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2014 1
2015 3
2016 3
2021 0
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Page 1
The role of autophagy in neurodegenerative disease.
Nixon RA. Nixon RA. Nat Med. 2013 Aug;19(8):983-97. doi: 10.1038/nm.3232. Epub 2013 Aug 6. Nat Med. 2013. PMID: 23921753 Review.
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification.
Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Wolfe DM, et al. Eur J Neurosci. 2013 Jun;37(12):1949-61. doi: 10.1111/ejn.12169. Eur J Neurosci. 2013. PMID: 23773064 Free PMC article.
Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.
Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PP, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA. Lee JH, et al. Cell Rep. 2015 Sep 1;12(9):1430-44. doi: 10.1016/j.celrep.2015.07.050. Epub 2015 Aug 20. Cell Rep. 2015. PMID: 26299959 Free PMC article.
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lee JH, et al. Cell. 2010 Jun 25;141(7):1146-58. doi: 10.1016/j.cell.2010.05.008. Epub 2010 Jun 10. Cell. 2010. PMID: 20541250 Free PMC article.
Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.
Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA. Rao MV, et al. J Neurochem. 2016 Apr;137(2):253-65. doi: 10.1111/jnc.13536. Epub 2016 Mar 23. J Neurochem. 2016. PMID: 26756888 Free PMC article.
Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease.
Xue X, Wang LR, Sato Y, Jiang Y, Berg M, Yang DS, Nixon RA, Liang XJ. Xue X, et al. Nano Lett. 2014 Sep 10;14(9):5110-7. doi: 10.1021/nl501839q. Epub 2014 Aug 21. Nano Lett. 2014. PMID: 25115676 Free PMC article.
Evidence that the rab5 effector APPL1 mediates APP-╬▓CTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.
Kim S, Sato Y, Mohan PS, Peterhoff C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA. Kim S, et al. Mol Psychiatry. 2016 May;21(5):707-16. doi: 10.1038/mp.2015.97. Epub 2015 Jul 21. Mol Psychiatry. 2016. PMID: 26194181 Free PMC article.
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.
Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Jiang Y, et al. Neurobiol Aging. 2016 Mar;39:90-8. doi: 10.1016/j.neurobiolaging.2015.11.013. Epub 2015 Dec 2. Neurobiol Aging. 2016. PMID: 26923405 Free PMC article.
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.
Lee S, Sato Y, Nixon RA. Lee S, et al. J Neurosci. 2011 May 25;31(21):7817-30. doi: 10.1523/JNEUROSCI.6412-10.2011. J Neurosci. 2011. PMID: 21613495 Free PMC article.
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