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Page 1
Administration of adiponectin receptor agonist AdipoRon relieves cancer cachexia by mitigating inflammation in tumour-bearing mice.
Massart IS, Kouakou AN, Pelet N, Lause P, Schakman O, Loumaye A, Abou-Samra M, Deldicque L, Bindels LB, Brichard SM, Thissen JP. Massart IS, et al. Among authors: lause p. J Cachexia Sarcopenia Muscle. 2024 Jun;15(3):919-933. doi: 10.1002/jcsm.13454. Epub 2024 Apr 4. J Cachexia Sarcopenia Muscle. 2024. PMID: 38572511 Free PMC article.

C26, P < 0.001 and -80% vs. Apc mice, P < 0.05), reduced muscular inflammation as indicated by lower levels of Socs3, phospho-STAT3 and Serpina3n, an acute phase reactant (P < 0.05 for all). In addition, AR blunted circulating levels of corticosteron

C26, P < 0.001 and -80% vs. Apc mice, P < 0.05), reduced muscular inflammation as indicated by lower levels of Socs3, ph

Circulating myostatin as a biomarker of muscle mass and strength in individuals with cancer or obesity.
Orioli L, Samaras S, Sawadogo K, de Barsy M, Lause P, Deswysen Y, Navez B, Thissen JP, Loumaye A. Orioli L, et al. Among authors: lause p. Clin Nutr. 2024 Jul;43(7):1800-1808. doi: 10.1016/j.clnu.2024.05.046. Epub 2024 May 31. Clin Nutr. 2024. PMID: 38861892 Free article.

MSTN was also lower in CC individuals than in NC individuals (1434 pg/mL vs 2149 pg/mL, p < 0.001). Muscle mass and strength were positively correlated with MSTN (SMMI: R = 0.500, p < 0.001; ASMMI: R = 0.479, p < 0.001; HGS: R = 0.495, p <

MSTN was also lower in CC individuals than in NC individuals (1434 pg/mL vs 2149 pg/mL, p < 0.001). Muscle mass and strength were

Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery.
Orioli L, Canouil M, Sawadogo K, Ning L, Deldicque L, Lause P, de Barsy M, Froguel P, Loumaye A, Deswysen Y, Navez B, Bonnefond A, Thissen JP. Orioli L, et al. Among authors: lause p. Eur J Endocrinol. 2023 Sep 1;189(3):409-421. doi: 10.1093/ejendo/lvad122. Eur J Endocrinol. 2023. PMID: 37638789

Decreased BDNF serum levels were associated with decreased HOMA of beta-cell function (HOMA-B) (adjusted estimate [95% CI] = 0.002 [0.00002-0.0031], P = .046). In the untargeted study, upregulated putative myokines included XYLT1 (+64%, P < .001), LGR5 (+57, P

Decreased BDNF serum levels were associated with decreased HOMA of beta-cell function (HOMA-B) (adjusted estimate [95% CI] = 0.002 [0.00002- …
Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.
Gueugneau M, d'Hose D, Barbé C, de Barsy M, Lause P, Maiter D, Bindels LB, Delzenne NM, Schaeffer L, Gangloff YG, Chambon C, Coudy-Gandilhon C, Béchet D, Thissen JP. Gueugneau M, et al. Among authors: lause p. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):929-946. doi: 10.1002/jcsm.12315. Epub 2018 Jul 10. J Cachexia Sarcopenia Muscle. 2018. PMID: 29989354 Free PMC article.

Our original in vitro results were confirmed in vivo by an increased expression of Serpina3n in skeletal muscle (3.9-fold; P < 0.01) and in the serum (two-fold; P < 0.01) of mice treated with GC. We also observed increased levels of the human orthologue Serpin

Our original in vitro results were confirmed in vivo by an increased expression of Serpina3n in skeletal muscle (3.9-fold; P < 0.0

Role of Activin A and myostatin in human cancer cachexia.
Loumaye A, de Barsy M, Nachit M, Lause P, Frateur L, van Maanen A, Trefois P, Gruson D, Thissen JP. Loumaye A, et al. Among authors: lause p. J Clin Endocrinol Metab. 2015 May;100(5):2030-8. doi: 10.1210/jc.2014-4318. Epub 2015 Mar 9. J Clin Endocrinol Metab. 2015. PMID: 25751105

RESULTS: Cachexia was associated with reduced lean and fat mass (p < .01 and p < .001), reduced physical function, lower quality of life, and increased symptoms (QLQC30; p < .001). Anorexia (SNAQ score < 14) was more common in cachectic patients (

