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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. Mahul-Mellier AL, et al. Among authors: oueslati a. Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9. Hum Mol Genet. 2014. PMID: 24412932 Free PMC article.
Phosphorylation of synucleins by members of the Polo-like kinase family.
Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA. Mbefo MK, et al. Among authors: oueslati a. J Biol Chem. 2010 Jan 22;285(4):2807-22. doi: 10.1074/jbc.M109.081950. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889641 Free PMC article.
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Paleologou KE, et al. Among authors: oueslati a. J Neurosci. 2010 Mar 3;30(9):3184-98. doi: 10.1523/JNEUROSCI.5922-09.2010. J Neurosci. 2010. PMID: 20203178 Free PMC article.
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. Khalaf O, et al. Among authors: oueslati a. J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936070 Free PMC article.
116 results