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The following term was not found in PubMed: Osterwander
Page 1
Did you mean osterwalder geneswitch drosophila (2 results)?
The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila.
Zappia MP, Damschroder D, Westacott A, Wessells RJ, Frolov MV. Zappia MP, et al. G3 (Bethesda). 2024 May 7;14(5):jkae039. doi: 10.1093/g3journal/jkae039. G3 (Bethesda). 2024. PMID: 38409337 Free PMC article.
Robust genetic systems to control the expression of transgenes in a spatial and temporal manner are a valuable asset for researchers. The GeneSwitch system induced by the drug RU486 has gained widespread use in the Drosophila community. ...Here, we characterized the …
Robust genetic systems to control the expression of transgenes in a spatial and temporal manner are a valuable asset for researchers. The …
Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase.
Andjelković A, Kemppainen KK, Jacobs HT. Andjelković A, et al. G3 (Bethesda). 2016 Sep 8;6(9):2839-46. doi: 10.1534/g3.116.030882. G3 (Bethesda). 2016. PMID: 27412986 Free PMC article.
Culture of Drosophila expressing the steroid-dependent GeneSwitch transcriptional activator under the control of the ubiquitous alpha-tubulin promoter was found to produce extensive pupal lethality, as well as a range of dysmorphic adult phenotypes, in the presence …
Culture of Drosophila expressing the steroid-dependent GeneSwitch transcriptional activator under the control of the ubiquitou …
Myc suppresses male-male courtship in Drosophila.
Pan Y, Li W, Deng Z, Sun Y, Ma X, Liang R, Guo X, Sun Y, Li W, Jiao R, Xue L. Pan Y, et al. EMBO J. 2022 Apr 4;41(7):e109905. doi: 10.15252/embj.2021109905. Epub 2022 Feb 15. EMBO J. 2022. PMID: 35167135 Free PMC article.
Here, we report that the proto-oncogene Myc is required in dopaminergic neurons to inhibit Drosophila male-male courtship. Loss of Myc, either by mutation or neuro-specific knockdown, induced males' courtship propensity toward other males. ...Finally, drug-mediated Myc dep …
Here, we report that the proto-oncogene Myc is required in dopaminergic neurons to inhibit Drosophila male-male courtship. Loss of My …
Examination of Niddm20 candidate genes of OLETF rats in Drosophila melanogaster using inducible GeneSwitch GAL4 system.
Enli L, Moronuki Y, Yamada T, Kose H. Enli L, et al. J Genet. 2022;101:15. J Genet. 2022. PMID: 35129134 Free article.
While remarkable progress have been made in our understanding of the genetic components that lead to disease expression, the 'diabetes genes' identified to date are inadequate for assessing disease risk, which suggests that many other genes remain to be discovered. Here, we used …
While remarkable progress have been made in our understanding of the genetic components that lead to disease expression, the 'diabetes genes …
Spatial and temporal control of gene expression in Drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers.
Nicholson L, Singh GK, Osterwalder T, Roman GW, Davis RL, Keshishian H. Nicholson L, et al. Genetics. 2008 Jan;178(1):215-34. doi: 10.1534/genetics.107.081968. Genetics. 2008. PMID: 18202369 Free PMC article.
A promising approach for this is the GeneSwitch GAL4 system of Drosophila. With GeneSwitch GAL4 the expression of upstream activating sequence (UAS) effector lines is controlled by a chimeric GAL4 protein that becomes active in the presence of the steroid RU4 …
A promising approach for this is the GeneSwitch GAL4 system of Drosophila. With GeneSwitch GAL4 the expression of upstr …
Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection.
Hayman DJ, Morrin LM, Halder S, Phillips EJ, Simons MJP, Evans IR. Hayman DJ, et al. J Exp Biol. 2025 May 1;228(9):jeb249649. doi: 10.1242/jeb.249649. Epub 2025 May 6. J Exp Biol. 2025. PMID: 40116111 Free PMC article.
Macrophages are responsible for diverse and fundamental functions in vertebrates. Drosophila blood cells (haemocytes) are dominated by cells bearing a striking homology to vertebrate macrophages (plasmatocytes). ...No effect on lifespan was observed from driving ras and ba …
Macrophages are responsible for diverse and fundamental functions in vertebrates. Drosophila blood cells (haemocytes) are dominated b …
Insect nuclear receptors.
Fahrbach SE, Smagghe G, Velarde RA. Fahrbach SE, et al. Annu Rev Entomol. 2012;57:83-106. doi: 10.1146/annurev-ento-120710-100607. Epub 2011 Oct 10. Annu Rev Entomol. 2012. PMID: 22017307 Review.
The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present …
The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains …
Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster.
Scialo F, Sriram A, Stefanatos R, Sanz A. Scialo F, et al. PLoS One. 2016 Aug 29;11(8):e0161817. doi: 10.1371/journal.pone.0161817. eCollection 2016. PLoS One. 2016. PMID: 27570965 Free PMC article.
Drosophila melanogaster is a popular research model organism thanks to its' powerful genetic tools that allow spatial and temporal control of gene expression. The inducible GeneSwitch Gal4 system (GS) system is a modified version of the classic UAS/GAL4 system which …
Drosophila melanogaster is a popular research model organism thanks to its' powerful genetic tools that allow spatial and temporal co …
Antimicrobial peptides extend lifespan in Drosophila.
Loch G, Zinke I, Mori T, Carrera P, Schroer J, Takeyama H, Hoch M. Loch G, et al. PLoS One. 2017 May 17;12(5):e0176689. doi: 10.1371/journal.pone.0176689. eCollection 2017. PLoS One. 2017. PMID: 28520752 Free PMC article.
We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSwitch system to tightly regulate AMP expression. We found that activation of single AMPs, including Drosocin, resulted in a significant extension of Drosophila life …
We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSwitch system to tightly regulat …
Mifepristone Reduces Food Palatability and Affects Drosophila Feeding and Lifespan.
Yamada R, Deshpande SA, Keebaugh ES, Ehrlich MR, Soto Obando A, Ja WW. Yamada R, et al. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):173-180. doi: 10.1093/gerona/glw072. Epub 2016 Apr 19. J Gerontol A Biol Sci Med Sci. 2017. PMID: 27093874 Free PMC article.
The Drosophila GeneSwitch system facilitates the spatial and temporal control of gene expression through dietary supplementation of mifepristone (RU486). Because experimental and control groups differ only by treatment with RU486, confounding results from using flie …
The Drosophila GeneSwitch system facilitates the spatial and temporal control of gene expression through dietary supplementati …
52 results