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In vitro and in vivo effects of P-MAPA immunomodulator on schistosomiasis.
Silva JCS, Lins CRB, Lacerda SS, Ramos REM, Araújo HDA, Melo-Junior MR, Alves LC, Brayner FA, Nunes IS, Melo FL, Carvalho BM. Silva JCS, et al. Acta Trop. 2021 Jun;218:105909. doi: 10.1016/j.actatropica.2021.105909. Epub 2021 Mar 28. Acta Trop. 2021. PMID: 33789153
In vitro, P-MAPA (5, 50, and 100 g/mL) damaged the Schistosoma mansoni tegument, causing thorn losses and tuber destruction in male worms and peeling and erosion in females after 24-h incubation. In vivo, P-MAPA (5 and 100 mg/kg, alone and combined wi …
In vitro, P-MAPA (5, 50, and 100 g/mL) damaged the Schistosoma mansoni tegument, causing thorn losses and tuber destruction i …
Improvement in clinical signs and cellular immunity of dogs with visceral leishmaniasis using the immunomodulator P-MAPA.
Santiago ME, Neto LS, Alexandre EC, Munari DP, Andrade MM, Somenzari MA, Ciarlini PC, de Lima VM. Santiago ME, et al. Acta Trop. 2013 Sep;127(3):174-80. doi: 10.1016/j.actatropica.2013.04.005. Epub 2013 Apr 29. Acta Trop. 2013. PMID: 23639468 Free article. Clinical Trial.
In addition, the in vitro leishmanicidal action of P-MAPA was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and no leishmanicidal activity was detected. These findings suggest that P-MAPA has potential as an immu …
In addition, the in vitro leishmanicidal action of P-MAPA was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetr …