P01-GM32165/GM/NIGMS NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
1993	2
1994	1
1996	1
1997	1
1999	4
2000	2
2004	3
2005	1
2006	1
2007	3
2008	2
2009	3
2010	7
2011	4
2012	7
2013	4
2014	3
2015	2
2024	0

1

In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors.

Lutz JD, Isoherranen N. Lutz JD, et al. Expert Opin Drug Metab Toxicol. 2012 Apr;8(4):449-66. doi: 10.1517/17425255.2012.667801. Epub 2012 Mar 3. Expert Opin Drug Metab Toxicol. 2012. PMID: 22384784 Review.

2

The role of metabolites in predicting drug-drug interactions: focus on irreversible cytochrome P450 inhibition.

VandenBrink BM, Isoherranen N. VandenBrink BM, et al. Curr Opin Drug Discov Devel. 2010 Jan;13(1):66-77. Curr Opin Drug Discov Devel. 2010. PMID: 20047147 Free PMC article. Review.

3

Rationalization and prediction of in vivo metabolite exposures: the role of metabolite kinetics, clearance predictions and in vitro parameters.

Lutz JD, Fujioka Y, Isoherranen N. Lutz JD, et al. Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1095-109. doi: 10.1517/17425255.2010.497487. Expert Opin Drug Metab Toxicol. 2010. PMID: 20557268 Free PMC article. Review.

4

Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data.

Isoherranen N, Lutz JD, Chung SP, Hachad H, Levy RH, Ragueneau-Majlessi I. Isoherranen N, et al. Chem Res Toxicol. 2012 Nov 19;25(11):2285-300. doi: 10.1021/tx300192g. Epub 2012 Sep 27. Chem Res Toxicol. 2012. PMID: 22823924 Free PMC article. Review.

5

Qualitative analysis of the role of metabolites in inhibitory drug-drug interactions: literature evaluation based on the metabolism and transport drug interaction database.

Isoherranen N, Hachad H, Yeung CK, Levy RH. Isoherranen N, et al. Chem Res Toxicol. 2009 Feb;22(2):294-8. doi: 10.1021/tx800491e. Chem Res Toxicol. 2009. PMID: 19216580 Free PMC article. Review.

6

Risk assessment of mechanism-based inactivation in drug-drug interactions.

Fujioka Y, Kunze KL, Isoherranen N. Fujioka Y, et al. Drug Metab Dispos. 2012 Sep;40(9):1653-7. doi: 10.1124/dmd.112.046649. Epub 2012 Jun 8. Drug Metab Dispos. 2012. PMID: 22685217 Free PMC article.

7

Role of itraconazole metabolites in CYP3A4 inhibition.

Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Isoherranen N, et al. Drug Metab Dispos. 2004 Oct;32(10):1121-31. doi: 10.1124/dmd.104.000315. Epub 2004 Jul 8. Drug Metab Dispos. 2004. PMID: 15242978

8

P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms.

McDonald MG, Au NT, Rettie AE. McDonald MG, et al. Drug Metab Dispos. 2015 Nov;43(11):1661-9. doi: 10.1124/dmd.115.065623. Epub 2015 Aug 21. Drug Metab Dispos. 2015. PMID: 26296708 Free PMC article.

9

Characterization of inhibition kinetics of (S)-warfarin hydroxylation by noscapine: implications in warfarin therapy.

Zhang N, Seguin RP, Kunze KL, Zhang YY, Jeong H. Zhang N, et al. Drug Metab Dispos. 2013 Dec;41(12):2114-23. doi: 10.1124/dmd.113.053330. Epub 2013 Sep 17. Drug Metab Dispos. 2013. PMID: 24046330 Free PMC article.

10

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.

Peng CC, Shi W, Lutz JD, Kunze KL, Liu JO, Nelson WL, Isoherranen N. Peng CC, et al. Drug Metab Dispos. 2012 Mar;40(3):426-35. doi: 10.1124/dmd.111.042739. Epub 2011 Nov 21. Drug Metab Dispos. 2012. PMID: 22106171 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Results by year

Text availability

Article attribute

Article type

Publication date

44 results

Results by year

Search Page

Filters

My NCBI Filters

Results by year

Text availability

Article attribute

Article type

Publication date

Search Results

44 results

Results by year