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Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells.
Laleve A, Panozzo C, Kühl I, Bourand-Plantefol A, Ostojic J, Sissoko A, Tribouillard-Tanvier D, Cornu D, Burg A, Meunier B, Blondel M, Clain J, Bonnefoy N, Duval R, Dujardin G. Laleve A, et al. Among authors: ostojic j. Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118661. doi: 10.1016/j.bbamcr.2020.118661. Epub 2020 Jan 25. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 31987792 Free article.
Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants.
Panozzo C, Laleve A, Tribouillard-Tanvier D, Ostojić J, Sellem CH, Friocourt G, Bourand-Plantefol A, Burg A, Delahodde A, Blondel M, Dujardin G. Panozzo C, et al. Among authors: ostojic j. Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2297-2307. doi: 10.1016/j.bbamcr.2017.09.003. Epub 2017 Sep 6. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28888990 Free article.
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