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Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia.
Shah VB, Ozment-Skelton TR, Williams DL, Keshvara L. Shah VB, et al. Among authors: ozment skelton tr. Mol Immunol. 2009 May;46(8-9):1845-53. doi: 10.1016/j.molimm.2009.01.014. Epub 2009 Feb 20. Mol Immunol. 2009. PMID: 19232731
Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis.
Williams DL, Li C, Ha T, Ozment-Skelton T, Kalbfleisch JH, Preiszner J, Brooks L, Breuel K, Schweitzer JB. Williams DL, et al. J Immunol. 2004 Jan 1;172(1):449-56. doi: 10.4049/jimmunol.172.1.449. J Immunol. 2004. PMID: 14688354
Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner.
Shah VB, Huang Y, Keshwara R, Ozment-Skelton T, Williams DL, Keshvara L. Shah VB, et al. J Immunol. 2008 Mar 1;180(5):2777-85. doi: 10.4049/jimmunol.180.5.2777. J Immunol. 2008. PMID: 18292498
Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration.
Ozment-Skelton TR, Goldman MP, Gordon S, Brown GD, Williams DL. Ozment-Skelton TR, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):540-6. doi: 10.1124/jpet.106.102293. Epub 2006 Apr 21. J Pharmacol Exp Ther. 2006. PMID: 16632639
Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.
Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, Deponti WK, Kalbfleisch JH, Ensley HE, Brown GD, Gordon S, Williams DL. Rice PJ, et al. J Pharmacol Exp Ther. 2005 Sep;314(3):1079-86. doi: 10.1124/jpet.105.085415. Epub 2005 Jun 23. J Pharmacol Exp Ther. 2005. PMID: 15976018
Lipopolysaccharides directly decrease Ca2+ oscillations and the hyperpolarization-activated nonselective cation current If in immortalized HL-1 cardiomyocytes.
Wondergem R, Graves BM, Ozment-Skelton TR, Li C, Williams DL. Wondergem R, et al. Among authors: ozment skelton tr. Am J Physiol Cell Physiol. 2010 Sep;299(3):C665-71. doi: 10.1152/ajpcell.00129.2010. Epub 2010 Jun 23. Am J Physiol Cell Physiol. 2010. PMID: 20573997 Free PMC article.
Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury.
Williams DL, Ozment-Skelton T, Li C. Williams DL, et al. Shock. 2006 May;25(5):432-9. doi: 10.1097/01.shk.0000209542.76305.55. Shock. 2006. PMID: 16680006 Review.
Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis.
Ozment-Skelton TR, deFluiter EA, Ha T, Li C, Graves BM, Ferguson DA Jr, Schweitzer JB, Preizsner J, Brown GD, Gordon S, Kalbfleisch JH, Williams DL. Ozment-Skelton TR, et al. Crit Care Med. 2009 Mar;37(3):1038-45. doi: 10.1097/CCM.0b013e3181968fa0. Crit Care Med. 2009. PMID: 19237915 Free PMC article.
Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells.
Fan W, Ha T, Li Y, Ozment-Skelton T, Williams DL, Kelley J, Browder IW, Li C. Fan W, et al. Biochem Biophys Res Commun. 2005 Nov 25;337(3):840-8. doi: 10.1016/j.bbrc.2005.09.123. Epub 2005 Sep 29. Biochem Biophys Res Commun. 2005. PMID: 16213463