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39 results

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. Shimada K, et al. Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16. Immunity. 2012. PMID: 22342844 Free PMC article.
NLRP3 secondary signal activators such as ATP induced mitochondrial dysfunction and apoptosis, resulting in release of oxidized mitochondrial DNA (mtDNA) into the cytosol, where it bound to and activated the NLRP3
NLRP3 secondary signal activators such as ATP induced mitochondrial dysfunction and apoptosis, resulting in rele
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis.
Zhang W, Li G, Luo R, Lei J, Song Y, Wang B, Ma L, Liao Z, Ke W, Liu H, Hua W, Zhao K, Feng X, Wu X, Zhang Y, Wang K, Yang C. Zhang W, et al. Exp Mol Med. 2022 Feb;54(2):129-142. doi: 10.1038/s12276-022-00729-9. Epub 2022 Feb 10. Exp Mol Med. 2022. PMID: 35145201 Free PMC article.
Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the degree of IVD degeneration. Oxidative stress induced cGAS-STING axis activation and NLRP3 inflammasome-mediated …
Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the …
Mitochondrial DNA in NLRP3 inflammasome activation.
Qiu Y, Huang Y, Chen M, Yang Y, Li X, Zhang W. Qiu Y, et al. Int Immunopharmacol. 2022 Jul;108:108719. doi: 10.1016/j.intimp.2022.108719. Epub 2022 Mar 26. Int Immunopharmacol. 2022. PMID: 35349960 Review.
Intracellular mtDNA is easily oxidized and transferred to the cytoplasm, and directly binds to NLRP3 to activate NLRP3 inflammasome, the extracellular mtDNA is involved in the priming and activation of NLRP3 inflammasome as …
Intracellular mtDNA is easily oxidized and transferred to the cytoplasm, and directly binds to NLRP3 to activate NLR
Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
Zhu JY, Chen M, Mu WJ, Luo HY, Guo L. Zhu JY, et al. Metabolism. 2022 Sep;134:155241. doi: 10.1016/j.metabol.2022.155241. Epub 2022 Jun 21. Metabolism. 2022. PMID: 35750235 Free article.
On the contrary, hepatic overexpression of Higd1a ameliorated fatty liver, liver injury and inflammation in synergy with exercise. Mechanistically, deficiency of Higd1a in hepatocytes promoted free fatty acids (FFAs)-induced apoptosis and oxidative stress, an …
On the contrary, hepatic overexpression of Higd1a ameliorated fatty liver, liver injury and inflammation in synergy with exercise. Me …
Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-kappaB-NLRP3 axis.
Lu P, Zheng H, Meng H, Liu C, Duan L, Zhang J, Zhang Z, Gao J, Zhang Y, Sun T. Lu P, et al. J Transl Med. 2023 Jun 15;21(1):389. doi: 10.1186/s12967-023-04266-5. J Transl Med. 2023. PMID: 37322517 Free PMC article.
As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be recognized by TLR9 and triggers the expression of NF-kappaB and NLRP3 inflammasomes, inducing pyroptosis and inflammatory response. ...RESULTS: We used human NP specimen …
As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be recognized by TLR9 and triggers the express …
Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes.
Ward GA, McGraw KL, Abbas-Aghababazadeh F, Meyer BS, McLemore AF, Vincelette ND, Lam NB, Aldrich AL, Al Ali NH, Padron E, Pinilla-Ibarz J, Masala E, Santini V, Kosmider O, Fontenay M, Fenaux P, Johnson J, Fridley BL, List AF. Ward GA, et al. Blood Adv. 2021 Apr 27;5(8):2216-2228. doi: 10.1182/bloodadvances.2020003475. Blood Adv. 2021. PMID: 33890980 Free PMC article.
Thus, tools that may add to current diagnostic practices could aid in disease discrimination. Constitutive innate immune activation is a pathogenetic driver of ineffective hematopoiesis in MDS through Nod-like receptor protein 3 (NLRP3)-inflammasome-induced p …
Thus, tools that may add to current diagnostic practices could aid in disease discrimination. Constitutive innate immune activation i …
RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.
Guan Z, Li H, Zhang C, Huang Z, Ye M, Zhang Y, Li S, Peng K. Guan Z, et al. PLoS Pathog. 2024 Aug 30;20(8):e1012387. doi: 10.1371/journal.ppat.1012387. eCollection 2024 Aug. PLoS Pathog. 2024. PMID: 39213434 Free PMC article.
It is found that the host transcription inhibition effect of NSs causes rapid down-regulation of myeloid cell leukemia-1(MCL-1), a pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) protein family. MCL-1 down-regulation led to BAK activation in the mitochondria, …
It is found that the host transcription inhibition effect of NSs causes rapid down-regulation of myeloid cell leukemia-1(MCL-1), a pro-survi …
DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma.
Bai Q, Liu R, Quan C, Han X, Wang D, Wang C, Wang Z, Li L, Li L, Piao H, Song Y, Yan G. Bai Q, et al. Front Immunol. 2024 Jan 11;14:1289774. doi: 10.3389/fimmu.2023.1289774. eCollection 2023. Front Immunol. 2024. PMID: 38274803 Free PMC article.
Moreover, rmDEK also increased DRP1 expression, PINK1-Parkin-mediated mitophagy, NLRP3 inflammasome activation, and apoptosis. These effects were partially reversed in DEK(-/-) mice. ...Additionally, ATAD3A was highly expressed in HDM-induced asthma mo …
Moreover, rmDEK also increased DRP1 expression, PINK1-Parkin-mediated mitophagy, NLRP3 inflammasome activation, and …
Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice.
Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE. Schuster S, et al. J Lipid Res. 2018 Sep;59(9):1597-1609. doi: 10.1194/jlr.M083741. Epub 2018 Jul 3. J Lipid Res. 2018. PMID: 30084831 Free PMC article.
The livers of OXLAM-fed mice showed lower triglyceride concentrations, but higher FA oxidation and lipid peroxidation in association with increased oxidative stress. OXLAM-induced mitochondrial dysfunction was associated with reduced Complex I protein and hep …
The livers of OXLAM-fed mice showed lower triglyceride concentrations, but higher FA oxidation and lipid peroxidation in association …
Tumor-targeting hydroxyapatite nanoparticles for remodeling tumor immune microenvironment (TIME) by activating mitoDNA-pyroptosis pathway in cancer.
Yang Y, Yang J, Zhu N, Qiu H, Feng W, Chen Y, Chen X, Chen Y, Zheng W, Liang M, Lin T, Yu J, Guo Z. Yang Y, et al. J Nanobiotechnology. 2023 Dec 7;21(1):470. doi: 10.1186/s12951-023-02231-4. J Nanobiotechnology. 2023. PMID: 38062467 Free PMC article.
CS and HAP synergetically augmented mitochondrial calcium overload, inciting the production of substantial amount of reactive oxygen species (ROS) and the subsequent liberation of oxidized mitochondrial DNA (OX-mitoDNA). This intricate activation
CS and HAP synergetically augmented mitochondrial calcium overload, inciting the production of substantial amount of reactive oxygen …
39 results