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Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function.
van de Vosse E, Lichtenauer-Kaligis EG, van Dissel JT, Ottenhoff TH. van de Vosse E, et al. Immunogenetics. 2003 Mar;54(12):817-29. doi: 10.1007/s00251-002-0534-9. Epub 2003 Feb 21. Immunogenetics. 2003. PMID: 12671732 Review.
The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes.
Janssen R, van Wengen A, Hoeve MA, ten Dam M, van der Burg M, van Dongen J, van de Vosse E, van Tol M, Bredius R, Ottenhoff TH, Weemaes C, van Dissel JT, Lankester A. Janssen R, et al. J Exp Med. 2004 Sep 6;200(5):559-68. doi: 10.1084/jem.20040773. Epub 2004 Aug 30. J Exp Med. 2004. PMID: 15337789 Free PMC article.
Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.
Netea MG, Azam T, Lewis EC, Joosten LA, Wang M, Langenberg D, Meng X, Chan ED, Yoon DY, Ottenhoff T, Kim SH, Dinarello CA. Netea MG, et al. PLoS Med. 2006 Aug;3(8):e277. doi: 10.1371/journal.pmed.0030277. PLoS Med. 2006. PMID: 16903774 Free PMC article.
A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis.
Joosten SA, Fletcher HA, Ottenhoff TH. Joosten SA, et al. PLoS One. 2013 Sep 16;8(9):e73230. doi: 10.1371/journal.pone.0073230. eCollection 2013. PLoS One. 2013. PMID: 24066041 Free PMC article.
Control of human host immunity to mycobacteria.
Ottenhoff TH, Verreck FA, Hoeve MA, van de Vosse E. Ottenhoff TH, et al. Tuberculosis (Edinb). 2005 Jan-Mar;85(1-2):53-64. doi: 10.1016/j.tube.2004.09.011. Epub 2004 Dec 31. Tuberculosis (Edinb). 2005. PMID: 15687028 Review.
New pathways of protective and pathological host defense to mycobacteria.
Ottenhoff TH. Ottenhoff TH. Trends Microbiol. 2012 Sep;20(9):419-28. doi: 10.1016/j.tim.2012.06.002. Epub 2012 Jul 10. Trends Microbiol. 2012. PMID: 22784857 Review.
Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection.
Geluk A, van der Ploeg J, Teles RO, Franken KL, Prins C, Drijfhout JW, Sarno EN, Sampaio EP, Ottenhoff TH. Geluk A, et al. Clin Vaccine Immunol. 2008 Mar;15(3):522-33. doi: 10.1128/CVI.00432-07. Epub 2008 Jan 16. Clin Vaccine Immunol. 2008. PMID: 18199740 Free PMC article.
Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions.
Geluk A, van Meijgaarden KE, Wilson L, Bobosha K, van der Ploeg-van Schip JJ, van den Eeden SJ, Quinten E, Dijkman K, Franken KL, Haisma EM, Haks MC, van Hees CL, Ottenhoff TH. Geluk A, et al. J Clin Immunol. 2014 Feb;34(2):245-55. doi: 10.1007/s10875-013-9979-x. Epub 2013 Dec 27. J Clin Immunol. 2014. PMID: 24370984
Genetic deficiencies of innate immune signalling in human infectious disease.
van de Vosse E, van Dissel JT, Ottenhoff TH. van de Vosse E, et al. Lancet Infect Dis. 2009 Nov;9(11):688-98. doi: 10.1016/S1473-3099(09)70255-5. Lancet Infect Dis. 2009. PMID: 19850227 Review.
Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.
Savage ND, de Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH. Savage ND, et al. J Immunol. 2008 Aug 1;181(3):2220-6. doi: 10.4049/jimmunol.181.3.2220. J Immunol. 2008. PMID: 18641362
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