Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M.
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Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16.
Immunity. 2012.
PMID: 22342844
Free PMC article.
NLRP3 secondary signal activators such as ATP induced mitochondrial dysfunction and apoptosis, resulting in release of oxidized mitochondrial DNA (mtDNA) into the cytosol, where it bound to and activated the NLRP3 …
NLRP3 secondary signal activators such as ATP induced mitochondrial dysfunction and apoptosis, resulting in rele …