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Phagocytosis of microbes: complexity in action.
Underhill DM, Ozinsky A. Underhill DM, et al. Annu Rev Immunol. 2002;20:825-52. doi: 10.1146/annurev.immunol.20.103001.114744. Epub 2001 Dec 7. Annu Rev Immunol. 2002. PMID: 11861619 Review.
Binding specificity of Toll-like receptor cytoplasmic domains.
Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S. Brown V, et al. Eur J Immunol. 2006 Mar;36(3):742-53. doi: 10.1002/eji.200535158. Eur J Immunol. 2006. PMID: 16482509 Free PMC article.
Using chimeric TIR domains, we define the critical region responsible for differential MyD88 binding, and use a computational analysis of the critical region to reveal the amino acids that differ between MyD88 binders and non-binders. Remarkably, a single missense m …
Using chimeric TIR domains, we define the critical region responsible for differential MyD88 binding, and use a computational analysi …
Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes.
Hawn TR, Ozinsky A, Williams LM, Rodrigues S, Clark A, Pham U, Hill HR, Ochs H, Aderem A, Liles WC. Hawn TR, et al. Hum Immunol. 2005 Jul;66(7):842-7. doi: 10.1016/j.humimm.2005.04.009. Hum Immunol. 2005. PMID: 16112032
We hypothesized that HIES is due to a defect in the Toll-like receptor signaling pathway. We used a whole blood cytokine assay to compare inflammatory responses to stimulation with specific Toll-like receptor (TLR) pathway agonists in four individuals with HIES and …
We hypothesized that HIES is due to a defect in the Toll-like receptor signaling pathway. We used a whole blood cytokine assay …
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A. Hawn TR, et al. J Exp Med. 2003 Nov 17;198(10):1563-72. doi: 10.1084/jem.20031220. J Exp Med. 2003. PMID: 14623910 Free PMC article.
We demonstrated recently that TLR5 recognizes flagellin, a potent inflammatory stimulus present in the flagellar structure of many bacteria. Here, we show that a common stop codon polymorphism in the ligand-binding domain of TLR5 (TLR5392STOP) is unable to mediate f …
We demonstrated recently that TLR5 recognizes flagellin, a potent inflammatory stimulus present in the flagellar structure of many ba …
Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.
Marr KA, Balajee SA, Hawn TR, Ozinsky A, Pham U, Akira S, Aderem A, Liles WC. Marr KA, et al. Infect Immun. 2003 Sep;71(9):5280-6. doi: 10.1128/iai.71.9.5280-5286.2003. Infect Immun. 2003. PMID: 12933875 Free PMC article.
In contrast, ingestion and killing of A. fumigatus conidia was MyD88 independent. Cytokine production by MyD88(-/-) macrophages in response to C. albicans yeasts and hyphae was substantially decreased, but responses to A. fumigatus hyphae were preserved. These resul …
In contrast, ingestion and killing of A. fumigatus conidia was MyD88 independent. Cytokine production by MyD88(-/-) macrophages in re …
Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.
Hawn TR, Ozinsky A, Underhill DM, Buckner FS, Akira S, Aderem A. Hawn TR, et al. Microbes Infect. 2002 Jul;4(8):763-71. doi: 10.1016/s1286-4579(02)01596-4. Microbes Infect. 2002. PMID: 12270723
Transfection of macrophages with a dominant-negative version of myeloid differentiation factor 88 (MyD88), an adaptor protein which interacts with TLRs, inhibited activation of the IL-1 alpha promoter. ...Examination of promoter activation is a powerful tool for und …
Transfection of macrophages with a dominant-negative version of myeloid differentiation factor 88 (MyD88), an adaptor protein which i …
Toll-like receptors: key mediators of microbe detection.
Underhill DM, Ozinsky A. Underhill DM, et al. Curr Opin Immunol. 2002 Feb;14(1):103-10. doi: 10.1016/s0952-7915(01)00304-1. Curr Opin Immunol. 2002. PMID: 11790539 Review.
Recently, a host of new microbial products that activate specific Toll-like receptors have been defined, and additional components that mediate intracellular signaling have been identified. ...
Recently, a host of new microbial products that activate specific Toll-like receptors have been defined, and additional components th …
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. Hayashi F, et al. Nature. 2001 Apr 26;410(6832):1099-103. doi: 10.1038/35074106. Nature. 2001. PMID: 11323673
Flagellin, a principal component of bacterial flagella, is a virulence factor that is recognized by the innate immune system in organisms as diverse as flies, plants and mammals. ...Our data suggest that TLR5, a member of the evolutionarily conserved Toll-lik …
Flagellin, a principal component of bacterial flagella, is a virulence factor that is recognized by the innate immune system i …
Toll-like receptor-5 and the innate immune response to bacterial flagellin.
Smith KD, Ozinsky A. Smith KD, et al. Curr Top Microbiol Immunol. 2002;270:93-108. doi: 10.1007/978-3-642-59430-4_6. Curr Top Microbiol Immunol. 2002. PMID: 12467246 Review.
The bacterial flagellum (Latin, a whip) confers motility, on a wide range of bacterial species. Vertebrates, plants, and invertebrates all have evolved flagellar recognition systems that are activated by flagellin, the major component of the bacterial flagellar fila …
The bacterial flagellum (Latin, a whip) confers motility, on a wide range of bacterial species. Vertebrates, plants, and inver …
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