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Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors.

Chang KO, Kim Y, Lovell S, Rathnayake AD, Groutas WC. Chang KO, et al. Viruses. 2019 Feb 25;11(2):197. doi: 10.3390/v11020197. Viruses. 2019. PMID: 30823509 Free PMC article. Review.

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3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.

Rathnayake AD, Zheng J, Kim Y, Perera KD, Mackin S, Meyerholz DK, Kashipathy MM, Battaile KP, Lovell S, Perlman S, Groutas WC, Chang KO. Rathnayake AD, et al. Sci Transl Med. 2020 Aug 19;12(557):eabc5332. doi: 10.1126/scitranslmed.abc5332. Epub 2020 Aug 3. Sci Transl Med. 2020. PMID: 32747425 Free PMC article.

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Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention.

Wu L, Zhang X, Zhao L. Wu L, et al. J Neurosci. 2018 Jul 25;38(30):6665-6681. doi: 10.1523/JNEUROSCI.2262-17.2018. Epub 2018 Jul 2. J Neurosci. 2018. PMID: 29967007 Free PMC article.

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Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC. Galasiti Kankanamalage AC, et al. Eur J Med Chem. 2018 Apr 25;150:334-346. doi: 10.1016/j.ejmech.2018.03.004. Epub 2018 Mar 6. Eur J Med Chem. 2018. PMID: 29544147 Free PMC article.

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Linking autoantigen properties to mechanisms of immunity.

Griffin JD, Song JY, Sestak JO, DeKosky BJ, Berkland CJ. Griffin JD, et al. Adv Drug Deliv Rev. 2020;165-166:105-116. doi: 10.1016/j.addr.2020.04.005. Epub 2020 Apr 20. Adv Drug Deliv Rev. 2020. PMID: 32325104 Review.

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Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease.

Rathnayake AD, Kim Y, Dampalla CS, Nguyen HN, Jesri AM, Kashipathy MM, Lushington GH, Battaile KP, Lovell S, Chang KO, Groutas WC. Rathnayake AD, et al. J Med Chem. 2020 Oct 22;63(20):11945-11963. doi: 10.1021/acs.jmedchem.0c01252. Epub 2020 Oct 2. J Med Chem. 2020. PMID: 32945669

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Exploring the conformations of nitric oxide synthase with fluorescence.

Arnett DC, Bailey SK, Johnson CK. Arnett DC, et al. Front Biosci (Landmark Ed). 2018 Jun 1;23:2133-2145. Front Biosci (Landmark Ed). 2018. PMID: 29772550 Free PMC article. Review.

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Design of Substrate Transmembrane Mimetics as Structural Probes for γ-Secretase.

Bhattarai S, Devkota S, Meneely KM, Xing M, Douglas JT, Wolfe MS. Bhattarai S, et al. J Am Chem Soc. 2020 Feb 19;142(7):3351-3355. doi: 10.1021/jacs.9b13405. Epub 2020 Feb 4. J Am Chem Soc. 2020. PMID: 31999444 Free PMC article.

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In vivo methylation of OLA1 revealed by activity-based target profiling of NTMT1.

Jia K, Huang G, Wu W, Shrestha R, Wu B, Xiong Y, Li P. Jia K, et al. Chem Sci. 2019 Aug 9;10(35):8094-8099. doi: 10.1039/c9sc02550b. eCollection 2019 Sep 21. Chem Sci. 2019. PMID: 31857877 Free PMC article.

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Structural insights into the function of steroidogenic cytochrome P450 17A1.

Yadav R, Petrunak EM, Estrada DF, Scott EE. Yadav R, et al. Mol Cell Endocrinol. 2017 Feb 5;441:68-75. doi: 10.1016/j.mce.2016.08.035. Epub 2016 Aug 24. Mol Cell Endocrinol. 2017. PMID: 27566228 Free PMC article. Review.

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