jr, Bromberg KD, Felix CA, Osheroff N. Lindsey RH Jr, et al. Among authors: osheroff n. Biochemistry. 2004 Jun 15;43(23):7563-74. doi: 10.1021/bi049756r. Biochemistry. 2004. PMID: 15182198
DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon E, Fenaux P, Grimwade D. Mistry AR, et al. Among authors: osheroff n. N Engl J Med. 2005 Apr 14;352(15):1529-38. doi: 10.1056/NEJMoa042715. N Engl J Med. 2005. PMID: 15829534 Free article.
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
Hasan SK, Mays AN, Ottone T, Ledda A, La Nasa G, Cattaneo C, Borlenghi E, Melillo L, Montefusco E, Cervera J, Stephen C, Satchi G, Lennard A, Libura M, Byl JA, Osheroff N, Amadori S, Felix CA, Voso MT, Sperr WR, Esteve J, Sanz MA, Grimwade D, Lo-Coco F. Hasan SK, et al. Among authors: osheroff n. Blood. 2008 Oct 15;112(8):3383-90. doi: 10.1182/blood-2007-10-115600. Epub 2008 Jul 23. Blood. 2008. PMID: 18650449 Free PMC article.
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
Mays AN, Osheroff N, Xiao Y, Wiemels JL, Felix CA, Byl JA, Saravanamuttu K, Peniket A, Corser R, Chang C, Hoyle C, Parker AN, Hasan SK, Lo-Coco F, Solomon E, Grimwade D. Mays AN, et al. Among authors: osheroff n. Blood. 2010 Jan 14;115(2):326-30. doi: 10.1182/blood-2009-07-235051. Epub 2009 Nov 2. Blood. 2010. PMID: 19884644 Free PMC article.
242 results