Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1969 2
1970 1
1973 1
1974 1
1975 13
1976 10
1977 13
1978 11
1979 13
1980 24
1981 23
1982 32
1983 46
1984 78
1985 103
1986 155
1987 194
1988 293
1989 343
1990 413
1991 402
1992 461
1993 461
1994 578
1995 681
1996 833
1997 1002
1998 1129
1999 1287
2000 1339
2001 1436
2002 1452
2003 1444
2004 1528
2005 1605
2006 1638
2007 1722
2008 1836
2009 1980
2010 2187
2011 2316
2012 2644
2013 2800
2014 2886
2015 2839
2016 2759
2017 2665
2018 2546
2019 2676
2020 2618
2021 2564
2022 2464
2023 2338
2024 2442
2025 2675
2026 1294

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

60,850 results

Results by year

Filters applied: . Clear all
Page 1
p21 in Cancer Research.
Shamloo B, Usluer S. Shamloo B, et al. Cancers (Basel). 2019 Aug 14;11(8):1178. doi: 10.3390/cancers11081178. Cancers (Basel). 2019. PMID: 31416295 Free PMC article. Review.
p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. ...Although tumor-suppressor function of p21 is the most studied aspect of this protein in cancer, the role of p21 in phenotypic plas …
p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. ...Alth …
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage.
Karimian A, Ahmadi Y, Yousefi B. Karimian A, et al. DNA Repair (Amst). 2016 Jun;42:63-71. doi: 10.1016/j.dnarep.2016.04.008. Epub 2016 Apr 22. DNA Repair (Amst). 2016. PMID: 27156098 Review.
The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modu …
The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p5 …
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo.
Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M. Wang B, et al. Nat Aging. 2021 Oct;1(10):962-973. doi: 10.1038/s43587-021-00107-6. Epub 2021 Oct 7. Nat Aging. 2021. PMID: 35024619 Free PMC article.
Currently, most transgenic mouse models only target p16 (Ink4a)-highly-expressing (p16 (high)) cells. Here, we generated a p21-Cre mouse model, containing a p21 promoter driving inducible Cre, enabling us to examine p21 (Cip1)-highly-expressing (p21 (h …
Currently, most transgenic mouse models only target p16 (Ink4a)-highly-expressing (p16 (high)) cells. Here, we generated a p21-Cre mo …
Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy.
Xiao BD, Zhao YJ, Jia XY, Wu J, Wang YG, Huang F. Xiao BD, et al. World J Stem Cells. 2020 Jun 26;12(6):481-487. doi: 10.4252/wjsc.v12.i6.481. World J Stem Cells. 2020. PMID: 32742565 Free PMC article. Review.
In addition, expression of p21 is closely related to the resting state or terminal differentiation of cells. p21 is also associated with cancer stem cells and acts as a biomarker for such cells. In cancer therapy, given the importance of p21 in regulating the …
In addition, expression of p21 is closely related to the resting state or terminal differentiation of cells. p21 is also assoc …
Peptides That Block RAS-p21 Protein-Induced Cell Transformation.
Pincus MR, Lin B, Patel P, Gabutan E, Zohar N, Bowne WB. Pincus MR, et al. Biomedicines. 2023 Feb 6;11(2):471. doi: 10.3390/biomedicines11020471. Biomedicines. 2023. PMID: 36831007 Free PMC article. Review.
These approaches comprise: molecular simulations of mutant and wild-type proteins to identify effector domains, for which peptides can be made that selectively inhibit the oncogenic protein that include PNC-1 (ras residues 115-126), PNC-2 (ras residues 96-110) and PNC7 (ras resid …
These approaches comprise: molecular simulations of mutant and wild-type proteins to identify effector domains, for which peptides can be ma …
p21(Waf1/Cip1): its paradoxical effect in the regulation of breast cancer.
Zohny SF, Al-Malki AL, Zamzami MA, Choudhry H. Zohny SF, et al. Breast Cancer. 2019 Mar;26(2):131-137. doi: 10.1007/s12282-018-0913-1. Epub 2018 Sep 25. Breast Cancer. 2019. PMID: 30255294 Review.
Conversely, it has been proposed that p21(Waf1/Cip1) may also function as an oncogene because it can inhibit apoptosis. Thus, p21(Waf1/Cip1) is regarded as a protein with a dual behavior, as its expression might cause potential benefits or dangerous effects in breas …
Conversely, it has been proposed that p21(Waf1/Cip1) may also function as an oncogene because it can inhibit apoptosis. Thus, p21 …
Multiple functions of p21 in cancer radiotherapy.
Kuang Y, Kang J, Li H, Liu B, Zhao X, Li L, Jin X, Li Q. Kuang Y, et al. J Cancer Res Clin Oncol. 2021 Apr;147(4):987-1006. doi: 10.1007/s00432-021-03529-2. Epub 2021 Feb 5. J Cancer Res Clin Oncol. 2021. PMID: 33547489 Free PMC article. Review.
With the deepening researches on p21, p21 has been found to regulate radiation responses via participating in multiple cellular processes, including cell cycle arrest, apoptosis, DNA repair, senescence and autophagy. ...Besides, more thorough insights of p21 …
With the deepening researches on p21, p21 has been found to regulate radiation responses via participating in multiple cellula …
The Emerging Role of p21 in Diabetes and Related Metabolic Disorders.
Elmitwalli O, Darwish R, Al-Jabery L, Algahiny A, Roy S, Butler AE, Hasan AS. Elmitwalli O, et al. Int J Mol Sci. 2024 Dec 9;25(23):13209. doi: 10.3390/ijms252313209. Int J Mol Sci. 2024. PMID: 39684919 Free PMC article. Review.
In the context of cell cycle inhibition, anti-proliferation, and the dysregulation observed in certain cancer pathologies, the protein p21 assumes a pivotal role. p21 links DNA damage responses to cellular processes such as apoptosis, senescence, and cell cycle arre …
In the context of cell cycle inhibition, anti-proliferation, and the dysregulation observed in certain cancer pathologies, the protein p2 …
CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication.
Mansilla SF, de la Vega MB, Calzetta NL, Siri SO, Gottifredi V. Mansilla SF, et al. Genes (Basel). 2020 May 28;11(6):593. doi: 10.3390/genes11060593. Genes (Basel). 2020. PMID: 32481484 Free PMC article. Review.
Vice versa, PCNA also regulates p21 by preventing its upregulation in the S phase, even in the context of robust p21 induction by irradiation. Such a tight regulation of p21 in the S phase unveils the potential that CDK-independent functions of p21 may …
Vice versa, PCNA also regulates p21 by preventing its upregulation in the S phase, even in the context of robust p21 induction …
p21 facilitates chronic lung inflammation via epithelial and endothelial cells.
Levi N, Papismadov N, Majewska J, Roitman L, Wigoda N, Eilam R, Tsoory M, Rotkopf R, Ovadya Y, Akiva H, Regev O, Krizhanovsky V. Levi N, et al. Aging (Albany NY). 2023 Mar 30;15(7):2395-2417. doi: 10.18632/aging.204622. Epub 2023 Mar 30. Aging (Albany NY). 2023. PMID: 36996500 Free PMC article.
One such pathology is chronic lung inflammation. p21 (CDKN1A) regulates cellular senescence via inhibition of cyclin-dependent kinases (CDKs). However, its role in chronic lung inflammation and functional impact on chronic lung disease, where senescent cells accumulate, is …
One such pathology is chronic lung inflammation. p21 (CDKN1A) regulates cellular senescence via inhibition of cyclin-dependent kinase …
60,850 results
You have reached the last available page of results. Please see the User Guide for more information.