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Oxiconazole.
[No authors listed] [No authors listed] 2024 Nov 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2024 Nov 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000487 Free Books & Documents. Review.
Topical oxiconazole has not been studied during breastfeeding. Because less than 1% is absorbed after topical application, it is considered a low risk to the nursing infant.[1] Avoid application to the nipple area and ensure that the infant's skin does not come into direct …
Topical oxiconazole has not been studied during breastfeeding. Because less than 1% is absorbed after topical application, it is cons …
Oxiconazole Potentiates Gentamicin against Gentamicin-Resistant Staphylococcus aureus In Vitro and In Vivo.
Kaul G, Akhir A, Shukla M, Shafi H, Akunuri R, Pawar G, Ghouse M, Srinivas N, Chopra S. Kaul G, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0503122. doi: 10.1128/spectrum.05031-22. Epub 2023 Jul 10. Microbiol Spectr. 2023. PMID: 37428033 Free PMC article.
In this study, we have repurposed a topical antifungal agent, oxiconazole, in combination with gentamicin against skin infections caused by multidrug-resistant Staphylococcus aureus. Oxiconazole was identified as having antibacterial activity against S. aureus via w …
In this study, we have repurposed a topical antifungal agent, oxiconazole, in combination with gentamicin against skin infections cau …
Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent.
Jegasothy BV, Pakes GE. Jegasothy BV, et al. Clin Ther. 1991 Jan-Feb;13(1):126-41. Clin Ther. 1991. PMID: 2029718 Review.
Tolerability of oxiconazole and the other antifungal creams was similar; in irritation studies oxiconazole was better tolerated than econazole. Oxiconazole cream exerts no detectable systemic effect since only a negligible amount is absorbed from the skin. .. …
Tolerability of oxiconazole and the other antifungal creams was similar; in irritation studies oxiconazole was better tolerate …
Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest.
Shi J, Zhou L, Huang HS, Peng L, Xie N, Nice E, Fu L, Jiang C, Huang C. Shi J, et al. Int J Biol Sci. 2022 May 21;18(9):3747-3761. doi: 10.7150/ijbs.70679. eCollection 2022. Int J Biol Sci. 2022. PMID: 35813474 Free PMC article.
Colorectal cancer (CRC) is one of the most common malignancies worldwide, yet successful treatment still remains a challenge. In this study, we found that oxiconazole (OXI), a broad-spectrum antifungal agent, exhibits certain anti-tumor effect against CRC. ...
Colorectal cancer (CRC) is one of the most common malignancies worldwide, yet successful treatment still remains a challenge. In this study, …
Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1(-/-) mice.
Luo H, Cai Y, Shi H, Ma L, Zhang S, Yung KKL, Zhou P. Luo H, et al. Int Immunopharmacol. 2025 Jun 5;157:114742. doi: 10.1016/j.intimp.2025.114742. Epub 2025 May 3. Int Immunopharmacol. 2025. PMID: 40319749
In this study, we evaluated the regulation of FDA-approved azole antifungal drugs on the cGAS-STING pathway. Among these drugs, oxiconazole, miconazole, and itraconazole demonstrate significant inhibitory effects, with oxiconazole showing the strongest activity. ... …
In this study, we evaluated the regulation of FDA-approved azole antifungal drugs on the cGAS-STING pathway. Among these drugs, oxiconazo …
Oxiconazole nitrate solid lipid nanoparticles: formulation, in-vitro characterization and clinical assessment of an analogous loaded carbopol gel.
Mahmoud RA, Hussein AK, Nasef GA, Mansour HF. Mahmoud RA, et al. Drug Dev Ind Pharm. 2020 May;46(5):706-716. doi: 10.1080/03639045.2020.1752707. Epub 2020 Apr 15. Drug Dev Ind Pharm. 2020. PMID: 32266837 Clinical Trial.
The aim of the present work was to develop a promising drug delivery system of oxiconazole nitrate-loaded solid lipid nanoparticles (SLNs) topical gel to enhance the drug effectiveness for the treatment of Tinea infection. ...The results revealed that the prepared oxico …
The aim of the present work was to develop a promising drug delivery system of oxiconazole nitrate-loaded solid lipid nanoparticles ( …
Evaluation of a novel oxiconazole nitrate formulation: The thermosensitive gel.
Arslan A, Kose Ozkan C, Sig AK, Dogan E, Esim O, Cetinkaya S, Atalay F, Tas C, Savaser A, Ozkan Y. Arslan A, et al. Saudi Pharm J. 2018 Jul;26(5):665-672. doi: 10.1016/j.jsps.2018.02.025. Epub 2018 Feb 19. Saudi Pharm J. 2018. PMID: 29991910 Free PMC article.
Characterization parameters of the thermosensitive gel formulation containing oxiconazole nitrate and time-dependent activity against Candida species was observed to be the same as those of the solution containing only oxiconazole nitrate. MIC, MFC and time-dependen …
Characterization parameters of the thermosensitive gel formulation containing oxiconazole nitrate and time-dependent activity against …
Oxiconazole, a new imidazole derivative. Evaluation of antifungal activity in vitro and in vivo.
Polak A. Polak A. Arzneimittelforschung. 1982;32(1):17-24. Arzneimittelforschung. 1982. PMID: 7037014
Synthesis of DNA was inhibited by subinhibitory concentrations of oxiconazole in parallel to cell multiplication, whereas synthesis of RNA, protein and carbohydrate was decreased to a lesser extent. ...Based on our findings, a clinical evaluation of oxiconazole as a …
Synthesis of DNA was inhibited by subinhibitory concentrations of oxiconazole in parallel to cell multiplication, whereas synthesis o …
Further in vitro studies with oxiconazole nitrate.
Shadomy S, Wang H, Shadomy HJ. Shadomy S, et al. Diagn Microbiol Infect Dis. 1988 Apr;9(4):231-7. doi: 10.1016/0732-8893(88)90114-9. Diagn Microbiol Infect Dis. 1988. PMID: 3180708
Oxiconazole nitrate was compared in vitro with ketoconazole and econazole nitrate in tests with 96 dermatophytes, 18 isolates of Malassezia furfur, and seven isolates of Exophiala werneckii. ...Econazole was the more active compound in tests with Microsporum species (41 is …
Oxiconazole nitrate was compared in vitro with ketoconazole and econazole nitrate in tests with 96 dermatophytes, 18 isolates of Mala …
In vitro susceptibility studies with oxiconazole (Ro 13-8996).
Gebhart RJ, Espinel-Ingroff A, Shadomy S. Gebhart RJ, et al. Chemotherapy. 1984;30(4):244-7. doi: 10.1159/000238275. Chemotherapy. 1984. PMID: 6086246
Oxiconazole (Ro 13-8996) is a recently described imidazole derivative intended for topical use. 128 isolates of pathogenic fungi were tested in vitro against oxiconazole, miconazole, and ketoconazole using an agar dilution method. Results indicated that miconazole w …
Oxiconazole (Ro 13-8996) is a recently described imidazole derivative intended for topical use. 128 isolates of pathogenic fungi were …
124 results