Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.
Gueugneau M, d'Hose D, Barbé C, de Barsy M, Lause P, Maiter D, Bindels LB, Delzenne NM, Schaeffer L, Gangloff YG, Chambon C, Coudy-Gandilhon C, Béchet D, Thissen JP.
Gueugneau M, et al. Among authors: lause p.
J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):929-946. doi: 10.1002/jcsm.12315. Epub 2018 Jul 10.
J Cachexia Sarcopenia Muscle. 2018.
PMID: 29989354
Free PMC article.
Our original in vitro results were confirmed in vivo by an increased expression of Serpina3n in skeletal muscle (3.9-fold; P < 0.01) and in the serum (two-fold; P < 0.01) of mice treated with GC. We also observed increased levels of the human orthologue Serpin
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Our original in vitro results were confirmed in vivo by an increased expression of Serpina3n in skeletal muscle (3.9-fold; P < 0.0
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