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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1977 1
1978 2
1979 2
1980 3
1981 3
1982 4
1983 4
1984 11
1985 5
1986 6
1987 5
1988 6
1989 3
1991 3
1992 2
1993 3
1994 3
1995 7
1996 5
1997 5
1998 9
1999 9
2000 4
2001 2
2002 3
2003 2
2004 5
2005 4
2006 6
2007 1
2008 3
2009 3
2010 3
2011 1
2012 2
2013 3
2014 2
2015 1
2016 6
2017 2
2018 3
2019 6
2020 7
2021 3
2022 10
2023 4
2024 1

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183 results

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Page 1
Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations.
Bonkovsky HL, Ghabril M, Nicoletti P, Dellinger A, Fontana RJ, Barnhart H, Gu J, Daly AK, Aithal GP, Phillips EJ, Kleiner DE; US DILIN Investigators. Bonkovsky HL, et al. Liver Int. 2024 Mar 7. doi: 10.1111/liv.15892. Online ahead of print. Liver Int. 2024. PMID: 38451034
Diclofenac was the causative drug in 29, celecoxib in 7, ibuprofen in 5, etodolac and meloxicam each in 4. Except for meloxicam and oxaprozin (n = 2), the liver injury was hepatocellular with median R 15-25. ...
Diclofenac was the causative drug in 29, celecoxib in 7, ibuprofen in 5, etodolac and meloxicam each in 4. Except for meloxicam and oxapr …
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency.
Adouvi G, Nawa F, Ballarotto M, Rüger LA, Knümann L, Kasch T, Arifi S, Schubert-Zsilavecz M, Willems S, Marschner JA, Pabel J, Merk D. Adouvi G, et al. J Med Chem. 2023 Dec 28;66(24):16762-16771. doi: 10.1021/acs.jmedchem.3c01435. Epub 2023 Dec 8. J Med Chem. 2023. PMID: 38064686
To mimic and exploit this natural ligand motif, we probed its structural fusion with synthetic RXR modulator scaffolds, which had profound effects on agonist activity and remarkably boosted potency of an oxaprozin-derived RXR agonist chemotype. Bioisosteric replacement of …
To mimic and exploit this natural ligand motif, we probed its structural fusion with synthetic RXR modulator scaffolds, which had profound e …
Drug repositioning for idiopathic epilepsy using gene expression signature data.
Kumar P, Sheokand D, Grewal A, Saini V, Kumar A. Kumar P, et al. Bioinformation. 2022 Oct 31;18(10):845-852. doi: 10.6026/97320630018845. eCollection 2022. Bioinformation. 2022. PMID: 37654844 Free PMC article.
Twenty-one predicted drug compounds showed better binding affinity than respective standards against the selected epileptic receptors. Among these drug compounds, Ergocalciferol, Oxaprozin, Flunarizine, Triprolidine and Cyproheptadine have been previously reported for anti …
Twenty-one predicted drug compounds showed better binding affinity than respective standards against the selected epileptic receptors. Among …
Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide.
Itoh H, Yamashita N, Kamijo S, Masuda K, Kato H, Yamaori S. Itoh H, et al. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25. Chem Biol Interact. 2023. PMID: 37499995
Sulindac sulfide, ibuprofen, and flurbiprofen effectively decreased the luciferin-4A O-demethylase activity of HLMs and recombinant CYP4A11 (inhibition rates of 30-96% at an inhibitor concentration of 100 muM), while salicylic acid, aspirin, diclofenac, mefenamic acid, indomethac …
Sulindac sulfide, ibuprofen, and flurbiprofen effectively decreased the luciferin-4A O-demethylase activity of HLMs and recombinant CYP4A11 …
Carbon Dioxide Radical Anion by Photoinduced Equilibration between Formate Salts and [11C, 13C, 14C]CO2: Application to Carbon Isotope Radiolabeling.
Malandain A, Molins M, Hauwelle A, Talbot A, Loreau O, D'Anfray T, Goutal S, Tournier N, Taran F, Caillé F, Audisio D. Malandain A, et al. J Am Chem Soc. 2023 Aug 2;145(30):16760-16770. doi: 10.1021/jacs.3c04679. Epub 2023 Jul 24. J Am Chem Soc. 2023. PMID: 37486080
The relevance of the method in applied radiochemistry was showcased by the whole-body PET biodistribution profile of [(11)C]oxaprozin in mice....