RESULTS: Cachexia was associated with reduced lean and fat mass (p < .01 and p < .001), reduced physical function, lower

The Fate of Delayed Unions After Isolated Ankle Fusion.
Lause GE, Parker EB, Stupay KL, Chiodo CP, Bluman EM, Martin EA, Miller CP, Smith JT. Lause GE, et al. Foot Ankle Int. 2023 Sep;44(9):815-824. doi: 10.1177/10711007231178541. Epub 2023 Jun 13. Foot Ankle Int. 2023. PMID: 37312512
Patients with minimal or moderate fusion were more likely to succeed clinically than those with "absent" fusion (P = .040). Of those with absent fusion, 11 of 12 (92%) failed. In patients with minimal or moderate fusion, 9 of 16 (56%) failed. ...
Patients with minimal or moderate fusion were more likely to succeed clinically than those with "absent" fusion (P = .040). Of those …
Correlation of stress radiographs to injuries associated with lateral ankle instability.
Sy JW, Lopez AJ, Lausé GE, Deal JB, Lustik MB, Ryan PM. Sy JW, et al. Among authors: lause ge. World J Orthop. 2021 Sep 18;12(9):710-719. doi: 10.5312/wjo.v12.i9.710. eCollection 2021 Sep 18. World J Orthop. 2021. PMID: 34631454 Free PMC article.
RESULTS: A statistically significant association was determined for the mean and median stress radiographic values and the presence of peroneal pathology (P = 0.008 for tendonitis and P = 0.020 for peroneal tendon tears). A significant inverse relationship was found …
RESULTS: A statistically significant association was determined for the mean and median stress radiographic values and the presence of peron …
Circulating Activin A predicts survival in cancer patients.
Loumaye A, de Barsy M, Nachit M, Lause P, van Maanen A, Trefois P, Gruson D, Thissen JP. Loumaye A, et al. Among authors: lause p. J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):768-777. doi: 10.1002/jcsm.12209. Epub 2017 Jul 15. J Cachexia Sarcopenia Muscle. 2017. PMID: 28712119 Free PMC article.

Patients with high ActA (408 pg/mL) had lower OS than those with low levels, regardless the type of cancer (OS in colorectal cancer, 50% vs. 79%, P < 0.05; and in lung cancer, 27% vs. 67%, P = 0.001). The multivariable analysis confirmed the prognostic value of A

Patients with high ActA (408 pg/mL) had lower OS than those with low levels, regardless the type of cancer (OS in colorectal cancer, 50% vs. …
Decreased Craniocervical CSF Flow in Patients with Normal Pressure Hydrocephalus: A Pilot Study.
Stöcklein SM, Brandlhuber M, Lause SS, Pomschar A, Jahn K, Schniepp R, Alperin N, Ertl-Wagner B. Stöcklein SM, et al. Among authors: lause ss. AJNR Am J Neuroradiol. 2022 Feb;43(2):230-237. doi: 10.3174/ajnr.A7385. Epub 2022 Jan 6. AJNR Am J Neuroradiol. 2022. PMID: 34992125 Free PMC article.

RESULTS: The maximal systolic CSF flow rate was significantly decreased in patients with normal pressure hydrocephalus compared with age-matched and young healthy controls (53 [SD, 40] mL/m; 329 [SD, 175] mL/m; 472 [SD, 194] mL/m; each P < .01), whereas there were no si

RESULTS: The maximal systolic CSF flow rate was significantly decreased in patients with normal pressure hydrocephalus compared with age-mat …
Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy.
Gilson H, Schakman O, Combaret L, Lause P, Grobet L, Attaix D, Ketelslegers JM, Thissen JP. Gilson H, et al. Among authors: lause p. Endocrinology. 2007 Jan;148(1):452-60. doi: 10.1210/en.2006-0539. Epub 2006 Oct 12. Endocrinology. 2007. PMID: 17038559

In wild-type mice, daily administration of low-dose dexamethasone for 10 d resulted in muscle atrophy (tibialis anterior: -15%; gastrocnemius: -13%; P < 0.01) due to 15% decrease in the muscle fiber cross-sectional area (1621 +/- 31 vs. 1918 +/- 64 microm(2), P &

In wild-type mice, daily administration of low-dose dexamethasone for 10 d resulted in muscle atrophy (tibialis anterior: -15%; gastrocnemiu …
38 results