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Multiple Sclerosis Is Rare in Epstein-Barr Virus-Seronegative Children with Central Nervous System Inflammatory Demyelination.
Nourbakhsh B, Cordano C, Asteggiano C, Ruprecht K, Otto C, Rutatangwa A, Lui A, Hart J, Flanagan EP, James JA, Waubant E. Nourbakhsh B, et al. Ann Neurol. 2021 Jun;89(6):1234-1239. doi: 10.1002/ana.26062. Epub 2021 Mar 24. Ann Neurol. 2021. PMID: 33704815 Free PMC article.
Although Epstein-Barr virus (EBV) is hypothesized to be a prerequisite for multiple sclerosis (MS), up to 15% of children with a diagnosis of MS were reported to be EBV-seronegative. ...After critical review, MS remained a plausible diagnosis in only 4 of 14 …
Although Epstein-Barr virus (EBV) is hypothesized to be a prerequisite for multiple sclerosis (MS), up to 15% of children with a diag …
Intrathecal EBV antibodies are part of the polyspecific immune response in multiple sclerosis.
Otto C, Oltmann A, Stein A, Frenzel K, Schroeter J, Habbel P, Gärtner B, Hofmann J, Ruprecht K. Otto C, et al. Neurology. 2011 Apr 12;76(15):1316-21. doi: 10.1212/WNL.0b013e318215286d. Neurology. 2011. PMID: 21482946
To discriminate whether elevated EBV AIs indicate a virus-driven or a polyspecific intrathecal immune response, we determined the intrathecal fraction of anti-EBV antibodies. ...All 24 patients with CIS/MS with an elevated EBV AI had at least one further elev …
To discriminate whether elevated EBV AIs indicate a virus-driven or a polyspecific intrathecal immune response, we determined the int …
Epstein-Barr virus antibodies in serum and DNA load in saliva are not associated with radiological or clinical disease activity in patients with early multiple sclerosis.
Gieß RM, Pfuhl C, Behrens JR, Rasche L, Freitag E, Khalighy N, Otto C, Wuerfel J, Brandt AU, Hofmann J, Eberspächer B, Bellmann-Strobl J, Paul F, Ruprecht K. Gieß RM, et al. PLoS One. 2017 Apr 7;12(4):e0175279. doi: 10.1371/journal.pone.0175279. eCollection 2017. PLoS One. 2017. PMID: 28388676 Free PMC article.
Likewise, levels of EBV IgG antibodies in serum and DNA load in saliva were not associated with conversion to CDMS. CONCLUSIONS: While these findings confirm the association of EBV infection with early MS, neither EBNA-1 nor VCA IgG antibodies in serum nor EBV
Likewise, levels of EBV IgG antibodies in serum and DNA load in saliva were not associated with conversion to CDMS. CONCLUSIONS: Whil …
Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein-Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis.
Otto C, Hofmann J, Ruprecht K. Otto C, et al. Med Hypotheses. 2016 Jun;91:109-113. doi: 10.1016/j.mehy.2016.04.025. Epub 2016 Apr 16. Med Hypotheses. 2016. PMID: 27142157
Strong and consistent evidence suggests an association of MS and Epstein-Barr virus (EBV) infection and EBV seroprevalence in patients with MS is practically 100%. ...As typical for humoral immune responses against viruses, EBV specific IgG is produced only w …
Strong and consistent evidence suggests an association of MS and Epstein-Barr virus (EBV) infection and EBV seroprevalence in …
Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis.
Pfuhl C, Oechtering J, Rasche L, Gieß RM, Behrens JR, Wakonig K, Freitag E, Pache FC, Otto C, Hofmann J, Eberspächer B, Bellmann-Strobl J, Paul F, Ruprecht K. Pfuhl C, et al. J Neuroimmunol. 2015 Aug 15;285:156-60. doi: 10.1016/j.jneuroim.2015.06.012. Epub 2015 Jun 25. J Neuroimmunol. 2015. PMID: 26198934
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. ...These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthe …
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synth …
Are there Epstein-Barr virus seronegative patients with multiple sclerosis?
Deuschle K, Hofmann J, Otto C, Bellmann-Strobl J, Scherner O, Klumbies K, Schneider E, Broddack J, Paul F, Ruprecht K. Deuschle K, et al. Mult Scler. 2013 Aug;19(9):1242-3. doi: 10.1177/1352458512472751. Epub 2013 Jan 10. Mult Scler. 2013. PMID: 23307904 No abstract available.
Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder.
Otto C, Radbruch H, Wilken D, Lietzow T, Steinhagen K, Grage-Griebenow E, von Brünneck AC, Jarius S, Hofmann J, Pache F, Ruprecht K. Otto C, et al. J Neuroimmunol. 2022 Aug 15;369:577902. doi: 10.1016/j.jneuroim.2022.577902. Epub 2022 Jun 2. J Neuroimmunol. 2022. PMID: 35689981
Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is strongly associated with Epstein-Barr virus (EBV). We analysed intrathecal production of EBV viral capsid antigen (VCA) immunoglobulin (Ig)G and IgA and Epstein-Barr nuclear a …
Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is strongly associated with Epstein-Barr virus (E