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The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.
Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB Jr, Zabner J, Welsh MJ, Stoltz DA. Ostedgaard LS, et al. Sci Transl Med. 2011 Mar 16;3(74):74ra24. doi: 10.1126/scitranslmed.3001868. Sci Transl Med. 2011. PMID: 21411740 Free PMC article.
Processing and function of CFTR-DeltaF508 are species-dependent.
Ostedgaard LS, Rogers CS, Dong Q, Randak CO, Vermeer DW, Rokhlina T, Karp PH, Welsh MJ. Ostedgaard LS, et al. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15370-5. doi: 10.1073/pnas.0706974104. Epub 2007 Sep 14. Proc Natl Acad Sci U S A. 2007. PMID: 17873061 Free PMC article.
The porcine lung as a potential model for cystic fibrosis.
Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB Jr, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. Rogers CS, et al. Among authors: ostedgaard ls. Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L240-63. doi: 10.1152/ajplung.90203.2008. Epub 2008 May 16. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18487356 Free PMC article. Review.
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Rogers CS, et al. Among authors: ostedgaard ls. Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600. Science. 2008. PMID: 18818360 Free PMC article.
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA 4th, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ. Stoltz DA, et al. Among authors: ostedgaard ls. Sci Transl Med. 2010 Apr 28;2(29):29ra31. doi: 10.1126/scitranslmed.3000928. Sci Transl Med. 2010. PMID: 20427821 Free PMC article.
59 results