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Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc.
Alter-Koltunoff M, Goren S, Nousbeck J, Feng CG, Sher A, Ozato K, Azriel A, Levi BZ. Alter-Koltunoff M, et al. Among authors: ozato k. J Biol Chem. 2008 Feb 1;283(5):2724-33. doi: 10.1074/jbc.M707704200. Epub 2007 Nov 28. J Biol Chem. 2008. PMID: 18045875
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