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Aging, cellular senescence, and cancer.
Campisi J. Campisi J. Annu Rev Physiol. 2013;75:685-705. doi: 10.1146/annurev-physiol-030212-183653. Epub 2012 Nov 8. Annu Rev Physiol. 2013. PMID: 23140366 Free PMC article. Review.
The role of senescent cells in ageing.
van Deursen JM. van Deursen JM. Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193. Nature. 2014. PMID: 24848057 Free PMC article. Review.
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. Zhu Y, et al. Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25754370 Free PMC article.
Senescence and apoptosis: dueling or complementary cell fates?
Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Childs BG, et al. EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. EMBO Rep. 2014. PMID: 25312810 Free PMC article. Review.
51 results