The relevance of the method in applied radiochemistry was showcased by the whole-body PET biodistribution profile of [(11)C]oxaprozin …
Transition metal(II) complexes with the non-steroidal anti-inflammatory drug oxaprozin: Characterization and biological profile.
Lazou M, Hatzidimitriou AG, Papadopoulos AN, Psomas G. Lazou M, et al. J Inorg Biochem. 2023 Jun;243:112196. doi: 10.1016/j.jinorgbio.2023.112196. Epub 2023 Mar 17. J Inorg Biochem. 2023. PMID: 36966675
A series of copper(II), nickel(II) and cobalt(II) complexes with the non-steroidal anti-inflammatory drug oxaprozin (Hoxa) have been synthesized and characterized by diverse techniques. ...
A series of copper(II), nickel(II) and cobalt(II) complexes with the non-steroidal anti-inflammatory drug oxaprozin (Hoxa) have been …
Two Binding Sites of SARS-CoV-2 Macrodomain 3 Probed by Oxaprozin and Meclomen.
Li J, Zhong F, Li M, Liu Y, Wang L, Liu M, Li F, Zhang J, Wu J, Shi Y, Zhang Z, Tu X, Ruan K, Gao J. Li J, et al. J Med Chem. 2022 Nov 24;65(22):15227-15237. doi: 10.1021/acs.jmedchem.2c01168. Epub 2022 Nov 10. J Med Chem. 2022. PMID: 36356292
Meclomen binds to site I of SARS-CoV-2 Mac3 with binding pose determined by NMR CSP and transferred paramagnetic relaxation enhancement, while oxaprozin binds to site II as revealed by the crystal structure. Interestingly, oxaprozin and meclomen both perturb residue …
Meclomen binds to site I of SARS-CoV-2 Mac3 with binding pose determined by NMR CSP and transferred paramagnetic relaxation enhancement, whi …
Application of CO(2) Supercritical Fluid to Optimize the Solubility of Oxaprozin: Development of Novel Machine Learning Predictive Models.
Alshahrani SM, Saqr AA, Alfadhel MM, Alshetaili AS, Almutairy BK, Alsubaiyel AM, Almari AH, Alamoudi JA, Abourehab MAS. Alshahrani SM, et al. Molecules. 2022 Sep 6;27(18):5762. doi: 10.3390/molecules27185762. Molecules. 2022. PMID: 36144490 Free PMC article.
In this paper, an artificial intelligence (AI) method has been used as an efficient and versatile tool to predict and consequently optimize the solubility of oxaprozin in SCCO(2) systems. Three learning methods, including multi-layer perceptron (MLP), Kriging or Gaussian p …
In this paper, an artificial intelligence (AI) method has been used as an efficient and versatile tool to predict and consequently optimize …
Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists.
Helmstädter M, Schierle S, Isigkeit L, Proschak E, Marschner JA, Merk D. Helmstädter M, et al. Int J Mol Sci. 2022 Sep 3;23(17):10070. doi: 10.3390/ijms231710070. Int J Mol Sci. 2022. PMID: 36077469 Free PMC article.
The screening dataset may therefore valuably contribute to such tools. Oxaprozin (RXR), tianeptine (PPARdelta), mycophenolic acid (RAR), and bortezomib (RAR) exhibited selective agonism on one nuclear receptor and emerged as attractive leads for the selective optimization …
The screening dataset may therefore valuably contribute to such tools. Oxaprozin (RXR), tianeptine (PPARdelta), mycophenolic acid (RA …
Development a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning.
Abdelbasset WK, Elkholi SM, Ismail KA, Alshehri S, Alobaida A, Huwaimel B, Alatawi AD, Alsubaiyel AM, Venkatesan K, Abourehab MAS. Abdelbasset WK, et al. Sci Rep. 2022 Jul 30;12(1):13138. doi: 10.1038/s41598-022-17440-4. Sci Rep. 2022. PMID: 35908085 Free PMC article.
Over the last decades, the application of supercritical fluids (SCFs), mainly CO(2), has found great interest as a promising solution to dominate the limitations of traditional methods including high toxicity, difficulty of control, high expense and low stability. Oxaprozin …
Over the last decades, the application of supercritical fluids (SCFs), mainly CO(2), has found great interest as a promising solution to dom …
183 results