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2009 270
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8,655 results

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Page 1
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons.
Hubstenberger A, Courel M, Bénard M, Souquere S, Ernoult-Lange M, Chouaib R, Yi Z, Morlot JB, Munier A, Fradet M, Daunesse M, Bertrand E, Pierron G, Mozziconacci J, Kress M, Weil D. Hubstenberger A, et al. Mol Cell. 2017 Oct 5;68(1):144-157.e5. doi: 10.1016/j.molcel.2017.09.003. Epub 2017 Sep 28. Mol Cell. 2017. PMID: 28965817 Free article.
Here, by developing a fluorescence-activated particle sorting (FAPS) method to purify cytosolic processing bodies (P-bodies) from human epithelial cells, we identified hundreds of proteins and thousands of mRNAs that structure a dense network of interactions, …
Here, by developing a fluorescence-activated particle sorting (FAPS) method to purify cytosolic processing bodies (P-bodies …
P-body-like condensates in the germline.
Cassani M, Seydoux G. Cassani M, et al. Semin Cell Dev Biol. 2024 Apr;157:24-32. doi: 10.1016/j.semcdb.2023.06.010. Epub 2023 Jul 3. Semin Cell Dev Biol. 2024. PMID: 37407370 Free PMC article. Review.
The activity of the universal germ cell fate regulator, Nanos, is linked to the mRNA decay function of P-bodies, and spatially-regulated condensation of P-body like condensates in embryos is required to localize mRNA regulators to primordial germ cells. ...We …
The activity of the universal germ cell fate regulator, Nanos, is linked to the mRNA decay function of P-bodies, and spatially-regula …
Properties of Stress Granule and P-Body Proteomes.
Youn JY, Dyakov BJA, Zhang J, Knight JDR, Vernon RM, Forman-Kay JD, Gingras AC. Youn JY, et al. Mol Cell. 2019 Oct 17;76(2):286-294. doi: 10.1016/j.molcel.2019.09.014. Mol Cell. 2019. PMID: 31626750 Free article. Review.
Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form by the phase separation of RNAs and proteins. ...Similarly, translationally stalled mRNAs devoid of translation initiation factors shuttle to P-bodies (PBs). Here, we review th …
Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form by the phase separation of RNAs and protein …
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Ripin N, Macedo de Vasconcelos L, Ugay DA, Parker R. Ripin N, et al. J Cell Biol. 2024 Jun 3;223(6):e202306022. doi: 10.1083/jcb.202306022. Epub 2024 Mar 27. J Cell Biol. 2024. PMID: 38536035 Free PMC article.
Herein, we demonstrate that the DEAD-box helicase DDX6, a P-body component, can also limit the formation of stress granules, independent of the formation of P-bodies. ...Moreover, we show that loss of DDX6, 4E-T, and DCP1A increases P-body docki …
Herein, we demonstrate that the DEAD-box helicase DDX6, a P-body component, can also limit the formation of stress granules, i …
Processing body (P-body) and its mediators in cancer.
Nsengimana B, Khan FA, Ngowi EE, Zhou X, Jin Y, Jia Y, Wei W, Ji S. Nsengimana B, et al. Mol Cell Biochem. 2022 Apr;477(4):1217-1238. doi: 10.1007/s11010-022-04359-7. Epub 2022 Jan 28. Mol Cell Biochem. 2022. PMID: 35089528 Review.
In recent years, processing bodies (P-bodies) formed by liquid-liquid phase separation, have attracted growing scientific attention due to their involvement in numerous cellular activities, including the regulation of mRNAs decay or storage. ...The mRNA metab …
In recent years, processing bodies (P-bodies) formed by liquid-liquid phase separation, have attracted growing scientif …
P-Bodies: Composition, Properties, and Functions.
Luo Y, Na Z, Slavoff SA. Luo Y, et al. Biochemistry. 2018 May 1;57(17):2424-2431. doi: 10.1021/acs.biochem.7b01162. Epub 2018 Jan 30. Biochemistry. 2018. PMID: 29381060 Free PMC article. Review.
Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. ...Here we review recent advances in o …
Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally rep …
m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.
Shan T, Liu F, Wen M, Chen Z, Li S, Wang Y, Cheng H, Zhou Y. Shan T, et al. Mol Cell. 2023 Dec 21;83(24):4494-4508.e6. doi: 10.1016/j.molcel.2023.10.040. Epub 2023 Nov 27. Mol Cell. 2023. PMID: 38016476 Free article.
Here, we report that m(6)A regulates mRNA partitioning between polysome and P-body where a pool of non-translating mRNAs resides. By quantifying the m(6)A level of polysomal and cytoplasmic mRNAs with m(6)A-LAIC-seq and m(6)A-LC-MS/MS in HeLa cells, we observed that …
Here, we report that m(6)A regulates mRNA partitioning between polysome and P-body where a pool of non-translating mRNAs resid …
YAP/TAZ enhances P-body formation to promote tumorigenesis.
Shen X, Peng X, Guo Y, Dai Z, Cui L, Yu W, Liu Y, Liu CY. Shen X, et al. Elife. 2024 Jul 24;12:RP88573. doi: 10.7554/eLife.88573. Elife. 2024. PMID: 39046443 Free PMC article.
The role of processing bodies (P-bodies) in tumorigenesis and tumor progression is not well understood. ...Our study suggests that the P-body is a new downstream effector of YAP/TAZ, which implies that reexpression of PNRC1 or disruption of P- …
The role of processing bodies (P-bodies) in tumorigenesis and tumor progression is not well understood. ...Our study su …
UPF1 P-body localization.
Brogna S, Ramanathan P, Wen J. Brogna S, et al. Biochem Soc Trans. 2008 Aug;36(Pt 4):698-700. doi: 10.1042/BST0360698. Biochem Soc Trans. 2008. PMID: 18631143 Review.
However, recent studies have indicated that the core NMD factors UPF1 (up-frameshift-1), UPF2 and UPF3 can associate with P-bodies (processing bodies), which are large cytoplasmic granules replete with proteins involved in general mRNA decay and related proce …
However, recent studies have indicated that the core NMD factors UPF1 (up-frameshift-1), UPF2 and UPF3 can associate with P-bodies ( …
Stress granule and P-body clearance: Seeking coherence in acts of disappearance.
Buchan JR. Buchan JR. Semin Cell Dev Biol. 2024 Jun-Jul;159-160:10-26. doi: 10.1016/j.semcdb.2024.01.002. Epub 2024 Jan 25. Semin Cell Dev Biol. 2024. PMID: 38278052 Free PMC article. Review.
Stress granules and P-bodies are conserved cytoplasmic biomolecular condensates whose assembly and composition are well documented, but whose clearance mechanisms remain controversial or poorly described. ...Here, I review and compare the contributions of chaperones, the c …
Stress granules and P-bodies are conserved cytoplasmic biomolecular condensates whose assembly and composition are well documented, b …
8,655 results